The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua

Reproductive Biology and Endocrinology

Volumn 8, Issue , 2010, Pages

  Basta, Pawel ^a,b   Majka, Marcin ^a   Jozwicki, Wojciech ^b   Lukaszewska, Ewelina ^b   Knafel, Anna ^a   Grabiec, Marek ^b   Stasienko, Elzbieta ^b   Wicherek, Lukasz ^a,b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; ECTOPIC PREGNANCY; ENDOMETRIOSIS; ENDOMETRIUM; ENDOMETRIUM TUMOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LAPAROSCOPY; MENSTRUAL CYCLE; REGULATORY T LYMPHOCYTE; UTERINE TUBE PREGNANCY; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CHORISTOMA; CYTOLOGY; DECIDUA; IMMUNOLOGY; METABOLISM; OVARY DISEASE; PATHOLOGY; PREGNANCY; UTERINE TUBE;

ADULT; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CHORISTOMA; DECIDUA; ENDOMETRIOSIS; ENDOMETRIUM; FALLOPIAN TUBES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; OVARIAN DISEASES; PREGNANCY; PREGNANCY, ECTOPIC; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 77957274635     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-8-116     Document Type: Article

References (42)

1. Starkey PM, Clover LM, Rees MC. Variation during the menstrual cycle of immune cell populations in human endometrium. Eur J Obstet Gynecol Reprod Biol 1991, 39:203-207. 10.1016/0028-2243(91)90058-S, 1709605.
2. King A, Burrows T, Loke YW. Human uterine natural killer cells. Nat Immun 1996, 15:41-52.
3. Gardner L, Moffett A. Dendritic cells in the human decidua. Biol Reprod 2003, 69:1438-1446. 10.1095/biolreprod.103.017574, 12826583.
4. Wilczynski JR, Kalinka J, Radwan M. The role of the T-regulatory cells in pregnancy and cancer. Front Biosci 2008, 13:2275-2289. 10.2741/2841, 17981709.
5. Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 2006, 203:871-881. 10.1084/jem.20050930, 2118300, 16606666.
6. Wicherek L, Gała{ogonek}zka K, Lazar A. The analysis of Metallothionein, RCAS1 immunoreactivity regarding immune cells concentration in endometrium and tubal mucosa in ectopic pregnancy during the course of tubal rupture. Gynecol Obstet Invest 2008, 65:52-61. 10.1159/000107649, 17717421.
7. Wicherek L, Popiela TJ, Galazka K, Dutsch-Wicherek M, Opławski M, Basta A, Klimek M. Metallothionein and RCAS1 expression in comparison to immunological cell activity in endometriosis, endometrial adenocarcinoma, and the endometrium according to menstrual cycle changes. Gynecol Oncol 2005, 99:622-630. 10.1016/j.ygyno.2005.07.003, 16112719.
8. Budiu RA, Diaconu I, Chrissluis R, Dricu A, Edwards RP, Vlad AM. A conditional mouse model for human MUC1-positive endometriosis shows the presence of anti-MUC1 antibodies and Foxp3+ regulatory T cells. Dis Model Mech 2009, 2:593-603. 10.1242/dmm.002535, 19841240.
9. Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004, 10:347-353. 10.1093/molehr/gah044, 14997000.
10. Kingsley CL, Karim M, Bushell AR, Wood KJ. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002, 168:1080-1086.
11. Hori S, Sakaguchi S. Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect 2004, 6:745-751. 10.1016/j.micinf.2004.02.020, 15207821.
12. Saito S, Sasaki Y, Sakai M. CD4(+)CD25high regulatory T cells in human pregnancy. J Reprod Immunol 2005, 65:111-120. 10.1016/j.jri.2005.01.004, 15811516.
13. Saito S, Shiozaki A, Sasaki Y, Nakashima A, Shima T, Ito M. Regulatory T cells and regulatory NK cells play an important roles in feto-maternal tolerance. Semin Immunopathol 2007, 29:115-122. 10.1007/s00281-007-0067-2, 17621697.
14. Tilburgs T, Roelen DL, van der Mast BJ, de Groot-Swings GM, Kleijburg C, Scherjon SA, Claas FH. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J Immunol 2008, 180:5737-5745.
15. Arruvito L, Sanz M, Banham AH, Fainboim L. Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J Immunol 2007, 178:2572-2578.
16. Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Malfertheiner SF, Costa SD, Zimmermann G, Nitschke C, Volk HD, Alexander H, Gunzer M, Zenclussen AC. Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol 2009, 182:5488-5497. 10.4049/jimmunol.0803177, 19380797.
17. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010, 63:601-610. 10.1111/j.1600-0897.2010.00852.x, 20455873.
18. Raghupathy R, Al-Mutawa E, Al-Azemi M, Makhseed M, Azizieh F, Szekeres-Bartho J. Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. J Reprod Immunol 2009, 80:91-99. 10.1016/j.jri.2009.01.004, 19371956.
19. Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010, 63:17-21. 10.1111/j.1600-0897.2009.00792.x, 20059465.
20. Dmowski WP, Ding J, Shen J, Rana N, Fernandez BB, Braun DP. Apoptosis in endometrial glandular cells in women with and without endometriosis. Hum Reprod 2001, 16:1802-1808. 10.1093/humrep/16.9.1802, 11527879.
21. Berbic M, Hey-Cunningham AJ, Ng C, Tokushige N, Ganewatta S, Markham R, Russell P, Fraser IS. The role of Foxp3+ regulatory T-cells in endometriosis: a potential controlling mechanism for a complex, chronic immunological condition. Hum Reprod 2010, 25:900-907. 10.1093/humrep/deq020, 20150173.
22. Polanczyk MJ, Hopke C, Vandenbark AA, Offner H. Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1). Int Immunol 2007, 19:337-343. 10.1093/intimm/dxl151, 17267414.
23. Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril 2001, 75:1-10. 10.1016/S0015-0282(00)01630-7, 11163805.
24. Wicherek L. Alterations in RCAS1 serum concentration levels during menstrual cycle in patients with uterine leiomyoma and lack of analogical changes in adenomyosis. Gynecol Obstet Invest 2009, 67:195-201. 10.1159/000188045, 19122463.
25. Wicherek L. Alterations in RCAS1 Serum Concentration Levels during the Normal Menstrual Cycle and the Lack of Analogical Changes in Ovarian Endometriosis. Am J Reprod Immunol 2008, 59:535-544. 10.1111/j.1600-0897.2008.00584.x, 18422812.
26. Basta P, Mach P, Pitynski K, Bednarek W, Klimek M, Zik{hooktop}tek J, Zaja{ogonek}c K, Wicherek L. Differences in the blood serum levels of soluble HLA-G concentrations between the menstrual cycle phases and menopause in patients with ovarian endometriosis and uterine leiomyoma. Neuro Endocrinol Lett 2009, 30:91-98.
27. Menier C, Prevot S, Carosella ED, Rouas-Freiss N. Human leukocyte antigen-G is expressed in advanced-stage ovarian carcinoma of high-grade histology. Hum Immunol 2009, 70:1006-1009. 10.1016/j.humimm.2009.07.021, 19660509.
28. Nakashima M, Sonoda K, Watanabe T. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. Nat Med 1999, 5:938-942. 10.1038/11383, 10426319.
29. Sonoda K, Miyamoto S, Hirakawa T, Yagi H, Yotsumoto F, Nakashima M, Watanabe T, Nakano H. Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer. Gynecol Oncol 2005, 97:772-779. 10.1016/j.ygyno.2005.02.025, 15943986.
30. Sonoda K, Miyamoto S, Nakashima M, Wake N. The biological role of the unique molecule RCAS1: a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis. Front Biosci 2008, 13:1106-1116. 10.2741/2748, 17981616.
31. Jasper MJ, Tremellen KP, Robertson SA. Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006, 12:301-308. 10.1093/molehr/gal032, 16574699.
32. Arruvito L, Sotelo AI, Billordo A, Fainboim L. A physiological role for inducible FOXP3(+) TREG cells Lessons from women with reproductive failure. Clin Immunol 2010, 136:432-441. 10.1016/j.clim.2010.05.002, 20542739.
33. Tilburgs T, Claas FH, Scherjon SA. Elsevier Trophoblast Research Award Lecture: Unique properties of decidual T cells and their role in immune regulation during human pregnancy. Placenta 2010, 31:82-86. 10.1016/j.placenta.2010.01.007, 20044137.
34. Sindram-Trujillo AP, Scherjon SA, van Hulst-van Miert PP, Kanhai HH, Roelen DL, Claas FH. Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy. J Reprod Immunol 2004, 62:125-137. 10.1016/j.jri.2003.11.007, 15288188.
35. Sindram-Trujillo AP, Scherjon SA, van Hulst-van Miert PP, van Schip JJ, Kanhai HH, Roelen DL, Claas FH. Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy. Hum Immunol 2003, 64:921-929. 10.1016/S0198-8859(03)00170-8, 14522088.
36. Sindram-Trujillo A, Scherjon S, Kanhai H, Roelen D, Claas F. Increased T-cell activation in decidua parietalis compared to decidua basalis in uncomplicated human term pregnancy. Am J Reprod Immunol 2003, 49:261-268. 10.1034/j.1600-0897.2003.00041.x, 12854730.
37. Galazka K, Wicherek L, Pitynski K, Kijowski J, Zajac K, Bednarek W, Dutsch-Wicherek M, Rytlewski K, Kalinka J, Basta A, Majka M. Changes in the subpopulation of CD25+ CD4+ and FOXP3+ regulatory T cells in decidua with respect to the progression of labor at term and the lack of analogical changes in the subpopulation of suppressive B7-H4 macrophages--a preliminary report. Am J Reprod Immunol 2009, 61:136-146. 10.1111/j.1600-0897.2008.00674.x, 19143677.
38. Wicherek L, Basta P, Sikora J, Galazka K, Rytlewski K, Grabiec M, Lazar A, Kalinka J. RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity. Am J Reprod Immunol 2007, 58:358-366. 10.1111/j.1600-0897.2007.00521.x, 17845206.
39. Wicherek L, Galazka K, Lazar A. RCAS1 Decidual Immunoreactivity during Placental Abruption: Immune Cell Presence and Activity. Am J Reprod Immunol 2007, 58:46-55. 10.1111/j.1600-0897.2007.00490.x, 17565547.
40. Wicherek L. The role of the endometrium in the regulation of immune cell activity. Front Biosci 2008, 13:1018-1035. 10.2741/2740, 17981608.
41. Wicherek L, Galazka K, Popiela TJ, Dutsch-Wicherek M, Czekierdowski A, Pabian W, Banas T, Migdal M, Klimek M. Metallothionein expression and infiltration of cytotoxic lymphocytes in uterine and tubal implantation sites. J Reprod Immunol 2006, 70:119-131. 10.1016/j.jri.2005.12.003, 16427139.
42. Wicherek L, Basta P, Pitynski K, Marianowski P, Kijowski J, Wiatr J, Majka M. The characterization of the subpopulation of suppressive B7H4(+) macrophages and the subpopulation of CD25(+) CD4(+) and FOXP3(+) regulatory T-cells in decidua during the secretory cycle phase, Arias Stella reaction, and spontaneous abortion-a preliminary report. Am J Reprod Immunol 2009, 61:303-312. 10.1111/j.1600-0897.2009.00696.x, 19260861.