Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men

Journal of Investigative Dermatology

Volumn 128, Issue 8, 2008, Pages 2078-2083

  Kreuter, Alexander ^a   Potthoff, Anja ^a   Brockmeyer, Norbert H ^a   Gambichler, Thilo ^a   Stücker, Markus ^a   Altmeyer, Peter ^a   Swoboda, Jochen ^b   Pfister, Herbert ^c   Wieland, Ulrike ^c  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b Institute of Cytology   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; IMIQUIMOD; TRICHLOROACETIC ACID; VIRUS DNA;

ANAL INTRAEPITHELIAL NEOPLASIA; ANOSCOPY; ANUS; ANUS TUMOR; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; DIAGNOSTIC IMAGING; FOLLOW UP; HISTOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK; SEXUAL BEHAVIOR; TIME; VIRUS TYPING; WART VIRUS;

EID: 47349120527     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.24     Document Type: Article

References (30)

1. Abbasakoor F, Boulos PB (2005) Anal intraepithelial neoplasia. Br J Surg 92:277-90
2. Arany I, Tyring SK, Stanley MA, Tomai MA, Miller RL, Smith MH et al. (1999) Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%. Antiviral Res 43:55-63
3. Berry JM, Palefsky JM, Welton ML (2004) Anal cancer and its precursors in HIV-positive patients: perspectives and management. Surg Oncol Clin N Am 13:355-73
4. Chang GJ, Berry JM, Jay N, Palefsky JM, Welton ML (2002) Surgical treatment of high-grade anal squamous intraepithelial lesions: a prospective study. Dis Colon Rectum 45:453-8
5. Chiao EY, Giordano TP, Palefsky JM, Tyring S, Serag HE (2006) Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin Infect Dis 43:223-33
6. Chin-Hong PV, Palefsky JM (2002) Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin Infect Dis 35:1127-34
7. Crothers BA (2005) The Bethesda System 2001: update on terminology and application. Clin Obstet Gynecol 48:98-107
8. Fenger C, Nielsen VT (1986) Precancerous changes in the anal canal epithelium in resection specimens. Acta Pathol Microbiol Immunol Scand 94:63-9
9. Fox PA (2006) Human papillomavirus and anal intraepithelial neoplasia. Curr Opin Infect Dis 19:62-6
10. Gagne SE, Jensen R, Polvi A, Da Costa M, Ginzinger D, Efird JT et al. (2005) High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia. J Acquir Immune Defic Syndr 40:182-9
11. Goldstone SE, Hundert JS, Huyett JW (2007) Infrared coagulator ablation of high-grade anal squamous intraepithelial lesions in HIV-negative males who have sex with males. Dis Colon Rectum 50:565-75
12. Goldstone SE, Kawalek AZ, Huyett JW (2005) Infrared coagulator: a useful tool for treating anal squamous intraepithelial lesions. Dis Colon Rectum 48:1042-54
13. Hessol NA, Pipkin S, Schwarcz S, Cress RD, Bacchetti P, Scheer S (2007) The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS. Am J Epidemiol 165:1143-53
14. Jacobs MV, Snijders PJ, van den Brule AJ, Helmerhorst TJ, Meijer CJ, Walboomers JM (1997) A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol 35:791-5
15. Klencke B, Matijevic M, Urban RG, Lathey JL, Hedley ML, Berry M et al. (2002) Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a phase I study of ZYC101. Clin Cancer Res 8:1028-37
16. Kreuter A, Brockmeyer NH, Hochdorfer B, Weissenborn SJ, Stucker M, Swoboda J et al. (2005) Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol 52:603-8
17. Lacey HB, Wilson GE, Tilston P, Wilkins EG, Bailey AS, Corbitt G et al. (1999) A study of anal intraepithelial neoplasia in HIV positive homosexual men. Sex Transm Infect 75:172-7
18. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV et al. (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518-27
19. Palefsky JM, Berry M, Jay N, Krogstad M, Da Costa M, Darragh TM et al. (2006) A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals. AIDS 20:1151-5
20. Palefsky JM, Holly EA, Efirdc JT, Da Costa M, Jay N, Berry JM et al. (2005) Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS 19:1407-14
21. Palefsky JM, Holly EA, Hogeboom CJ, Ralston ML, DaCosta MM, Botts R et al. (1998b) Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. J Acquir Immune Defic Syndr Hum Retrovirol 17:314-9
22. Palefsky JM, Holly EA, Ralston ML, Jay N (1998a) Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J Infect Dis 177:361-7
23. Pineda CE, Berry JM, Jay N, Palefsky JM, Welton ML (2007) High resolution anoscopy in the planned staged treatment of anal squamous intraepithelial lesions in HIV-negative patients. J Gastrointest Surg 11:1410-6
24. Sanclemente G, Herrera S, Tyring SK, Rady PL, Zuleta JJ, Correa LA et al. (2007) Human papillomavirus (HPV) viral load and HPV type in the clinical outcome of HIV-positive patients treated with imiquimod for anogenital warts and anal intraepithelial neoplasia. J Eur Acad Dermatol Venereol 21:1054-60
25. Schön MP, Schön M (2006) The small-molecule immune response modifier imiquimod - its mode of action and clinical use in the treatment of skin cancer. Expert Opin Ther Targets 10:69-76
26. van Poelgeest MI, van Seters M, van Beurden M, Kwappenberg KM, Heijmans-Antonissen C, Drijfhout JW et al. (2005) Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment. Clin Cancer Res 11:5273-80
27. Watson AJ, Smith BB, Whitehead MR, Sykes PH, Frizelle FA (2006) Malignant progression of anal intra-epithelial neoplasia. ANZ J Surg 76:715-7
28. Weissenborn SJ, Funke AM, Hellmich M, Mallmann P, Fuchs PG, Pfister HJ et al. (2003) Oncogenic human papillomavirus DNA loads in human immunodeficiency virus-positive women with high-grade cervical lesions are strongly elevated. J Clin Microbiol 41:2763-7
29. Welton MI, Amerhauser A, Litle V, Leavenworth J, Darraugh T, Palefsky J (2001) Anal Bowen's disease and high-grade squamous intraepithelial lesions are histologically and immunohistochemically indistinguishable. Dis Colon Rectum 44:A32
30. Wieland U, Brockmeyer NH, Weissenborn SJ, Hochdorfer B, Stucker M, Swoboda J et al. (2006) Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men. Arch Dermatol 142:1438-44