Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: A multifunctional nanocarrier system for cancer diagnosis and treatment

ACS Nano

Volumn 4, Issue 9, 2010, Pages 5398-5404

  Cho, Hoon Sung ^a   Dong, Zhongyun ^b   Pauletti, Giovanni M ^a   Zhang, Jiaming ^c   Xu, Hong ^d   Gu, Hongchen ^d   Wang, Lumin ^c   Ewing, Rodney C ^c   Huth, Christopher ^a   Wang, Feng ^a   Shi, Donglu ^a,e  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e TONGJI UNIVERSITY   (China)

Author keywords

drug storage; fluorescent imaging; magnetic nanosphere; quantum dot; targeting

Indexed keywords

DRUG STORAGE; FLUORESCENT IMAGING; MAGNETIC NANOSPHERES; QUANTUM DOT; TARGETING;

CELLS; DISEASES; FLUORESCENCE; MAGNETIC STORAGE; MONOPOLE ANTENNAS; NANOCOMPOSITES; NANOSPHERES; OPTICAL WAVEGUIDES; POLYSTYRENES; SEMICONDUCTOR QUANTUM DOTS; SUPERPARAMAGNETISM; TUMORS;

ENZYME INHIBITION;

DRUG CARRIER; FLUORESCENT DYE; LACTIC ACID; MAGNETITE NANOPARTICLE; PACLITAXEL; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; QUANTUM DOT;

ANIMAL; ARTICLE; CELL TRANSFORMATION; CHEMISTRY; HUMAN; MALE; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; MOUSE; NANOMEDICINE; PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DRUG CARRIERS; FLUORESCENT DYES; HUMANS; LACTIC ACID; MAGNETITE NANOPARTICLES; MALE; MICE; MOLECULAR IMAGING; NANOMEDICINE; PACLITAXEL; POLYGLYCOLIC ACID; PROSTATIC NEOPLASMS; QUANTUM DOTS;

EID: 77957313417     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn101000e     Document Type: Article

References (27)

1. Wood, K. C.; Azarin, S. M.; Arap, W.; Pasqualini, R.; Langer, R.; Hammond, P. T. Tumor-Targeted Gene Delivery Using Molecularly Engineered Hybrid Polymers Functionalized with a Tumor-Homing Peptide Bioconjugate Chem. 2008, 19, 403-405
2. Inoue, Y.; Izawa, K.; Yoshikawa, K.; Yamada, H.; Tojo, A.; Ohtomo, K. In Vivo Fluorescence Imaging of the Reticuloendothelial System Using Quantum Dots in Combination with Bioluminescent Tumour Monitoring Eur. J. Nucl. Med. Mol. Imaging 2007, 34, 2048-2056
3. Qian, X.; Peng, X.-H.; Ansari, D. O.; Yin-Goen, Q.; Chen, G. Z.; Shin, D. M.; Yang, L.; Young, A. N.; Wang, M. D.; Nie, S. In Vivo Tumor Targeting and Spectroscopic Detection with Surface-Enhanced Raman Nanoparticle Tags Nat. Biotechnol. 2008, 26, 83-90
4. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Long-Circulating and Target-Specific Nanoparticles: Theory to Practice Pharmacol. Rev. 2001, 53, 283-318
5. Shekunov, B. Y.; Chattopadhyay, P.; Tong, H. H. Y.; Chow, A. H. L. Particle Size Analysis in Pharmaceutics: Principles, Methods and Applications Pharm. Res. 2007, 24, 203-227
6. Weissleder, R. A Clearer Vision for In Vivo Imaging Nat. Biotechnol. 2001, 19, 316-317
7. Jordan, A.; Scholz, R.; Wust, P.; Fähling, H.; Roland, F. Magnetic Fluid Hyperthermia (MFH): Cancer Treatment with Ac Magnetic Field Induced Excitation of Biocompatible Superparamagnetic Nanoparticles J. Magn. Magn. Mater. 1999, 201, 413-419
8. Hergt, R.; Dutz, S.; Müller, R.; Zeisberger, M. Magnetic Particle Hyperthermia: Nanoparticle Magnetism and Materials Development for Cancer Therapy J. Phys.: Condens. Matter 2006, 18, S2919
9. Neuberger, T.; Schöpf, B.; Hofmann, H.; Hofmann, M.; von Rechenberg, B. Superparamagnetic Nanoparticles for Biomedical Applications: Possibilities and Limitations of a New Drug Delivery System J. Magn. Magn. Mater. 2005, 293, 483-496
10. 4 Composite Nanospheres for In Vivo Imaging and Hyperthermia Adv. Mater. 2009, 21, 2170-2173
11. 4/Polystyrene/Silica Nanospheres via Combined Miniemulsion/Emulsion Polymerization J. Am. Chem. Soc. 2006, 128, 15582-15583
12. Franchini, M. C.; Baldi, G.; Bonacchi, D.; Gentili, D.; Giudetti, G.; Lasciafari, A.; Corti, M.; Marmorato, P.; Ponti, J.; Micotti, E. et al. Bovine Serum Albumin-Based Magnetic Nanocarrier for MRI Diagnosis and Hyperthermic Therapy: A Potential Theranostic Approach against Cancer Small 2010, 6, 366-370
13. Pan, D.; Caruthers, S. D.; Hu, G.; Senpan, A.; Scott, M. J.; Gaffney, P. J.; Wickline, S. A.; Lanza, G. M. Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular Targets J. Am. Chem. Soc. 2008, 130, 9186-9187
14. Liang, H.-F.; Chen, C.-T.; Chen, S.-C.; Kulkarni, A. R.; Chiu, Y.-L.; Chen, M.-C.; Sung, H.-W. Paclitaxel-Loaded Poly(l -Glutamic Acid)-Poly(Lactide) Nanoparticles as a Targeted Drug Delivery System for the Treatment of Liver Cancer Biomaterials 2006, 27, 2051-2059
15. Lu, Z.; Yeh, T.-K.; Tsai, M.; Au, J. L. S.; Wientjes, M. G. Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy Clin. Cancer Res. 2004, 10, 7677-7684
16. Sahoo, S. K.; Ma, W.; Labhasetwar, V. Efficacy of Transferrin-Conjugated Paclitaxel-Loaded Nanoparticles in a Murine Model of Prostate Cancer Int. J. Cancer 2004, 112, 335-340
17. Koziara, J. M.; Lockman, P. R.; Allen, D. D.; Mumper, R. J. Paclitaxel Nanoparticles for the Potential Treatment of Brain Tumors J. Controlled Release 2004, 99, 259-269
18. Dunne, M.; Corrigan, O. I.; Ramtoola, Z. Influence of Particle Size and Dissolution Conditions on the Degradation Properties of Polylactide- co -Glycolide Particles Biomaterials 2000, 21, 1659-1668
19. Grayson, A. C. R.; Cima, M. J.; Langer, R. Size and Temperature Effects on Poly(lactic- co -glycolic acid) Degradation and Microreservoir Device Performance Biomaterials 2005, 26, 2137-2145
20. Reed, A. M.; Gilding, D. K. Biodegradable Polymers for Use in Surgery-Poly(glycolic)/Poly(lactic acid) Homo and Copolymers: 2. In Vitro Degradation Polymer 1981, 22, 494-498
21. Dong, Y.; Feng, S.-S. Poly(d, l -lactide- co -glycolide)/Montmorillonite Nanoparticles for Oral Delivery of Anticancer Drugs Biomaterials 2005, 26, 6068-6076
22. Ong, B. Y. S.; Ranganath, S. H.; Lee, L. Y.; Lu, F.; Lee, H.-S.; Sahinidis, N. V.; Wang, C.-H. Paclitaxel Delivery from PLGA Foams for Controlled Release in Post-Surgical Chemotherapy against Glioblastoma Multiforme Biomaterials 2009, 30, 3189-3196
23. Fonseca, C.; Simõs, S.; Gaspar, R. Paclitaxel-Loaded PLGA Nanoparticles: Preparation, Physicochemical Characterization and In Vitro Anti-tumoral Activity J. Controlled Release 2002, 83, 273-286
24. Jin, C.; Bai, L.; Wu, H.; Song, W.; Guo, G.; Dou, K. Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells Pharm. Res. 2009, 26, 1776-1784
25. Guo, Y.; Shi, D.; Cho, H.; Dong, Z.; Kulkami, A.; Pauletti, G. M.; Wang, W.; Lian, J.; Liu, W.; Ren, L. et al. In Vivo Imaging and Drug Storage by Quantum-Dot-Conjugated Carbon Nanotubes Adv. Funct. Mater. 2008, 18, 2489-2497
26. Mu, L.; Seow, P. H. Application of TPGS in Polymeric Nanoparticulate Drug Delivery System Colloids Surf., B 2006, 47, 90-97
27. Desai, N.; Trieu, V.; Yao, Z.; Louie, L.; Ci, S.; Yang, A.; Tao, C.; De, T.; Beals, B.; Dykes, D. et al. Increased Antitumor Activity, Intratumor Paclitaxel Concentrations, and Endothelial Cell Transport of Cremophor-Free, Albumin-Bound Paclitaxel, Abi-007, Compared with Cremophor-Based Paclitaxel Clin. Cancer Res. 2006, 12, 1317-1324