The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

Journal of Pharmacological and Toxicological Methods

Volumn 62, Issue 3, 2010, Pages 236-242

  Forster, Roy ^a   Bode, Gerd ^b   Ellegaard, Lars ^c   van der Laan, Jan Willem ^d  

^a CIT   (France)

^b Ellegaard Göttingen Minipigs A/S ^*  (Germany)

^c Ellegaard Gottingen Minipigs A S   (Denmark)

^d NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

FP6; Minipig; Recommendations; RETHINK; Toxicology

Indexed keywords

CHEMICAL COMPOUND; NEW DRUG;

ANIMAL TESTING REDUCTION; ANIMAL TESTING REFINEMENT; ANIMAL TESTING REPLACEMENT; ARTICLE; CONTROLLED STUDY; COST; DOG; FINANCE; GENETIC MANIPULATION; GENOMICS; MINIPIG; NONHUMAN; PRIMATE; TOXICITY TESTING;

ANIMAL USE ALTERNATIVES; ANIMAL WELFARE; ANIMALS; EUROPEAN UNION; GOVERNMENT REGULATION; HUMANS; MODELS, ANIMAL; RESEARCH DESIGN; SWINE; SWINE, MINIATURE; TOXICITY TESTS; XENOBIOTICS;

ANIMALIA; CANIS FAMILIARIS; PRIMATES;

EID: 77957226435     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2010.05.008     Document Type: Article

References (17)

1. Bartussek H. A Review of the animal needs index (ANI) for the assessment of animals' well-being in the housing systems for Austrian proprietary products and legislation. Livestock Production Science 1999, 61(2-3):179-192.
2. Berggren, K.F., Jensen, M. Moeller, & Boegh, Ingrid Brück (2008). Baggrundsincidensen of eksterne og viscerale kongenitale misdannelser i Göttingen minigrise. Koebenhavns Universitet, Institut for Produktionsdyr og Heste, Det Biovidenskabelige Fakultet for Fødevarer, Veterinærmedicin og Naturressourcer Veterinary thesis, January 2008.
3. Bode G, P Clausing, F Gervais, J Loegsted, J Luft, V Nogues, and J Sims, under the auspices of the Steering Group of the RETHINK Project 2010. The utility of the minipig as an animal model in regulatory toxicology, Journal Pharm Tox Methods. 62, 196-220 (this issue).
4. Bracke M.B.M., Metz J.H.M., Dijkhuizen A.A. Development of a decision support system to assessing farm animal welfare in relation to husbandry systems: Strategy and prototype. J. Agric. Environ. Ethics. 2001, 14:321-337.
5. Bracke M.B.M., Metz J.H.M., Spruijt B.M. Development of a decision support system to assess farm animal welfare. Acta Agric. Scand. Sect. A. Anim. Sci. 2001, 30:17-20.
6. Damm Jorgensen K., Kledal T.S.A., Svendsen O., Skakkeboek N.E. The Göttingen minipig as a model for studying effects on male fertility. Scand. J. Lab. Anim. Sci. 1998, 25(Supp. 1).
7. Ellegaard L, A Cunningham, S Edwards, N Grand, T Nevalainen, M Prescott and T Schuurman, under the auspices of the Steering Group of the RETHINK Project 2010. Welfare of the minipig with special reference to use in regulatory toxicology studies, Journal Pharm Tox Methods. 62, 167-183 (this issue).
8. Forster R, G Bode, L Ellegaard and J-W van der Laan, 2010, The RETHINK project, mini-pigs as models for the toxicity testing of new medicines and chemicals: an impact assessment, Journal Pharm Tox Methods. 62, 158-159 (this issue).
9. Forster R, P Ancian, M Fredholm, H Simianer and B Whitelaw, under the auspices of the Steering Group of the RETHINK Project 2010, The minipig as a platform for new technologies in toxicology, Journal Pharm Tox Methods. 62, 227-235 (this issue).
10. Krohn T.C., Ellegaard L.& Hansen, Kornerup A. A preliminary study of the impact of stocking density on the behaviour of group housed Göttingen minipigs. Scandinavian Journal of Laboratory Animal Science 2000, 27(4):203-210.
11. Lind N.M., Moustgaard A., Jelsing J., Vajta G., Cumming P., Hansen A.K. The use of pigs in neuroscience: Modeling brain disorders. Neurocsi. Biobehav. Rev. 2007, 31:728-751.
12. Simianer H., Köhn F. Genetic management of the Göttingen Minipig population. Journal Pharm Tox Methods 2010, 62:122-226. (this issue).
13. Smulders D., Verbeke G., Mormede P., Geers R. Validation of a behavioral observation tool to assess pig welfare. Physiology & Behavior 2006, 89(11):438-447.
14. Steinberg, M., Akers, W.A., Weeks, M.H., McCreesh, A.H., & Maibach, H.I., (1975). A comparison of test techniques based on rabbit and human skin responses to irritants with recommendations regarding the evaluation of mildly or moderately irritating compounds. In: H. Maibach, (Ed.), Animal Models in Dermatology (pp. I-II). Edinburgh: Churchill Livingstone.
15. van der Laan J-W, J Brightwell, P McAnulty, J Ratky and C Stark under the auspices of the Steering Group of the RETHINK Project 2010, Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products, Journal Pharm Tox Methods. 62, 184-195 (this issue).
16. Webster, J. (1994). Animal Welfare - a cool eye toward Eden. Blackwell Publishing.
17. Webster J, P Bollen, H Grimm and M Jennings, under the auspices of the Steering Group of the RETHINK Project, 2010, Ethical implications of using the minipig in regulatory toxicology studies, Journal Pharm Tox Methods. 62, 160-166 (this issue).