The tensile strength of bilayered tablets made from different grades of microcrystalline cellulose

European Journal of Pharmaceutical Sciences

Volumn 41, Issue 3-4, 2010, Pages 483-488

  Podczeck, Fridrun ^a   Al Muti, Emad ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Flexural bending; Layered tablets; Microcrystalline cellulose; Tablet tensile strength; Uniaxial compression

Indexed keywords

MICROCRYSTALLINE CELLULOSE;

ARTICLE; MEASUREMENT; MOISTURE; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUALITY CONTROL; TABLET; TABLET COMPRESSION; TABLET POROSITY; TENSILE STRENGTH; YOUNG MODULUS;

CELLULOSE; PARTICLE SIZE; PRESSURE; TABLETS; TENSILE STRENGTH; WATER;

EID: 77957267781     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.08.002     Document Type: Article

References (24)

1. Abdul S., Poddar S.S. A flexible technology for modified release of drugs: multi layered tablets. J. Control. Release 2004, 97:393-405.
2. Belda P.M., Mielck J.B. Considerations about the theoretically expected crushing strength of tablets from binary powder mixtures: double layer tablets versus arithmetic additivity rule. Eur. J. Pharm. Biopharm. 2006, 64:343-350.
3. Benham P.P., Crawford R.J., Armstrong C.G. Mechanics of Engineering Materials 1999, Longmans, Harlow, UK, pp. 139-144. 2nd ed.
4. Bogan R.K. Treatment options for insomnia-pharmacodynamics of zolpidem extended-release to benefit next-day performance. Postgrad. Med. 2008, 120:161-171.
5. Cao H.C., Evans A.G. On crack extension in ductile/brittle laminates. Acta Metall. Mater. 1991, 39:2997-3005.
6. ® multi-layer matrix tablets containing drugs of different solubility. Biomaterials 1996, 17:889-896.
7. Conte U., Maggi L., Colombo P., LaManna A. Multi-layered hydrophilic matrices as constant release devices (Geomatrix™ Systems). J. Control. Release 1993, 26:39-47.
8. Dietrich P., Cremer K., Bauer-Brandl A., Schubert R. Adhesion strength in two-layer tablets. Pharm. Res. 1997, 14:S429.
9. Dietrich P., Cremer K., Bauer-Brandl A., Schubert R. Influence of particle size on adhesion in layered tablets. Proceedings of the Second World Meeting, APGI/APV 1998, 253-254.
10. Dietrich P., Bauer-Brandl A., Schubert R. Influence of tabletting forces and lubricant concentrations on the adhesion strength in complex layer tablets. Drug Dev. Ind. Pharm. 2000, 26:745-754.
11. Efentakis M., Peponaki C. Formulation study and evaluation of matrix and three-layer tablet sustaining drug delivery systems based on carbopols with isosorbite mononitrate. AAPS PharmSciTech 2008, 9:917-923.
12. Hertzberg R.W. Deformation and Fracture Mechanics of Engineering Materials 1996, Wiley, New York, pp. 42-44. 4th ed.
13. Kulkarni A., Bhatia M. Development and evaluation of regioselective bilayer floating tablets of atenolol and lovastatin for biphasic release profile. Iranian J. Pharm. Res. 2009, 8(1):15-25.
14. LaForce C., Gentile D.A., Skoner D.P. A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections. Postgrad. Med. 2008, 120:53-59.
15. Malzbender J., Steinbrech R.W. Mechanical methods to determine layer compliances within multilayered composites. J. Mater. Res. 2003, 18:1374-1382.
16. Nirmal J., Saisivam S., Peddanna C., Muralidharan S., Godwinkumar S., Nagarajan M. Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation. Chem. Pharm. Bull. 2008, 56:1455-1458.
17. Patra C.N., Kumar A.B., Pandit H.K., Singh S.P., Devi M.V. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Acta Pharm. 2007, 57:479-489.
18. Podczeck F. Investigations into the fracture mechanics of acetylsalicylic acid and lactose monohydrate. J. Mater. Sci. 2001, 36:4687-4693.
19. Podczeck F. Investigations into the mechanical strength anisotropy of Sorbitol Instant compacts made by uniaxial compression. Adv. Powder Technol. 2007, 18:361-379.
20. Podczeck F., Newton J.M. Determination of Young's modulus of different microcrystalline cellulose products. Pharmazie 1992, 47:387-388.
21. Podczeck F., Drake K.R., Newton J.M., Haririan I. The strength of bilayered tablets. Eur. J. Pharm. Sci. 2006, 29:361-366.
22. Stanley P. Mechanical testing of compacted powders. Int. J. Pharm. 2001, 227:27-38.
23. Train D. Transmission forces through a powder mass during the process of pelleting. Trans. Inst. Chem. Eng. 1957, 35:258-266.
24. York P., Bassam F., Rowe R.C., Roberts R.J. Fracture mechanics of microcrystalline cellulose. Int. J. Pharm. 1990, 66:143-147.