A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod

AIDS

Volumn 24, Issue 15, 2010, Pages 2331-2335

  Fox, Paul A ^a   Nathan, Mayura ^b   Francis, Nicholas ^c   Singh, Naveena ^d   Weir, Justin ^c   Dixon, Glen ^c   Barton, Simon E ^a   Bower, Mark ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^d BARTS HEALTH NHS TRUST   (United Kingdom)

Author keywords

anal intraepithelial neoplasia; high grade squamous intraepithelial lesion; imiquimod; low grade squamous intraepithelial lesion; placebo controlled studies

Indexed keywords

IMIQUIMOD; PLACEBO;

ADULT; ANUS TUMOR; ARTICLE; BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; CYTOLOGY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; FOLLOW UP; HIGH GRADE ANAL CANAL INTRAEPITHELIAL NEOPLASIA; HIGH GRADE SQUAMOUS INTRAEPITHELIAL LESION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LOW GRADE SQUAMOUS INTRAEPITHELIAL LESION; MAJOR CLINICAL STUDY; MALE; MALE HOMOSEXUAL; PRECANCER AND CANCER-IN-SITU; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTOSCOPY; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, CUTANEOUS; ADULT; AMINOQUINOLINES; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; DOUBLE-BLIND METHOD; HIV INFECTIONS; HIV-1; HOMOSEXUALITY, MALE; HUMANS; MALE;

EID: 77957220639     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32833d466c     Document Type: Article

References (10)

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