Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart

Clinical and Translational Science

Volumn 3, Issue 3, 2010, Pages 81-89

  Zincarelli, Carmela ^a   Soltys, Stephen ^a,b   Rengo, Giuseppe ^a,b,c   Koch, Walter J ^a,b   Rabinowitz, Joseph E ^a  

^a Center for Translational Medicine   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c IRCCS   (Italy)

Author keywords

AAV cardiac tropism; Adeno associated virus; Gene therapy; Indirect intracoronary gene delivery

Indexed keywords

LUCIFERASE; LYMPHOCYTE ANTIGEN; PARVOVIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CLAMPING; ARTICLE; ASCENDING AORTA; CONTROLLED STUDY; CYTOMEGALOVIRUS; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; GENE TARGETING; GENE TRANSFER; HEART FUNCTION; HEART LEFT VENTRICLE; HEART MUSCLE; IMAGING SYSTEM; IMMUNOGENICITY; MACROPHAGE; MALE; MARKER GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SEROTYPE; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; ANIMAL; CLASSIFICATION; COMPARATIVE STUDY; CYTOLOGY; ELECTROCARDIOGRAPHY; GENE DOSAGE; GENETIC TRANSDUCTION; GENETICS; HEART FUNCTION TEST; IMMUNOLOGY; KINETICS; METABOLISM; METHODOLOGY; SEROTYPING; THREE DIMENSIONAL IMAGING; TISSUE DISTRIBUTION; TRANSGENE; VIRUS GENOME;

ADENO-ASSOCIATED VIRUS; ANIMALIA; CYTOMEGALOVIRUS; MUS;

ANIMALS; DEPENDOVIRUS; ELECTROCARDIOGRAPHY; GENE DOSAGE; GENOME, VIRAL; HEART FUNCTION TESTS; IMAGING, THREE-DIMENSIONAL; KINETICS; LUCIFERASES; MICE; MYOCARDIUM; SEROTYPING; TISSUE DISTRIBUTION; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 77957280335     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/j.1752-8062.2010.00190.x     Document Type: Article

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