Two weekly sessions of combined aerobic and resistance exercise are sufficient to provide beneficial effects in subjects with type 2 diabetes mellitus and metabolic syndrome

Journal of Endocrinological Investigation

Volumn 33, Issue 7, 2010, Pages 489-495

  Fatone, C ^a   Guescini, M ^b   Balducci, S ^c   Battistoni, S ^a   Settequattrini, A ^a   Pippi, R ^a   Stocchi, L ^b   Mantuano, M ^b   Stocchi, V ^b   De Feo, P ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Exercise; Metabolic syndrome; Mitochondrial function; Muscle gene expression; Obesity

Indexed keywords

ACETYLSALICYLIC ACID; AMLODIPINE; ATENOLOL; ATORVASTATIN; CARNITINE PALMITOYLTRANSFERASE I; CELL NUCLEUS DNA; CYTOCHROME C OXIDASE; ENALAPRIL; FORKHEAD TRANSCRIPTION FACTOR; FORKHEAD TRANSCRIPTION FACTOR BOX 01; GLICLAZIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; HEMOGLOBIN A1C; HYDROCHLOROTHIAZIDE; INSULIN RECEPTOR SUBSTRATE 1; IRBESARTAN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; METFORMIN; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RAMIPRIL; REPAGLINIDE; ROSIGLITAZONE; SIMVASTATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART INFARCTION; HUMAN; HYPERTENSION RETINOPATHY; ISCHEMIC HEART DISEASE; MALE; METABOLIC SYNDROME X; MICROALBUMINURIA; MUSCLE STRENGTH; NON INSULIN DEPENDENT DIABETES MELLITUS; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; RESISTANCE TRAINING; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; WAIST CIRCUMFERENCE;

ADULT; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; EXERCISE; FEMALE; GENE EXPRESSION; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MUSCLE, SKELETAL;

EID: 77957276526     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/6814     Document Type: Article

References (35)

1. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care 2006, 29: 1433-8.
2. Snowling NJ, Hopkins WG. Effect of different modes of exercise training on glucose control and risk factors for complication in type 2 diabetic patients. Diabetes Care 2006, 29: 2518-27.
3. Pedersen BK, Saltin B. Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 2006, 16 (Suppl. 1): 3-63. (Pubitemid 43433766)
4. De Feo P, Stocchi V. Physical activity for the treatment and prevention of metabolic syndrome. Nutr Metab Cardiovasc Dis 2007, 17: 327-31.
5. Haskell WL, Lee IM, Pate RR, et al. Physical Activity and Public Health: Updated recommendations for adults from the American College of Sports Medicine and the American Heart Association. Circulation 2007, 116: 1081-93.
6. Marwick TH, Hordern MD, Miller T, et al.; Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; Council on Nutrition, Physical Activity, and Metabolism; Interdisciplinary Council on Quality of Care and Outcomes Research. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009, 119: 3244-62.
7. Di Loreto C, Fanelli C, Lucidi P, et al. Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects. Diabetes Care 2003, 26: 404-8.
8. Di Loreto C, Fanelli C, Lucidi P, et al. Make your diabetic patients walk: long-term impact of different amounts of physical activity on type 2 diabetes. Diabetes Care 2005, 28: 1295-302.
9. Kirk A, De Feo P. Strategies to enhance compliance to physical activity for patients with insulin resistance. Appl Physiol Nutr Metab 2007, 32: 549-56.
10. Ibañez J, Izquierdo M, Argüelles I, et al. Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care 2005, 28: 662-7. (Pubitemid 40315329)
11. Honkola A, Forsén T, Eriksson J. Resistance training improves the metabolic profile in individuals with type 2 diabetes. Acta Diabetol 1997, 34: 245-8.
12. Brun JF, Bordenave S, Mercier J, Jaussent A, Picot MC, Préfaut C. Cost-sparing effect of twice-weekly targeted endurance training in type 2 diabetics: a one-year controlled randomized trial. Diabetes Metab 2008, 34: 258-65.
13. Sigal RJ, Kenny GP, Boulé NG, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007, 147: 357-69.
14. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 1988, 255: E769-74.
15. Balducci S, Zanuso S, Massarini M, et al. The Italian Diabetes and Exercise Study (IDES): Design and methods for a prospective Italian multicentre trial of intensive lifestyle intervention in people with type 2 diabetes and the metabolic syndrome. Nutr Metab Cardiovasc Dis 2008, 18: 585-95.
16. Balke B, Ware R. An experimental study of physical fitness of Air Force personnel. US Armed Forces Med J 1959; 10: 675-88.
17. Guescini M, Fatone C, Stocchi L, et al. Fine needle aspiration coupled with real-time PCR: A painless methodology to study adaptive functional changes in skeletal muscle. Nutr Metab Cardiovasc Dis 2007, 17: 383-93.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29: e45.
19. Maiden MA, Zar JH. Biostatistical Analysis (Second Edition). Englewood Cliffs: Prentice-Hall, 1984.
20. th ed. Baltimore: Lippincott Williams & Wilkins. 2000, 137-64.
21. Lee CH, Olson P, Evans RM. Lipid metabolism, metabolic disease, and peroxisome proliferators-activated receptors. Endocrinology 2003, 144: 2201-7. (Pubitemid 36629867)
22. Bragt MCE, Popeijus HE. Peroxisome proliferator-activated receptors and the metabolic syndrome. Physiol Behav 2008, 94: 187-97.
23. Toledo FGS, Menshikova EV, Ritov VB, et al. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in Type 2 diabetes. Diabetes 2007, 56: 2142-7.
24. Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 2004, 18: 357-68.
25. Hood DA, Irrcher I, Ljubicic V, Joseph AM. Coordination of metabolic plasticity in skeletal muscle. J Exp Biol 2006, 209: 2265-75.
26. Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005, 1: 361-70.
27. Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006, 116: 615-22.
28. Garnier A, Fortin D, Zoll J, et al. Coordinated changes in mitochondrial function and biogenesis in health and diseased human skeletal muscle. FASEB J 2005, 19: 43-52. (Pubitemid 40069919)
29. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc 2003, 35: 95-104. (Pubitemid 36084147)
30. Kim HJ, Lee JS, Kim CK. Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance. Eur J Appl Physiol 2004, 93: 353-8.
31. Kovacs P, Hanson RL, Lee YH, et al. The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians. Diabetes 2003, 52: 3005-9.
32. Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004, 117: 421-6.
33. Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOX01 -PGC-1alpha interaction. Nature 2003, 423: 550-5.
34. Pilegaard H, Saltin B, Neufer PD. Exercise induces transient transcriptional activation of the PGC-1alfa gene in human skeletal muscle. J Physiol 2003, 546: 851-8. (Pubitemid 36204518)
35. Kraniou GN, Cameron-Smith D, Hargreaves M. Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle. Exp Physiol 2004, 89: 559-63.