Quantification of midazolam, morphine and metabolites in plasma using 96-well solid-phase extraction and ultra-performance liquid chromatography - Tandem mass spectrometry

Biomedical Chromatography

Volumn 24, Issue 9, 2010, Pages 969-976

  Ahsman, Maurice J ^a   Van Der Nagel, Bart C ^a   Mathot, Ron A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

96 well plates; Mass spectrometry; Midazolam; Morphine; Ultra performance liquid chromatography

Indexed keywords

BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; METABOLITES; PHASE SEPARATION; PLASMA STABILITY;

96-WELL; 96-WELL PLATE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MIDAZOLAM; MORPHINE; PHARMACOKINETIC- PHARMACODYNAMIC STUDIES; SENSITIVE ASSAY; SOLID-PHASE EXTRACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

MASS SPECTROMETRY;

1 HYDROXYMIDAZOLAM; DRUG METABOLITE; HYDROXYMIDAZOLAM GLUCURONIDE; MIDAZOLAM; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHILD; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; PHYSICAL CHEMISTRY; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 77957205494     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1394     Document Type: Article

References (24)

1. Anonymous. Guidance for Industry - Bioanalytical Method Validation. Biopharmaceutics Coordinating Committee, Center for Drug Evaluation and Research, US Food and Drug Administration, 2001.
2. Anonymous. Morphine and its glucuronide metabolite in rat plasma by reverse-phase SPE. Waters Oasis Sample Extraction Products Application Notes, 98, 2003.
3. Bauer TM, Ritz R, Haberthur C, Ha HR, Hunkeler W, Sleight AJ, Scollo- Lavizzari G and Haefeli WE. Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet 1995; 346: 145-147.
4. Bengtsson J, Jansson B and Hammarlund-Udenaes M. On-line desalting and determination of morphine, morphine-3-glucuronide and morphine- 6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2005; 19: 2116-2122.
5. Bouwmeester NJ, Anderson BJ, Tibboel D and Holford NH. Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children. British Journal of Anaesthesiology 2004; 92: 208-217. (Pubitemid 38159658)
6. Churchwell MI, Twaddle NC, Meeker LR and Doerge DR. Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS. Journal of Chromatography B: Analytical Technology in Biomedicine and Life Sciences 2005; 825: 134-143.
7. de Wildt SN, de Hoog M, Vinks AA, van der Giesen E and van den Anker JN. Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Critical Care Medicine 2003; 31: 1952-1958.
8. Dominguez-Ramirez AM, Cortes-Arroyo AR, Pena MH, Aoki-Maki K, Lopez JR, Rios-Castaneda C and Lopez-Munoz FJ. High-performance liquid chromatographic assay for morphine in small plasma samples: application to pharmacokinetic studies in rats. Journal of Pharmaceutical and Biomedical Analysis 2006; 40: 1172-1178. (Pubitemid 43247455)
9. Guillarme D, Nguyen DT, Rudaz S and Veuthey JL. Recent developments in liquid chromatography - impact on qualitative and quantitative performance. Journal of Chromatography A 2007; 1149: 20-29. (Pubitemid 46627623)
10. Jabor VA, Coelho EB, Dos Santos NA, Bonato PS and Lanchote VL. A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: applications to drug metabolism. Journal of Chromatography B: Analytical Technology in Biomedicine and Life Sciences 2005; 822: 27-32.
11. Kumar A, Mann HJ and Remmel RP. Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma. Journal of Chromatography B: Analytical Technology in Biomedicine and Life Sciences 2007; 853: 287-293. (Pubitemid 46891370)
12. Li W, Luo S, Smith HT and Tse FL. Simultaneous determination of midazolam and 1′-hydroxymidazolam in human plasma by liquid chromatography with tandem mass spectrometry. Biomedical Chromatography 2007; 21: 841-851. (Pubitemid 47215144)
13. Link B, Haschke M, Wenk M and Krahenbuhl S. Determination of midazolam and its hydroxy metabolites in human plasma and oral fluid by liquid chromatography/electrospray ionization ion trap tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2007; 21: 1531-1540.
14. Matuszewski BK, Constanzer ML and Chavez-Eng CM. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Analytical Chemistry 2003; 75: 3019-3030.
15. Mulla H, Lawson G, Peek GJ, Firmin RK and Upton DR. Plasma concentrations of midazolam in neonates receiving extracorporeal membrane oxygenation. ASAIO Journal 2003; 49: 41-47. (Pubitemid 36105578)
16. Musshoff F, Trafkowski J, Kuepper U and Madea B. An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites. Journal of Mass Spectrometry 2006; 41: 633-640. (Pubitemid 44023118)
17. Peeters MY, Prins SA, Knibbe CA, Dejongh J, Mathot RA, Warris C, van Schaik RH, Tibboel D and Danhof M. Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery. Anesthesiology 2006; 105: 1135-1146.
18. Peters JW, Anderson BJ, Simons SH, Uges DR and Tibboel D. Morphine metabolite pharmacokinetics during venoarterial extra corporeal membrane oxygenation in neonates. Clinical Pharmacokinetics 2006; 45: 705-714.
19. Plumb R, Castro-Perez J, Granger J, Beattie I, Joncour K and Wright A. Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 2004; 18: 2331-2337. (Pubitemid 39297371)
20. Rentsch KM. Clinical relevance of the quantification of alpha-hydroxymidazolam and/or its glucuronide. Toxichem und Krimtech 2006; 73: 11-13.
21. Simons SH and Anand KJ. Pain control: opioid dosing, population kinetics and side-effects. Seminars in Fetal and Neonatal Medicine 2006; 11: 260-267.
22. Taylor K and Elliott S. A validated hybrid quadrupole linear ion-trap LC-MS method for the analysis of morphine and morphine glucuronides applied to opiate deaths. Forensic Science International 2009; 187: 34-41.
23. van Rij KM, Compas D, Swart EL, de Goede PN and Touw DJ. Reversed-phase ion-pair HPLC method for the direct analysis of 1-OH midazolam glucuronide in human serum. Therapeutic Drug Monitoring 1999; 21: 416-420. (Pubitemid 29350420)
24. Wood M and Morris M. Quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in biological samples by LC/MS/ MS, Waters Application Brief, Clinical Applications Group, Waters Corp., Manchester, 2003.