A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/ pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections

Postgraduate Medicine

Volumn 120, Issue 2, 2008, Pages 53-59

  LaForce, Craig ^a   Gentile, Deborah A ^b,c   Skoner, David P ^b,c  

^a North Carolina Clinical Research Inc   (United States)

^b ALLEGHENY GENERAL HOSPITAL   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Acute respiratory infection; Adjunctive therapy; Decongestants; Expectorants; Guaifenesin; Pseudoephedrine

Indexed keywords

MUCINEX D; PLACEBO; PSEUDOEPHEDRINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DECONGESTIVE AGENT; EXPECTORANT AGENT; GUAIFENESIN;

ADJUVANT THERAPY; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; FEMALE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; MULTICENTER STUDY; NAUSEA; NERVOUSNESS; PATIENT ASSESSMENT; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SIDE EFFECT; SUSTAINED DRUG RELEASE; TABLET FORMULATION; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VERTIGO; DELAYED RELEASE FORMULATION; DRUG COMBINATION; MIDDLE AGED; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADULT; ANTI-BACTERIAL AGENTS; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; EXPECTORANTS; FEMALE; GUAIFENESIN; HUMANS; MALE; MIDDLE AGED; NASAL DECONGESTANTS; PSEUDOEPHEDRINE; RESPIRATORY TRACT INFECTIONS; TREATMENT OUTCOME;

EID: 54049150885     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.3810/pgm.2008.07.1791     Document Type: Article

References (13)

1. File TM, Hadley JA. Rational use of antibiotics to treat respiratory tract infections. Am J Manag Care. 2002;8(8):713-727. (Pubitemid 34987578)
2. Taghizadeh F, Hadley JA, Osguthorpe JD. Pharmacological treatments for rhinosmusitis. Expert Opin Pharmacother. 2002;3(3):305-313.
3. Becker DG. Sinusitis. J Long Term Eff Med Implants. 2003;13(3):175-194.
4. Becker DG. Medical treatment of sinusitis. J Long Term Eff Med Implants. 2003;13(3):195-205. (Pubitemid 36807808)
5. Winstead W. Rhinosinusitis. Prim Care. 2003;30(1):137-154.
6. Tan R, Spector S. Pediatric sinusitis. Curr Allergy Asthma Rep. 2007;7(6):421-426. (Pubitemid 47629075)
7. Rosenfeld RM, Andes D, Bhattacharyya N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007;137(suppl 3):S1-S31. (Pubitemid 47302529)
8. Knutson D, Braun C. Diagnosis and management of acute bronchitis. Am Fam Physician. 2002;65(10):2039-2044.
9. Desrosiers M, Frenkiel S, Hamid QA, et al. Acute bacterial sinusitis in adults: management in the primary care selling. J Otolaryngol. 2002;31(suppl 2):2S2-2S14. (Pubitemid 36061544)
10. Scarupa MD, Kaliner MA. Adjuvant therapies in the treatment of acute and chronic rhinosmusitis. Clin Allergy Immunol. 2007;20:251-262.
11. Sharp HJ, Denman D, Puumala S, Leopold DA. Treatment of acute and chronic rhinosinusitis in the United States, 1999-2002. Arch Otolaryngol Head Neck Surg. 2007;133(3):260-265.
12. Ressel G. Principles of appropriate antibiotic use: part III. Acute rhinosinusitis. Am Fam Physician. 2001;64(4):685-686. (Pubitemid 32801491)
13. Lee PC, Jawad MS, Hull JD, West WH, Shaw K, Eccles R. The antitussive effect of placebo treatment on cough associated with acute upper respiratory infection. Psychosom Med. 2005;67(2):314-317. (Pubitemid 40410969)