Management of regional citrate anticoagulation in pediatric high-flux dialysis: Activated coagulation time versus post-filter ionized calcium

Pediatric Nephrology

Volumn 25, Issue 7, 2010, Pages 1305-1310

  Kreuzer, Martin ^a   Ahlenstiel, Thurid ^a   Kanzelmeyer, Nele ^a   Ehrich, Jochen H H ^a   Pape, Lars ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Children; Coagulation management; High flux hemodialysis; Post filter ionized calcium; Regional citrate anticoagulation

Indexed keywords

CALCIUM ION; CITRIC ACID; GLUCONATE CALCIUM;

ACTIVATED COAGULATION TIME; ADOLESCENT; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; BLOOD FLOW VELOCITY; CHILD; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HIGH FLUX DIALYSIS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PEDIATRICS; PRESCHOOL CHILD; PRESCRIPTION; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; REGIONAL CITRATE ANTICOAGULATION; RELIABILITY; RETROSPECTIVE STUDY; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; UREMIA;

ADOLESCENT; ANTICOAGULANTS; BLOOD COAGULATION; CALCIUM; CHILD; CHILD, PRESCHOOL; CITRIC ACID; DRUG MONITORING; FEMALE; FILTRATION; HUMANS; INFANT; INFANT, NEWBORN; IONS; KIDNEY FAILURE, CHRONIC; MALE; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; RENAL DIALYSIS; RETROSPECTIVE STUDIES; ROC CURVE; UREMIA; WHOLE BLOOD COAGULATION TIME;

EID: 77954535095     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-010-1483-4     Document Type: Article

References (29)

1. Morita Y, Johnson RW, Dorn RE, Hall DS (1961) Regional anticoagulation during hemodialysis using citrate. Am J Med Sci 242:32-43
2. Pinnick RV, Wiegmann TB, Diederich DA (1983) Regional citrate anticoagulation for hemodialysis in the patient at high risk for bleeding. N Engl J Med 308:258-261
3. Mehta R, McDonald B, Aguilar M, Ward DM (1990) Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients. Kidney Int 38:976-981
4. Gubensek J, Buturovic-Ponikvar J, Ponikvar R (2007) Regional citrate anticoagulation for single-needle hemodialysis: a prospective clinical study. Blood Purif 25:454-456
5. Schneider M, Thomas K, Liefeldt L, Kindgen-Milles D, Peters H, Neumayer HH, Morgera S (2007) Efficacy and safety of intermittent hemodialysis using citrate as anticoagulant: a prospective study. Clin Nephrol 68:302-307
6. Bunchman TE, Maxvold NJ, Barnett J, Hutchings A, Benfield MR (2002) Pediatric hemofiltration. Normocarb dialysate solution with citrate anticoagulation. Pediatr Nephrol 17:150-154
7. Bunchman TE, Maxvold NJ, Brophy PD (2003) Pediatric convective hemofiltration: Normocarb replacement fluid and citrate anticoagulation. Am J Kidney Dis 42:1248-1252
8. Chadha V, Garg U, Warady BA, Alon US (2002) Citrate clearance in children receiving continuous venovenous renal replacement therapy. Pediatr Nephrol 17:819-824
9. Elhanan N, Skippen P, Nuthall G, Krahn G, Seear M (2004) Citrate anticoagulation in pediatric continuous venovenous hemofiltration. Pediatr Nephrol 19:208-212
10. Symons JM, Chua AN, Somers MJ, Baum MA, Bunchman TE, Benfield MR, Brophy PD, Blowey D, Fortenberry JD, Chand D, Flores FX, Hackbarth R, Alexander SR, Mahan J, McBryde KD, Goldstein SL (2007) Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol 2:732-738
11. Ward DM (1997) The approach to anticoagulation in patients treated with extracorporeal therapy in the intensive care unit. Adv Ren Replace Ther 4:160-173
12. Ataullakhanov F, Pohilko A, Sinauridze E (1994) Calcium threshold in human plasma clotting kinetics. Thromb Res 75:383-394
13. Calatzis A, Toepfer M, Schramm W, Spannagl M, Schiffl H (2001) Citrate anticoagulation for extracorporeal circuits: effects on whole blood coagulation activation and clot formation. Nephron 89:233-236
14. Hattersley PG (1966) Activated coagulation time of whole blood. JAMA 196:436-440
15. Taneja R, Fernandes P, Marwaha G, Cheng D, Bainbridge D (2008) Perioperative coagulation management and blood conservation in cardiac surgery: a Canadian Survey. J Cardiothorac Vasc Anesth 22:662-669
16. Slight RD, Buell R, Nzewi OC, McClelland DB, Mankad PS (2008) A comparison of activated coagulation time-based techniques for anticoagulation during cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth 22:47-52
17. Martindale SJ, Shayevitz JR, D'Errico C (1996) The activated coagulation time: suitability for monitoring heparin effect and neutralization during pediatric cardiac surgery. J Cardiothorac Vasc Anesth 10:458-463
18. Hattersley PG (1971) The activated coagulation time of whole blood as a routine pre-operative sceening test. Calif Med 114:15-18
19. Siskin GP, Reiner E, Stainken BF, Dowling K, Dolen EG, Quarfordt S, Albons G (2001) Activated clotting time as a screening test prior to catheter-based cardiovascular procedures. Catheter Cardiovasc Interv 54:191-195
20. Davenport A (2003) Anticoagulation options for pediatric hemodialysis. Hemodial Int 7:168-176
21. Rani TR, Gopinath R (2008) An unusual cause of a prolonged activated coagulation time during cardiac surgery: congenital hypofibrinogenemia. J Cardiothorac Vasc Anesth 22:725-726
22. Chang RJ, Doherty TM, Goldberg SL (1998) How does warfarin affect the activated coagulation time? Am Heart J 136:477-479
23. Stefanidis I, Hägel J, Maurin N (1995) Influence of coagulation parameters on filter running time during continuous venovenous hemofiltration. Contrib Nephrol 116:145-149
24. Lord H, Jean N, Dumont M, Kassis J, Leblanc M (2002) Comparison between tinzaparin and standard heparin for chronic hemodialysis in a Canadian center. Am J Nephrol 22:58-66
25. Hörl WH (2006) Thrombocytopathy and bleeding complications in Uremia. Wien Klin Wochenschr 118:134-150
26. Nuthall G, Skippen P, Daoust C, Al-Jofan F, Seear M (2002) Citrate anticoagulation in a piglet model of pediatric continuous renal replacement therapy. Crit Care Med 30:900-903
27. Bakker AJ, Boerma EC, Keidel H, Kingma P, Van Der Voort PH (2006) Detection of citrate overdose in critically ill patients on citrate- anticoagulated venovenous hemofiltration: use of ionized and total/ionized calcium. Clin Chem Lab Med 44:962-966
28. Opatrný K, Richtrová P, Polanská K, Wirth J, Sefrna F, Brandl M, Falkenhagen D (2007) Citrate anticoagulation control by ionized calcium levels does not prevent hemostasis and complement activation during hemodialysis. Artif Organs 31:200-207
29. Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629-637