Liposome-mediated gene transfection of endothelial nitric oxide synthase reduces endothelial activation and leukocyte infiltration in transplanted hearts

Circulation

Volumn 103, Issue 22, 2001, Pages 2753-2759

  Iwata, Akiko ^a   Sai, Sadahiro ^d   Nitta, Yoshio ^d   Chen, Megan ^e   De Fries Hallstrand, Ricarda ^b   Dalesandro, Joy ^f   Thomas, Robert ^a   Allen, Margaret D ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c HOPE HEART INSTITUTE   (United States)

^d TOHOKU UNIVERSITY   (Japan)

^e WELLESLEY COLLEGE   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cell adhesion molecules; Gene therapy; Ischemia; Nitric oxide; Reperfusion; Transplantation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM; GENE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; HEART TRANSPLANTATION; IMMUNOCYTOCHEMISTRY; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0035810917     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.22.2753     Document Type: Article

References (27)

1. The role of neutrophils in myocardial ischemia-reperfusion injury
2. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B
3. NO inhibits cytokine-induced iNOS expression and NF-kappa B activation by interfering with phosphorylation and degradation of I kappa B-alpha
4. Gene therapy for donor hearts: Ex vivo liposome-mediated transfection
5. Antibody to CD18 reduces neutrophil and T lymphocyte infiltration and vascular cell adhesion molecule-1 expression in cardiac rejection
6. Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium
7. Gene therapy of transplant arteriopathy by liposome-mediated transfection of endothelial nitric oxide synthase
8. In vivo studies of gene expression via transient transgenesis using lipid-DNA delivery
9. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice
10. Reduction in cellular and vascular rejection by blocking leukocyte adhesion molecule receptors
11. In vivo gene transfection of human endothelial cell nitric oxide synthase in cardiomyocytes causes apoptosis-like cell death: Identification using Sendai virus - Coated liposomes
12. Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase
13. Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds
14. Endothelial and myocardial cell protection by a cysteine-containing nitric oxide donor after myocardial ischemia and reperfusion
15. Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization
16. Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion
17. Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxide synthase gene
18. Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs
19. Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats
20. Role of endothelial nitric oxide synthase in endothelial cell migration
21. Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase
22. Nitric oxide synthase gene therapy rapidly reduces adhesion molecule expression and inflammatory cell infiltration in carotid arteries of cholesterol-fed rabbits
23. NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells
24. Cytokine-mediated apoptosis in cardiac myocytes: The role of inducible nitric oxide synthase induction and peroxynitrite generation
25. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid:cationic lipid complexes
26. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes
27. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA