Human papillomavirus (HPV) viral load and HPV type in the clinical outcome of HIV-positive patients treated with imiquimod for anogenital warts and anal intraepithelial neoplasia

Journal of the European Academy of Dermatology and Venereology

Volumn 21, Issue 8, 2007, Pages 1054-1060

  Sanclemente, G ^a   Herrera, S ^a   Tyring, S K ^b   Rady, P L ^b   Zuleta, J J ^a   Correa, L A ^a   He, Q ^b   Wolff, J C ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b University of Texas Health Science Center at Houston   (United States)

Author keywords

AIN; Anogenital warts; HPV type; HPV viral load; Imiquimod

Indexed keywords

IMIQUIMOD;

ADULT; ANUS TUMOR; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; CONDYLOMA; DRUG EFFICACY; EPITHELIUM TUMOR; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT DURATION; TUMOR CLASSIFICATION; VIRUS DETECTION; VIRUS LOAD; VIRUS STRAIN; WART VIRUS;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; AMINOQUINOLINES; ANUS DISEASES; ANUS NEOPLASMS; CARCINOMA IN SITU; CONDYLOMATA ACUMINATA; GENITAL DISEASES, MALE; HUMANS; MALE; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; VIRAL LOAD;

EID: 34548178754     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2007.02169.x     Document Type: Article

References (35)

1. Chin-Hong PV, Vittinghoff E, Cranston RD et al. Age-related prevalence of anal cancer precursors in homosexual men: The EXPLORE study. J Natl Cancer Inst 2005; 97: 896-905.
2. Kiviat NB, Critchlow CW, Holmes KK et al. Association of anal dysplasia and human papillomavirus with immunosuppression and HIV infection among homosexual men. AIDS 1993; 7: 43-49.
3. Palefsky JM, Holly EA, Ralston ML et al. High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS 1998; 12: 495-503.
4. Lacey HB, Wilson GE, Tilston P et al. A study of anal intraepiethelial neoplasia in HIV positive homosexual men. Sex Transm Infect 1999; 75: 172-177.
5. Palefsky JM, Holly EA, Efirdc JT et al. Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS 2005; 19: 1407-1414.
6. Syrjanen SM, von Krogh G, Syrjanen KJ. Anal condylomas in men. 1. Histopathological and virological assessment. Genitourin Med 1989; 65: 216-224.
7. von Krogh G, Wikstrom A, Syrjanen K, Syrjanen S. Anal and penile condylomas in HIV-negative and HIV-positive men: Clinical, histological and virological characteristics correlated to therapeutic outcome. Acta Derm Venereol 1995; 75: 470-474.
8. Sobhani I, Walker F, Roudot-Thoraval F et al. Anal carcinoma: Incidence and effect of cumulative infections. AIDS 2004; 23: 1561-1569.
9. Ryan DP, Mayer RJ. Anal carcinoma: Histology, staging, epidemiology, treatment. Curr Opin Oncol 2000; 12: 345-352.
10. Gilson RJC, Shupack JL, Friedman-Kien AE et al. A randomized, controlled, safety study using imiquimod for the topical treatment of anogenital warts in HIV-infected patients. AIDS 1999; 13: 2397-2404.
11. Saiag P, Bourgault-Villada I, Pavlovic M, Roudier-Pujol C. Efficacy of imiquimod on external anogenital warts in HIV-infected patients previously treated by highly active antiretroviral therapy. AIDS 2002; 16: 1438-1440.
12. Kreuter A, Brockmeyer NH, Weissenborn SJ et al. 5% imiquimod suppositories decrease the DNA load of intra-anal HPV types 6 and 11 in HIV-infected men after surgical ablation of condylomata acuminata. Arch Dermatol 2006; 142: 243-244.
13. Fenger C, Nielsen VT. Dysplastic changes in the anal canal epithelium in minor surgical specimens. Acta Pathol Microbiol Scand 1981; 89: 463-465.
14. Fuessel Haws AL, He Q, Rady PL et al. Nested PCR with the PGMY09/11 and GP5+/6+ primer sets improves detection of HPV DNA in cervical samples. J Virol Methods 2004; 122: 87-93.
15. Resnick RM, Cornelissen MT, Wright DK et al. Detection and typing of human papillomavirus in archival cervical cancer specimens by DNA amplification with consensus primers. J Natl Cancer Inst 1990; 82: 1477-1484.
16. de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ. The use of general primers GP5 and GP6 elongated at their 3 ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 1995; 76: 1057-1062.
17. Gravitt PE, Peyton CL, Alessi TQ et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol 2000; 38: 357-361.
18. Lorincz AT, Reid R, Jenson AB et al. Human papillomavirus infection of the cervix. relative risk associations of 15 common anogenital types. Obstet Gynecol 1992; 79: 328-337.
19. Munoz N, Bosch FX, de Sanjose S et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-527.
20. Arany I, Evans T, Tyring SK. Tissue specific HPV expression and dowregulation of local immune responses in condylomas from HIV seropositive individuals. Sex Transm Infect 1998; 74: 349-353.
21. Breese PL, Jadson FN, Penley KA et al. Anal human papillomavirus infection among homosexual and bisexual men: Prevalence of type specific infecction and association with human inmunodeficiency virus. Sex Transm Dis 1995; 22: 7-14.
22. Palefsky JM, Holly EA, Ralston ML, Jay N. Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J Infect Dis 1998; 177: 361-367.
23. Kreuter A, Brockmeyer NH, Hochdorfer B et al. Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol 2005; 52: 603-608.
24. Wilkin TJ, Palmer S, Brudney KF, Chiasson MA, Wright TC. Anal intraepithelial neoplasia in heterosexual and homosexual HIV-positive men with access to antiretroviral therapy. J Infect Dis 2004; 190: 1685-1691.
25. Drobacheff C, Dupont P, Mougin C et al. Anal human papillomavirus DNA screening by Hybrid Capture II in human immunodeficiency virus-positive patients with or without anal intercourse. Eur J Dermatol 2003; 13: 367-371.
26. Voltz JM, Drobacheff C, Derancourt C et al. Papillomavirus-induced anogenital lesions in 121 HIV seropositive men. Clinical, histological, viral study, and evolution. Ann Dermatol Venereol 1999; 126: 424-429.
27. Palefsky JM, Holly EA, Ralston ML et al. Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 17: 320-326.
28. Cusini M, Salmaso F, Zerboni R et al. 5% Imiquimod cream for external anogenital warts in HIV-infected patients under HAART therapy. Int J STD AIDS 2004; 15: 17-20.
29. Wieland U, Weissenborn S, Brockmeyer N et al. Imiquimod treatment of AIN of HIV positive men leads to a drop of HPV DNA loads along with clinical and histological regression. 22nd International Papillomavirus Conference, 2-5 May 2005, Vancouver, British Columbia, Canada, Poster X 04.
30. Kreuter A, Hochdorfer B, Stucker M et al. Treatment of anal intraepithelial neoplasia in patients with acquired HIV with imiquimod 5% cream. J Am Acad Dermatol 2004; 50: 980-981.
31. De Marco F, Di Carlo A, Poggiali F, Muller A, Marcante ML. Detection of HPV in General ital condylomata: Correlation between viral load and clinical outcome. J Exp Clin Cancer Res 2001; 20: 377-383.
32. Che YM, Wang JB, Liu YH. Correlation between deoxyribonucleic acid loads of human papillomavirus and recurrence of condylomata acuminata. Int J STD AIDS 2005; 16: 605-607.
33. De Panfilis G, Melzani G, Mori G, Ghidini A, Graifemberghi S. Relapses after treatment of external genital warts are more frequent in HIV-positive patients than in HIV-negative controls. Sex Transm Dis 2002; 29: 121-125.
34. Kilewo CD, Urassa WK, Pallangyo K et al. Response to podophyllotoxin treatment of genital warts in relation to HIV-1 infection among patients in Dar es Salaam, Tanzania. Int J STD AIDS 1995; 6: 114-116.
35. Beutner KR, Ferenczy A. Therapeutic approaches to genital warts. Am J Med 1997; 102: 28-37.