Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis

Endocrine-Related Cancer

Volumn 15, Issue 1, 2008, Pages 243-256

  Duerr, Eva Maria ^a   Mizukami, Yusuke ^a,d   Ng, Aylwin ^a   Xavier, Ramnik J ^a   Kikuchi, Hirotoshi ^a   Deshpande, Vikram ^a   Warshaw, Andrew L ^a   Glickman, Jonathan ^b   Kulke, Matthew H ^c   Chung, Daniel C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CELL NUCLEUS RECEPTOR; EXTRACELLULAR MATRIX PROTEIN 1; GALECTIN 4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SCLEROPROTEIN; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 1;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CARCINOMA; CONTROLLED STUDY; DNA MICROARRAY; ENDOCRINE TUMOR; FEMALE; GASTROINTESTINAL TUMOR; GENE CLUSTER; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; MICROARRAY ANALYSIS; MUTATIONAL ANALYSIS; NEUROENDOCRINE TUMOR; ONCOGENE RET; PANCREAS TUMOR; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR DIFFERENTIATION; TUMOR GROWTH; UPREGULATION; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CELL DIFFERENTIATION; FEMALE; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION PROFILING; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEUROENDOCRINE TUMORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TUMOR MARKERS, BIOLOGICAL;

EID: 41349101747     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/ERC-07-0194     Document Type: Article

References (46)

1. Arighi E, Borrello MG & Sariola H 2005 RET tyrosine kinase signaling in development and cancer. Cytokine and Growth Factor Reviews 16 441-467.
2. Bloomston M, Durkin A, Yang I, Rojiani M, Rosemurgy AS, Enkmann S, Yeatman TJ & Zervos EE 2004 Identification of molecular markers specific for pancreatic neuroendocrine tumors by genetic profiling of core biopsies. Annals of Surgical Oncology 11 413-419.
3. Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Campanini N, Swift SM, Bordi C, Fave GD et al. 2006 Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets. Endocrine-Related Cancer 13 541-558.
4. Chung DC, Brown SB, Graeme-Cook F, Seto M, Warshaw AL, Jensen RT & Arnold A 2000 Overexpression of cyclin D1 occurs frequently in human pancreatic endocrine tumors. Journal of Clinical Endocrinology and Metabolism 85 4373-4378.
5. Couvelard A, Hu J, Steers G, O'Toole D, Sauvanet A, Belghiti J, Bedossa P, Gatter K, Ruszniewski P & Pezzella F 2006 Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors. Gastroenterology 131 1597-1610.
6. Dilley WG, Kalyanaraman S, Verma S, Cobb JP, Laramie JM & Lairmore TC 2005 Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome. Molecular Cancer 4 9.
7. Draghici S, Khatri P, Bhavsar P, Shah A, Krawetz SA & Tainsky MA 2003 Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Nucleic Acids Research 31 3775-3781.
8. Duerr EM & Chung DC 2007 Molecular genetics of neuroendocrine tumors. Nucleic Acids Research 21 1-14.
9. Eisen MB, Spellman PT, Brown PO & Botstein D 1998 Cluster analysis and display of genome-wide expression patterns. PNAS 95 14863-14868.
10. Evers BM, Rady PL, Sandoval K, Arany I, Tyring SK, Sanchez RL, Nealon WH, Townsend CM Jr & Thompson JC 1994 Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. Annals of Surgery 219 596-601.
11. Fjallskog ML, Lejonklou MH, Oberg KE, Eriksson BK & Janson ET 2003 Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clinical Cancer Research 9 1469-1473.
12. Gansner ER & North SC 2000 An open graph visualization system and its applications to software engineering. Software - Practice and Experience 30 1203-1233.
13. Goebel SU, Iwamoto M, Raffeld M, Gibril F, Hou W, Serrano J & Jensen RT 2002 Her-2/neu expression and gene amplification in gastrinomas: correlations with tumor biology, growth, and aggressiveness. Cancer Research 62 3702-3710.
14. Guo SS, Wu X, Shimoide AT, Wong J & Sawicki MP 2001 Anomalous overexpression of p27(Kip1) in sporadic pancreatic endocrine tumors. Journal of Surgical Research 96 284-288.
15. Guo SS, Wu X, Shimoide AT, Wong J, Moatamed F & Sawicki MP 2003 Frequent overexpression of cyclin D1 in sporadic pancreatic endocrine tumours. Journal of Endocrinology 179 73-79.
16. Hansel DE, Rahman A, House M, Ashfaq R, Berg K, Yeo CJ & Maitra A 2004 Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Clinical Cancer Research 10 6152-6158.
17. Hobday TJ, Rubin J, Holen K, Picus J, Donehower R, Marschke R, Maples W, Lloyd R, Mahoney M & Erlichman C 2007 MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): a Phase II Consortium (P2C) study. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I 25 4504.
18. House MG, Herman JG, Guo MZ, Hooker CM, Schulick RD, Cameron JL, Hruban RH, Maitra A & Yeo CJ 2003a Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms. Surgery 134 902-908.
19. House MG, Herman JG, Guo MZ, Hooker CM, Schulick RD, Lillemoe KD, Cameron JL, Hruban RH, Maitra A & Yeo CJ 2003b Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. Annals of Surgery 238 423-431.
20. Huflejt ME & Leffler H 2004 Galectin-4 in normal tissues and cancer. Glycoconjugate Journal 20 247-255.
21. Kamada T & Kawai S 1989 An algorithm for drawing general undirected graphs. Information Processing Letters 31 7-15.
22. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH & McMillan A 2005 ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy. Annals of Surgery 242 353-361.
23. Kim DW, Jo YS, Jung HS, Chung HK, Song JH, Park KC, Park SH, Hwang JH, Rha SY, Kweon GR et al. 2006 An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. Journal of Clinical Endocrinology and Metabolism 91 4070-1076.
24. Kloppel G, Perren A & Heitz PU 2004 The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Annals of the New York Academy of Sciences 1014 13-27.
25. Kulke M, Lenz HJ, Meropol NJ, Posey J, Ryan DP, Picus J, Bergsland E, Stuart K, Baum CM & Fuchs CS 2005 A phase 2 study to evaluate the efficacy and safety of SU11248 in patients (pts) with unresectable neuroendocrine tumors (NETs). Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings 23 4008.
26. Kytola S, Hoog A, Nord B, Cedermark B, Frisk T, Larsson C & Kjellman M 2001 Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids. American Journal of Pathology 158 1803-1808.
27. Larsen CM, Dossing MG, Papa S, Franzoso G, Billestrup N & Mandrup-Poulsen T 2006 Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells. Diabetologia 49 980-989.
28. Lee S, Hong SW, Moon WC, Oh MR, Lee JK, Ahn CW, Cha BS, Kim KR, Lee HC & Lim SK 2005 High prevalence of c-RET expression in papillary thyroid carcinomas from the Korean population. Thyroid 15 259-266.
29. Li C & Hung Wong W 2001 Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biology 2 RESEARCH0032.
30. Maitra A, Hansel DE, Argani P, Ashfaq R, Rahman A, Naji A, Deng S, Geradts J, Hawthorne L, House MG et al. 2003 Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clinical Cancer Research 9 5988-5995.
31. Mongiat M, Fu J, Oldershaw R, Greenhalgh R, Gown AM & Iozzo RV 2003 Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. Journal of Biological Chemistry 278 17491-17499.
32. Muscarella P, Melvin WS, Fisher WE, Foor J, Ellison EC, Herman JG, Schirmer WJ, Hitchcock CL, DeYoung BR & Weghorst CM 1998 Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation. Cancer Research 58 237-240.
33. Nilsson O, Jakobsen AM, Kolby L, Bernhardt P, Forssell-Aronsson E & Ahlman H 2004 Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors. Annals of the New York Academy of Sciences 1014 280-283.
34. Peri S, Navarro JD, Kristiansen TZ, Amanchy R, Surendranath V, Muthusamy B, Gandhi TK, Chandrika KN, Deshpande N, Suresh S et al. 2004 Human protein reference database as a discovery resource for proteomics. Nucleic Acids Research 32 D497-D501.
35. Peter M, Couturier J, Pacquement H, Michon J, Thomas G, Magdelenat H & Delattre O 1997 A new member of the ETS family fused to EWS in Ewing tumors. Oncogene 14 1159-1164.
36. Pietras K, Sjoblom T, Rubin K, Heldin CH & Ostman A 2003 PDGF receptors as cancer drug targets. Cancer Cell 3 439-443.
37. Rumilla KM, Erickson LA, Erickson AK & Lloyd RV 2006 Galectin-4 expression in carcinoid tumors. Endocrine Pathology 17 243-249.
38. Shan L, Nakamura Y, Nakamura M, Yokoi T, Tsujimoto M, Arima R, Kameya T & Kakudo K 1998 Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors. Laboratory Investigation 78 471-475.
39. Speel EJ, Richter J, Moch H, Egenter C, Saremaslani P, Rutimann K, Zhao J, Barghorn A, Roth J, Heitz PU et al. 1999 Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization. American Journal of Pathology 155 1787-1794.
40. Speel EJ, Scheidweiler AF, Zhao J, Matter C, Saremaslani P, Roth J, Heitz PU & Komminoth P 2001 Genetic evidence for early divergence of small functioning and nonfunctioning endocrine pancreatic tumors: gain of 9Q34 is an early event in insulinomas. Cancer Research 61 5186-5192.
41. Stumpf E, Aalto Y, Hoog A, Kjellman M, Otonkoski T, Knuutila S & Andersson LC 2000 Chromosomal alterations in human pancreatic endocrine tumors. Genes, Chromosomes and Cancer 29 83-87.
42. Terris B, Meddeb M, Marchio A, Danglot G, Flejou JF, Belghiti J, Ruszniewski P & Bernheim A 1998 Comparative genomic hybridization analysis of sporadic neuroendocrine tumors of the digestive system. Genes, Chromosomes and Cancer 22 50-56.
43. Tonnies H, Toliat MR, Ramel C, Pape UF, Neitzel H, Berger W & Wiedenmann B 2001 Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation. Gut 48 536-541.
44. Vikman S, Essand M, Cunningham JL, de la Torre M, Oberg K, Totterman TH & Giandomenico V 2005 Gene expression in midgut carcinoid tumors: potential targets for immunotherapy. Acta Oncologica 44 32-40.
45. Wang EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E Jr & Sawicki MP 1998 Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Research 58 4417-4420.
46. Wang GG, Yao JC, Worah S, White JA, Luna R, Wu TT, Hamilton SR & Rashid A 2005 Comparison of genetic alterations in neuroendocrine tumors: frequent loss of chromosome 18 in ileal carcinoid tumors. Modern Pathology 18 1079-1087.