Regional citrate anticoagulation is safe in intermittent high-flux haemodialysis treatment of children and adolescents with an increased risk of bleeding

Nephrology Dialysis Transplantation

Volumn 25, Issue 10, 2010, Pages 3337-3342

  Kreuzer, Martin ^a   Bonzel, Klaus Eugen ^b   Büscher, Rainer ^b   Offner, Gisela ^a   Ehrich, Jochen H H ^a   Pape, Lars ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

ACD A; acute renal failure; children; citrate dialysis; intermittent haemodialysis

Indexed keywords

CALCIUM; CALCIUM ION; DIALYSIS FLUID; GLUCONATE CALCIUM; HEPARIN;

ADOLESCENT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BLOOD FLOW VELOCITY; BODY SURFACE; CALCIUM BLOOD LEVEL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIALYSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EVALUATION; EXTRACORPOREAL CIRCULATION; FEASIBILITY STUDY; FEMALE; GERM CELL TUMOR; GOODPASTURE SYNDROME; GRAFT FAILURE; HEMODIALYSIS; HUMAN; MALE; OXALOSIS; PATIENT SAFETY; PRESCHOOL CHILD; PRIORITY JOURNAL; REGIONAL CITRATE ANTICOAGULATION; RETROSPECTIVE STUDY; SCHOOL CHILD; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ANTICOAGULANTS; CHILD; CHILD, PRESCHOOL; CITRIC ACID; FEMALE; HEMORRHAGE; HUMANS; MALE; RENAL DIALYSIS; RETROSPECTIVE STUDIES;

EID: 77957237351     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq225     Document Type: Article

References (37)

1. Davenport A. Anticoagulation options for pediatric hemodialysis. Hemodial Int 2003; 7: 168-176
2. Nuthall G, Skippen P, Daoust C et al. Citrate anticoagulation in a piglet model of pediatric continuous renal replacement therapy. Crit Care Med 2002; 30: 900-903
3. European Best Practice Guidelines Expert Group on Hemodialysis, European Renal Association. Section V. Chronic intermittent hae-modialysis and prevention of clotting in the extracorporeal system. Nephrol Dial Transplant 2002; 17: 63-71
4. Brophy PD, Somers MJ, Baum MA et al. Multi-centre evaluation of anticoagulation in patients receiving continuous renal replacement therapy (CRRT). Nephrol Dial Transplant 2005; 20: 1416-1421
5. Van De Wetering J, Westendorp RG, van der Hoeven JG et al. Heparin use in continuous renal replacement procedures: the struggle between filter coagulation and patient hemorrhage. J Am Soc Nephrol 1996; 7: 45-50
6. Lohr JW, Schwab SJ. Minimizing hemorrhagic complications in dialysis patients. J Am Soc Nephrol 1991; 2: 961-975
7. Janssen MJ, van der Meulen J. The bleeding risk in chronic haemo-dialysis. Preventive strategies in high-risk patients. Neth J Med 1996; 48: 198-207
8. Hörl WH. Thrombozytopathy and bleeding complications in uremia. Wien Klin Wochenschr 2006; 118: 134-150
9. Bock KR. Renal replacement therapy in pediatric critical care medicine. Curr Opin Pediatr 2005; 17: 368-371
10. Morita Y, Johnson RW, Dorn RE et al. Regional anticoagulation during hemodialysis using citrate. Am J Med Sci 1961; 242: 32-43
11. Pinnick RV, Wiegmann TB, Diederich DA. Regional citrate anticoa-gulation for hemodialysis in the patient at high risk for bleeding. N Engl J Med 1983; 308: 258-261
12. Mehta R, McDonald B, Aguilar M et al. Regional citrate anticoagu-lation for continuous arteriovenous hemodialysis in critically ill patients. Kidney Int 1990; 38: 976-981
13. Bunchman TE, Maxvold NJ, Barnett J et al. Pediatric hemofiltration: normocarb dialysate solution with citrate anticoagulation. Pe d i a t r Nephrol 2002; 17: 150-154
14. Bunchman TE, Maxvold NJ, Brophy PD. Pediatric convective hemo-filtration: normocarb replacement fluid and citrate anticoagulation. Am J Kidney Dis 2003; 42: 1248-1252
15. Chadha V, Garg U, Warady BA et al. Citrate clearance in children receiving continuous venovenous renal replacement therapy. Pediatr Nephrol 2002; 17: 819-824
16. Elhanan N, Skippen P, Nuthall G et al. Citrate anticoagulation in pediatric continuous venovenous hemofiltration. Pediatr Nephrol 2004; 19: 208-212
17. Gubensek J, Buturovic-Ponikvar J, Ponikvar R. Regional citrate antic-oagulation for single-needle hemodialysis: a prospective clinical study. Blood Purif 2007; 25: 454-456
18. Schneider M, Thomas K, Liefeldt L et al. Efficacy and safety of intermittent hemodialysis using citrate as anticoagulant: a prospective study. Clin Nephrol 2007; 68: 302-307
19. Symons JM, Chua AN, Somers MJ et al. Demographic characteristics of pediatric continuous renal replacement therapy: a report of the Prospective Pediatric Continuous Renal Replacement Therapy Registry. Clin J Am Soc Nephrol 2007; 2: 732-738
20. Kozik-Jaromin J, Nier V, Heemann U et al. Citrate pharmacokinetics and calcium levels during high-flux dialysis with regional citrate anticoagulation. Nephrol Dial Transplant 2009; 24: 2244-2251
21. Kreuzer M, Ahlenstiel T, Kanzelmeyer N et al. Management of regional citrate anticoagulation in pediatric high-flux dialysis: activated coagulation time versus post-filter ionized calcium. Pediatr Nephrol 2010 Mar 11. [Epub ahead of print]
22. Mitchell A, Daul AE, Beiderlinden M et al. A new system for regional citrate anticoagulation in continuous venovenous hemodialysis (CVVHD). Clin Nephrol 2003; 59: 106-114
23. Mateer FM, Greenman L, Danowski TS. Hemodialysis of the uremic child. AMA Am J Dis Child 1955; 89: 645-655
24. Fadrowski JJ, Frankenfield D, Amaral S et al. Children on long-term dialysis in the United States: findings from the 2005 ESRD clinical performance measures project. Am J Kidney Dis 2007; 50: 958-966
25. Hui-Stickle S, Brewer ED, Goldstein SL. Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. Am J Kidney Dis 2005; 45: 96-101
26. Kreuzer M, Ehrich JH, Pape L. Haemorrhagic complications in pae-diatric dialysis-dependent acute kidney injury: incidence and impact on outcome. Nephrol Dial Transplant 2010; 25: 1140-1146
27. Ataullakhanov F, Pohilko A, Sinauridze E. Calcium threshold in human plasma clotting kinetics. Thromb Res 1994; 75: 383-394
28. Calatzis A, Toepfer M, Schramm W et al. Citrate anticoagulation for extracorporeal circuits: effects on whole blood coagulation activation and clot formation. Nephron 2001; 89: 233-236
29. Van Der Voort PH, Postma SR, Kingma WP et al. An observational study on the effects of nadroparin-based and citrate-based continuous venovenous hemofiltration on calcium metabolism. Blood Purif 2007; 25: 267-273
30. Oudemans-Van Straaten HM, Bosman RJ, Koopmans M et al. Citrate anticoagulation for continuous venovenous hemofiltration. Crit Care Med 2009; 37: 545-552
31. Dzik W, Kirkley S. Citrate toxicity during massive blood transfusion. Transfus Med Rev 1988; 2: 76-94
32. Marquez J, Martin D, Virji M et al. Cardiovascular depression secondary to ionic hypocalcemia during hepatic transplantation in humans. Anesthesiology 1986; 65: 457-461
33. Scott VL, De Wolf AM, Kang Y et al. Ionized hypomagnesemia in patients undergoing orthotopic liver transplantation: a complication of citrate intoxication. Liver Transpl Surg 1996; 2: 343-347
34. Kishimoto M, Ohto H, Shikama Y et al. Treatment for the decline of ionized calcium levels during peripheral blood progenitor cell harvesting. Transfusion 2002; 42: 1340-1347
35. Bunker J, Bendixen H, Murphy A. Hemodynamic effects of intravenously administered sodium citrate. N Engl J Med 1962; 266: 372-377
36. Charney D, Salmond R. Cardiac arrest after hypertonic citrate an-ticoagulation for chronic hemodialysis. ASAIO Trans 1990; 36: M217-M219
37. Bakker AJ, Boerma EC, Keidel H et al. Detection of citrate overdose in critically ill patients on citrate-anticoagulated venovenous haemofiltration: use of ionised and total/ionised calcium. Clin Chem Lab Med 2006; 44: 962-966