Considerations about the theoretically expected crushing strength of tablets from binary powder mixtures: Double layer tablets versus arithmetic additivity rule

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 64, Issue 3, 2006, Pages 343-350

  Belda, Petra M ^a   Mielck, Jobst B ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Additivity rule; Crushing strength; Double layer tablets; Parallel couplings; Powder mixtures

Indexed keywords

DIPYRONE; FLOWLAC; LACTOSE; MALTISORB; MALTITOL;

ARTICLE; CRUSHING STRENGTH; DRUG STABILITY; SIMULATION; TABLET; TABLET COMPRESSION; TABLET FORMULATION; TABLET MACHINE; TABLET PROPERTY; TABLET THICKNESS; VALIDITY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; COMPUTER SIMULATION; DIPYRONE; EXCIPIENTS; LACTOSE; MALTOSE; MODELS, CHEMICAL; POWDERS; SUGAR ALCOHOLS; TABLETS; TENSILE STRENGTH;

EID: 33750074734     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.06.007     Document Type: Article

References (15)

1. Fell J.T. Compaction properties of binary mixtures. In: Alderborn G., and Nyström C. (Eds). Pharmaceutical Powder Compaction Technology (1996), Marcel Dekker, New York, NY, USA 501-515
2. van Veen B., van der Voort Maarschalk K., Bolhuis G.K., Zuurman K., and Frijlink H.W. Tensile strength of tablets containing two materials with a different compaction behaviour. Int. J. Pharm. 203 (2000) 71-79
3. Vromans H., and Lerk C.F. Densification properties and compactibility of mixtures of pharmaceutical excipients with and without magnesium stearate. Int. J. Pharm. 46 (1988) 183-192
4. Kolarik J. A model for the yield strength of binary blends of thermoplastics. Polymer 35 (1994) 3631-3637
5. Kolarik J. Evaluation of the extent of interfacial debonding in polymer blends. Polymer 37 (1996) 887-891
6. van Veen B., van der Voort Maarschalk K., Bolhuis G.K., and Frijlink H.W. Predicting mechanical properties of compacts containing two components. Powder Technol. 139 (2004) 156-164
7. Belda P.M., and Mielck J.B. The difficulty in the assessment of the compression behaviour of powder mixtures: double layer tablets versus arithmetic additivity rule. Eur. J. Pharm. Biopharm. 60 (2005) 133-145
8. P.H. Krause, Einflüsse des Geschwindigkeitsverlaufs in Exzenter-Tablettiermaschinen auf die Verdichtungseigenschaften von pharmazeutischen Haufwerken, Ph.D. thesis, University of Hamburg, Germany, 1991.
9. Belda P.M., and Mielck J.B. The tabletting machine as an analytical instrument: qualification of the measuring devices for punch forces and validation of the calibration procedures. Eur. J. Pharm. Biopharm. 46 (1998) 381-395
10. Belda P.M., and Mielck J.B. The tabletting machine as an analytical instrument: qualification of the tabletting machine and the instrumentation with respect to the determination of punch separation and validation of the calibration procedures. Eur. J. Pharm. Biopharm. 47 (1999) 231-245
11. DIN 51301, Kraftmessgeräte für statische Kräfte zur Prüfung von Werkstoffprüfmaschinen, Beuth, Berlin, 1986.
12. DIN 1319-4, Grundlagen der Messtechnik - Teil 4: Auswertung von Messungen, Messunsicherheit, Beuth, Berlin, 1999.
13. Weise K., and Wöger W. Messunsicherheit und Messdatenauswertung (1999), Wiley-VCH, Weinheim 247-251
14. Rees J.E., Hersey J.A., and Cole E.T. The effect of rate of loading on the strength of tablets. J. Pharm. Pharmacol. 22 Suppl. (1970) 64S-69S
15. Edge S., Steele D.F., Chen A., Tobyn M.J., and Staniforth J.N. The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose. Int. J. Pharm. 200 (2000) 67-72