LC-MS/MS method development and validation for the determination of polymyxins and vancomycin in rat plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 28, 2010, Pages 2831-2838

  Cheng, Chang ^a   Liu, Shaorong ^a   Xiao, Deqing ^b   Hollembaek, John ^b   Yao, Lili ^b   Lin, Jing ^b   Hansel, Steven ^b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b PFIZER INC   (United States)

Author keywords

Antibacterial; Colistin; LC MS MS; Peptide drugs; Polymyxin; Sample recovery; Trichloroacetic acid; Vancomycin

Indexed keywords

ANTIBACTERIAL; COLISTIN; LC-MS/MS; PEPTIDE DRUGS; POLYMYXIN; SAMPLE RECOVERY; TRICHLOROACETIC ACID; VANCOMYCIN;

ACIDS; CONCENTRATION (PROCESS); ION SOURCES; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES; PLASMA (HUMAN); PLASMAS;

RECOVERY;

COLISTIN A; POLYMYXIN B1; POLYMYXIN B2; POLYMYXIN DERIVATIVE; POLYMYXIN E2; TRICHLOROACETIC ACID; UNCLASSIFIED DRUG; VANCOMYCIN;

ACCURACY; ARTICLE; CALIBRATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, LIQUID; LINEAR MODELS; POLYMYXINS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TRICHLOROACETIC ACID; VANCOMYCIN;

RATTUS;

EID: 77957295510     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.08.037     Document Type: Article

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