Biomarkers in neuroendocrine tumors

Frontiers in Bioscience - Scholar

Volumn 2 S, Issue 1, 2010, Pages 332-342

  Berretta, Massimiliano ^a   Cappellani, Alessandro ^b   Di Vita, Maria ^b   Berretta, Salvatore ^b   Nasti, Guglielmo ^c   Bearz, Alessandra ^d   Tirelli, Umberto ^a   Canzonieri, Vincenzo ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d National Cancer Institute Aviano ^*

Author keywords

Cancer; Clinical Biomarkers; Diagnosis; Neuroendocrine tumors; Review

Indexed keywords

ENZYME; NERVE PROTEIN; PEPTIDE HORMONE; TUMOR MARKER;

BLOOD; HUMAN; METABOLISM; NEUROENDOCRINE TUMOR; REVIEW;

ENZYMES; HUMANS; NERVE TISSUE PROTEINS; NEUROENDOCRINE TUMORS; PEPTIDE HORMONES; TUMOR MARKERS, BIOLOGICAL;

EID: 77957293966     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s68     Document Type: Article

References (63)

1. Ronald A DeLellis. The neuroendocrine system and its tumors: an overview. Am J Clin Pathol 115, S5 (2001)
2. Antony G Pearse. The cytochemistry and ultrastructure of polypeptide-hormone producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17, 303-313 (1969)
3. Carlo Capella, Philip U Heitz, Heinz Höfler, Enrico Solcia, Gunter Klöppel. Revised classification of neuroendocrine tumors of the lung, pancreas and gut. Virchows Arch 425, 547-560 (1995)
4. Eric Baudin, Jean-Michel Bidart, Philippe Rougier, Vladimir Lazar, Pierre Ruffié, Jacques Ropers, Michel Ducreux, Frédéric Troalen, Jean-Christophe Sabourin, Etienne Comoy, Philippe Lasser, Thierry DeBaere, Martin Schlumberger. screening for multiple endocrine neoplasia type 1 and hormonal production in apparently sporadic neuroendocrine tumors. J Clin Endocrinol Metab 84, 69-75 (1999) (Pubitemid 29036682)
5. Wouter W de Herder. Biochemistry of neuroendocrine tumors. Best Pract Res Clin Endocrinol Metab 21, 33-41 (2007)
6. Daniel T O'Connor, Ronald P Frigon. Chromogranin A, the major catecholamine storage vesicle solution protein. Multiple size forms, subcellular storage and regional distribution in chromaffin and nervous tissue elucidated by radioimmunoassay. J Biol Chem 259, 3237-3247 (1984) (Pubitemid 14159450)
7. Barry S Wilson, Ricardo V Lloyd. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol 115, 458-468 (1984). (Pubitemid 14121197)
8. Ricardo V Lloyd. Practical markers used in the diagnosis of neuroendocrine tumors. Endocrine Pathology 14, 293-301 (2003) (Pubitemid 38903383)
9. Shimon Schuldiner, Anat Shirvan, Michal Linial. Vesicular neurotransmitter transporters: from bacteria to humans. Physiol Rev 75, 369-392 (1995)
10. Jeffrey D Erickson, Martin K-H Schafer, Tom I Bonner, Lee E Eiden, Eberhard Weihe. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc Natl Acad Sci 93, 5166-5171 (1996) (Pubitemid 26162890)
11. Rolf Eisselea, Martin Anlaufb, Martin K.-H. Schäferb, Lee E. Eidenc, Rudolf Arnolda, Eberhard Weiheb. Expression of vesicular monoamine transporters in endocrine hyperplasia and endocrine tumors of the oxyntic stomach. Digestion 60, 428-439 (1999)
12. Lucio Scopsi, Maria Gullo, Franco Rilke, Sean Martin, David F Steiner. Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation. J Clin Endocrinol Metab 80, 294-301 (1995)
13. Marco Volante, Francesca Bozzalla-Cassione, Mauro Papotti. Somatostatin receptors and their interest in diagnostic pathology. Endocrine Pathology 15, 275-292 (2004)
14. Hasan Kulaksiz, Rolf Eissele, Dirk Rössler, Stefan Schulz, Volker Höllt, Yalcin Cetin, Rudolf Arnold. Identification of somatostatin receptor subtypes 1, 2A, 3 and 5 in neuroendocrine tumors with subtype specific antibodies. Gut 50, 52-60 (2002) (Pubitemid 34028303)
15. Thomas O'Dorisio, Aaron Vinik. Pancreatic polypeptide and mixed peptide-producing tumors of the gastrointestinal tract. In Contemporary Issues in Gastroenterology. Eds: Cohen S, Soloway RD. Churchill-Livingstone, NY (1985)
16. Gareth T Williams. Endocrine tumors of the gastrointestinal tract-selected topics. Histopathology 50, 30-41 (2007) (Pubitemid 44953396)
17. Anja M Schmitt, Martin Anlauf, Valentin Rousson, Sonja Schmid, Andreas Kofler, Florian Riniker, Juliane Bauersfeld, Andre Barghorn, Nicole M Probst-Hensch, Holger Moch, Philipp U Heitz, Guenter Kloeppel, Paul Komminoth, Aurel Perren. WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors. Am J Surg Pathol 31, 1677-1682 (2007) (Pubitemid 350287565)
18. Amitabh Srivastava, Osvaldo Padilla, Reiner Fischer-Colbrie, Arthur S Tischler, Yogeshwar Dayal. Neuroendocrine secretory protein-55 (NESP-55) expression discriminates pancreatic endocrine tumors and pheochromocytomas from gastrointestinal and pulmonary carcinoids. Am J Surg Pathol 28, 1371-1378 (2004) (Pubitemid 39336377)
19. Lori A Erickson, Bettina Papouchado, Haitham Dimashkieh, Shiwu Zhang, Naotoshi Nakamura, Ricardo V Lloyd. Cdx2 as a marker for neuroendocrine tumors of unknown primary sites. Endocrine Pathology 15, 247-252 (2004) (Pubitemid 40169418)
20. Stefano La Rosa, Elena Rigoli, Silvia Uccella, Anna Maria Chiaravalli, Carlo Capella. CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. Virchows Archiv 445, 248-254 (2004) (Pubitemid 39286892)
21. Yun-Cai Cai, Barbara Banner, Jonathan Glickman, Robert D Odze. Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. Human Pathology 32, 1087-1093 (2001) (Pubitemid 33015669)
22. Anna M O'Kane, Mark E O'Donnell, Rajeev Shah, Declan P Carey, Jack Lee. Small cell carcinoma of the appendix. World J Surg Oncol 6, 1-4 (2008)
23. Anjali Saqi, Diane Alexis, Fabrizio Remotti, Govind Bhagat. Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids. Am J Clin Pathol 123, 394-404 (2005) (Pubitemid 40315081)
24. Akihide Tanimoto, Yasumasa Matsuki, Tatsuo Tomita, Takakazu Sasaguri, Shohei Shimajiri, Yasuyuki Sasaguri. Histidine decarboxylase expression in pancreatic endocrine cells and related tumors. Pathol Int 54, 408-412 (2004) (Pubitemid 38829926)
25. Gerhard E. Feurle, Martin Anlauf, Gerd Hamscher, Rudolf Arnold, Günter Klöppel, Eberhard Weihe. Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of the duodenal origin. Gastroenterology 123, 1616-1626 (2002) (Pubitemid 35231661)
26. Malcolm R Alison. Assessing cellular proliferation: what's worth measuring? Hum Exp Toxicol 14, 935-944 (1995) (Pubitemid 26008615)
27. Stefano La Rosa, Fausto Sessa, Filippo Bosi, Andrea Fabbri, Carlo Capella. Prognostic factors in nonfunctioning pancreatic endocrine tumors. Lab Invest 72, 54A (1995)
28. Gildas Rigaud, Edoardo Missiaglia, Patrick S. Moore, Giuseppe Zamboni, Massimo Falconi, Giorgio Talamini, Anna Pesci, Antonella Baron, Daniele Lissandrini, Guido Rindi, Piergiovanni Grigolato, Paolo Pederzoli, Aldo Scarpa. High resolution allelotype of nonfunctional pancreatic endocrine tumors: identification of two molecular subgroups with clinical implications. Cancer Res 61, 285-292 (2001) (Pubitemid 32095729)
29. Giuliano Pelosi, Giuseppe Zamboni, Claudio Doglioni, Stefania Rodella, Enrica Bresaola, Calogero Iacono, Giovanni Serio, Antonio Iannucci, Aldo Scarpa. Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predict malignancy in endocrine tumors of the pancreas. Am J Surg Pathol 16, 1215-1225 (1992) (Pubitemid 23004427)
30. Ayumu Goto, Tomoya Niki, Yuichi Terado, Junko Fukushima, Masashi Fukayama. Prevalence of CD99 protein expression in pancreatic endocrine tumors (PETs). Histopathology 45, 384-392 (2004) (Pubitemid 39430643)
31. Mina Jamali, Runjan Chetty. Predicting prognosis in gastroentero- pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining. Endocr Pathol 19, 282-288 (2008)
32. Daniel T O'Connor, Leonard J Deftos. Secretion of chromogranin A by peptide-producing endocrine neoplasms. N Engl J Med 314, 1145-1151 (1986) (Pubitemid 16138661)
33. Leonard J Deftos. Chromogranin A: Its role in endocrine function and as an endocrine and neuroendocrine tumor marker. Endocr Rev 12, 181-187 (1991)
34. Gregor Schürmann, Ulrich Raeth, Bertram Wiedenmann, Heinrich Buhr, Christian Herfarth. Serum Chromogranin A in the diagnosis and follow-up of neuroendocrine tumors of the gastroenteropancreatic tract. World J Surg 16, 697-701 (1992)
35. Laurence Guignat, Jean Michel Bidart, Maryalice Nocera, Emmanuel Comoy, Martin Schlumberger, Elisabeth Baudin. Chromogranin A and the alpha-subunit of glycoprotein hormones in medullary thyroid carcinoma and pheochromocytoma. Br J Cancer 84, 808-812 (2001) (Pubitemid 32275655)
36. Anna L Iacangelo, Lee E Eiden. Chromogranin A: a current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway. Regul Pept 49, 497-528 (1995)
37. Paola Tomassetti, Marina Migliori, Patrizia Simoni, Riccardo Casadei, Rossella De Iasio, Roberto Corinaldesi, Lucio Gullo. Diagnostic value of plasma chromogranin A in neuroendocrine tumors. Eur J Gastroenterol Hepatol 13, 55-58 (2001) (Pubitemid 32099569)
38. Kjell Oberg, Eva T Janson, Barbro Eriksson. Tumor markers in neuroendocrine tumors. Ital J Gastroenterol Hepatol 31, S160-S162 (1999)
39. Eric Baudin, Jean Michel Bidart, Anne Bachelot, Michel Ducreux, Daniel Elias, Pierre Ruffié, Martin Schlumberger. Impact of chromogranin A measurement in the work-up of neuroendocrine tumors. Ann Oncol 12, s79-82 (2001)
40. Piero Ferolla, Giuliano Faggiano, Gelsomina Mansueto, Nicola Avenia, Maria G Cantelmi, Paolo Giovenali, Maria Laura Del Basso De Caro, Francesco Milone, Giorgio Scarpelli, Stefania Masone, Fausto Santeusanio, Gabriela Lombardi, Gloria Angeletti, Annamaria Colao. The biological characterization of neuroendocrine tumors: The role of neuroendocrine markers. J Endocrinol Invest 31, 277-286 (2008) (Pubitemid 351638409)
41. Daniel T O'Connor, Leonard J Deftos. Secretion of chromogranin A by peptide-producing endocrine neoplasms. N Engl J Med 314, 1145-1151 (1986) (Pubitemid 16138661)
42. Frank R. E. Nobels, Dik J. Kwekkeboom, Willy Coopmans, Christiaan H. H. Schoenmakers, Jan Lindemans, Wouter W. De Herder, Eric P. Krenning, Roger Bouillon, Steven W. J. Lamberts. Chromogranin A as serum for neuroendocrine neoplasia: comparison with neuron-specific enolase and the α-subunit of glycoprotein hormones. J Clin Endocrinol Metab 82, 2622-2628 (1997) (Pubitemid 27337883)
43. Frank R. E. Nobels, Dik J. Kwekkeboom, Willy Coopmans, Ronnie Hoekstra, Roger Bouillon, Steven W. J. Lamberts. A comparison between the diagnostic value of the measurement of gonadotropins α-subunit and chromogranin A and their response to TRH in clinically non-functioning, alpha-subunit secreting and gonatroph pituitary adenomas. J Clin Endocrinol Metab 183, 200-213 (1993)
44. Eva T Janson, Lars Holmberg, Mats Stridsberg, Barbro Eriksson, Elvar Theodorsson, Erik Wilander, Kjell Oberg. Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol 8, 685-690 (1997) (Pubitemid 27372168)
45. Dan Granberg, Mats Stridsberg, Rein Seensalu, Barbro Eriksson, Gudmar Lundqvist, Kjell Öberg and Britt Skogseid. Plasma chromogranin A in patients with multiple endocrine neoplasia type 1 J Clin Endocrinol Metab 84, 2712-2717 (1999) (Pubitemid 30641998)
46. Joy ES Ardill. Circulating markers for neuroendocrine tumors of the gastroenteropancreatic tract. Ann Clin Biochem 45, 539-559 (2008)
47. Tapan Shah, Rajaventhan Srirajaskanthan, Meetu Bhogal, Christos Toubanakis, Timothy Meyer, Amanda Noonan, Caroline Witney-Smith, Tarek Amin, Pamela Bhogal, Nat Sivathasan, Brian Warner, Daniel Hochhauser, Martyn E Caplin. Alpha-Fetoprotein and human chorionic gonadotrophin-b as prognostic markers in neuroendorine tumor patients. Br J Canc 99, 72-77 (2008) (Pubitemid 351920226)
48. Barbro Eriksson, Kjell Oberg, Mats Stridsberg, Tumor markers in neuroendocrine tumors. Digestion 62, 33-38 (2000) (Pubitemid 30665937)
49. Francesco Panzuto, Carola Severi, Renato Cannizzaro, Massimo Falconi, Silvia Angeletti, Alessandra Pasquali, Vito D Corleto, Bruno Annibale, Angela Buonadonna, Paolo Pederzoli, Gianfranco Delle Fave. Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors. Journal of Endocrinol Invest 27, 6-11 (2004) (Pubitemid 38324712)
50. Marion M O'Hare, John G Daly, Kyle D Buchanan. Radioimmunoassay for pancreatic polypeptide, and its age-related changes concentration. Clin Chem 29, 1923-1927 (1983) (Pubitemid 13023979)
51. Elizabeth A Fialkowski, Jeffrey F. Moley. Current approaches in medullary thyroid carcinoma, sporadic and familial. J Surg Oncol 2006, 9:737-47. (Pubitemid 44902074)
52. Hitoshi Ito, Jun Hata, Hiroshi Yokozaki, Eiichi Tahara. Calcitonin in human gastric mucosa and carcinoma. J Cancer Res Clin Oncol 112, 50-56 (1986) (Pubitemid 16058541)
53. Alexander L. Agranovich, George H. Anderson, Mohamed Manji, Brian D. Acker, Walter C. Macdonald, William J. Threlfall, Carcinoid tumor of the gastrointestinal tract: Prognostic facto and disease out come. J Surg Oncol 47, 45-52 (1991)
54. Eva T Janson, Lars Holmberg, Mats Stridsberg, Barbro Eriksson, Elvar Theodorsson, Eric Wilander, Kiell Oberg Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol 8, 685-690 (1997) (Pubitemid 27372168)
55. Gunnel Westberg, Bo Wängberg, Hakan Ahlman, Claes-Hakan Bergh, Marie Beckman-Suurküla, Kenneth Caidahl. Prediction of prognosis by echocardiography in patients with midgut carcinoid syndrome. Br J Surg 88, 865-872 (2001) (Pubitemid 32823842)
56. Tim J Degg, Keith R Allen, Julian H Barth. Measurement of plasma 5 hydroxyindoleacetic acid in carcinoid disease as an alternative to 24 h urine collection? Ann Clin Biochem 37, 724-726 (2000)
57. Joy ES Ardill, Bo Erikkson. The importance of the measurement of circulating markers in patients with neuroendocrine tumors of the pancreas and gut. Endocr Relat Canc 10, 459-462 (2003) (Pubitemid 38094882)
58. Irvin M Modlin, Mark Kidd, Igor Latich, Michelle N Zikusoka, Michael D Shapiro. Current status of gastrointestinal carcinoids. Gastroenterology 128, 1717-1751 (2005) (Pubitemid 40692562)
59. Barbro Eriksson, Kjell Oberg. Peptide hormones as tumor markers in neuroendocrine gastrointestinal tumors. Acta Oncol 30, 477-483 (1991)
60. Sabrina Corbetta, Maddalena Peracchi, Valentina Cappiello, Andrea Lania, Eleonora Lauri, Luca Vago, Paolo Beck-Peccoz, Anna Spada. Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab 88, 3117-3120 (2003) (Pubitemid 36877481)
61. Apostolos V Tsolakis, Guida M Portela-Gomes, Mats Stridsberg, Lars Grimelius, Anders Sundin, Barbro K Eriksson, Kjell E Öberg, Eva T Janson. Malignant gastric ghrelinoma with hyperghrelinemia. J Clin Endocrinol Metab 89, 3739-3744 (2004) (Pubitemid 39071466)
62. Ulrich-Frank Pape, Henning Jann, Jacqueline Müller-Nordhorn, Angelina Bockelbrink, Uta Berndt, Stefan N Willich, Martin Koch, Christoph Röcken, Guido Rindi, Bertram Wiedenmann Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Cancer 113, 256-265 (2008)
63. Eva-Maria Duerr, Yusuke Mizukami, Aylwin Ng, Ramnik J Xavier, Hirotoshi Kikuchi, Vikram Deshpande, Andrew L Warshaw, Jonathan Glickman, Matthew H Kulke, Daniel C Chung. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis Endocrine-Related Cancer 15, 243-256, (2008) (Pubitemid 351449743)