Importance of the circumferential extent of tumors and clinical lymph node status as prognostic factors after preoperative chemoradiotherapy and surgery in patients with rectal cancer

Tumori

Volumn 96, Issue 4, 2010, Pages 568-576

  Yoon, Won Sup ^a   Park, Won ^b   Choi, Doo Ho ^b   Ahn, Yong Chan ^b   Chun, Ho Kyung ^b   Lee, Woo Yong ^b   Yun, Seong Hyeon ^b   Kang, Won Ki ^b   Lim, Ho Yeong ^b   Park, Young Suk ^b  

^a Korea University Ansan Hospital   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Circumferential extent; Lymph nodes; Preoperative chemoradiotherapy; Prognostic factors; Rectal cancer

Indexed keywords

CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; FLUOROURACIL; TEGAFUR; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER STAGING; CANCER SURGERY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OVERALL SURVIVAL; PREOPERATIVE CARE; RADIATION DOSE; RECTUM CANCER; TREATMENT OUTCOME; TUMOR VOLUME; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; BLOOD; LYMPH NODE METASTASIS; MIDDLE AGED; PATHOLOGY; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS; RECTAL NEOPLASMS; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SURVIVAL;

ADULT; AGED; CARCINOEMBRYONIC ANTIGEN; CHEMOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 77957193986     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089161009600409     Document Type: Article

References (32)

1. Compton C, Fenoglio-Preiser CM, Pettigrew N, Fielding LP: American Joint Committee on Cancer Prognostic Factors Consensus Conference: Colorectal Working Group. Cancer, 88: 1739-1757, 2000. (Pubitemid 30183160)
2. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med, 351: 1731-1740, 2004.
3. Valentini V, Aristei C, Glimelius B, Minsky BD, Beets-Tan R, Borras JM, Haustermans K, Maingon P, Overgaard J, Pahlman L, Quirke P, Schmoll HJ, Sebag-Montefiore D, Taylor I, Van Cutsem E, Van deVelde C, Cellini N, Latini P: Multidisciplinary Rectal Cancer Management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2). Radiother Oncol, 92: 148-163, 2009.
4. Valentini V, Beets-Tan R, Borras JM, Krivokapic Z, Leer JW, Pahlman L, Rodel C, Schmoll HJ, Scott N, Velde CV, Verfaillie C: Evidence and research in rectal cancer. Radiother Oncol, 87: 449-474, 2008.
5. Dworak O, Keilholz L, Hoffmann A: Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis, 12: 19-23, 1997. (Pubitemid 27138353)
6. Garcia-Aguilar J, Hernandez de Anda E, Sirivongs P, Lee SH, Madoff RD, Rothenberger DA: A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated bymesorectal excision. Dis Colon Rectum, 46: 298-304, 2003. (Pubitemid 36331646)
7. Rodel C, Martus P, Papadoupolos T, Fuzesi L, Klimpfinger M, Fietkau R, Liersch T, Hohenberger W, Raab R, Sauer R, Wittekind C: Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol, 23: 8688-8696, 2005. (Pubitemid 46211512)
8. Theodoropoulos G, Wise WE, Padmanabhan A, Kerner BA, Taylor CW, Aguilar PS, Khanduja KS: T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum, 45: 895-903, 2002. (Pubitemid 34761469)
9. Pucciarelli S, Toppan P, Friso ML, Russo V, Pasetto L, Urso E, Marino F, Ambrosi A, Lise M: Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Dis Colon Rectum, 47: 1798-1807, 2004. (Pubitemid 40064422)
10. Veenhof AA, Kropman RH, Engel AF, Craanen ME, Meijer S, Meijer OW, van der Peet DL, Cuesta MA: Preoperative radiation therapy for locally advanced rectal cancer: a comparison between two different time intervals to surgery. Int J Colorectal Dis, 22: 507-513, 2007. (Pubitemid 46488055)
11. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, Morrow M: AJCC Cancer Staging Manual, 6th edn, pp 113-123, Springer, New York, 2002.
12. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Statist Assoc, 53: 457-481, 1958.
13. Cox DR: Regression models and life tables. J Roy Stat Soc Series B, 34: 187-220, 1972.
14. Nagtegaal ID, Quirke P: What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol, 26: 303-312, 2008.
15. Detry RJ, Kartheuser AH, Lagneaux G, Rahier J: Preoperative lymph node staging in rectal cancer: a difficult challenge. Int J Colorectal Dis, 11: 217-221, 1996. (Pubitemid 26382038)
16. Dworak O: Number and size of lymph nodes and node metastases in rectal carcinomas. Surg Endosc, 3: 96-99, 1989.
17. Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG: High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol, 52: 78-83, 2004.
18. Koh DM, Chau I, Tait D, Wotherspoon A, Cunningham D, Brown G: Evaluating mesorectal lymph nodes in rectal cancer before and after neoadjuvant chemoradiation using thin-section T2-weighted magnetic resonance imaging. Int J Radiat Oncol Biol Phys, 71: 456-461, 2008.
19. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Wolff RA, Eng C, Krishnan S, Janjan NA, Crane CH: Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer, 109: 1750-1755, 2007. (Pubitemid 46668536)
20. Yoon SM, Kim DY, Kim TH, Jung KH, Chang HJ, Koom WS, Lim SB, Choi HS, Jeong SY, Park JG: Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys, 69: 1167-1172, 2007. (Pubitemid 47625840)
21. Diaz-Gonzalez JA, Calvo FA, Cortes J, Garcia-Sabrido JL, Gomez-Espi M, Del Valle E, Munoz-Jimenez F, Alvarez E: Prognostic factors for disease-free survival in patients with T3-4 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation. Int J Radiat Oncol Biol Phys, 64: 1122-1128, 2006. (Pubitemid 43295308)
22. Lin AY, Wong WD, Shia J, Minsky BD, Temple LK, Guillem JG, Paty PB, Weiser MR: Predictive clinicopathologic factors for limited response of T3 rectal cancer to combined modality therapy. Int J Colorectal Dis, 23: 243-249, 2008.
23. Kim NK, Baik SH, Min BS, Pyo HR, Choi YJ, Kim H, Seong J, Keum KC, Rha SY, Chung HC: A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation. Int J Radiat Oncol Biol Phys, 67: 204-210, 2007. (Pubitemid 44959490)
24. Kim YH, Kim DY, Kim TH, Jung KH, Chang HJ, Jeong SY, Sohn DK, Choi HS, Ahn JB, Kim DH, Lim SB, Lee JS, Park JG: Usefulness of magnetic resonance volumetric evaluation in predicting response to preoperative concurrent chemoradiotherapy in patients with resectable rectal cancer. Int J Radiat Oncol Biol Phys, 62: 761-768, 2005.
25. Das P, Lin EH, Bhatia S, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Delclos ME, Krishnan S, Janjan NA, Crane CH: Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5- fluorouracil for rectal cancer: amatched-pair analysis. Int J Radiat Oncol Biol Phys, 66: 1378-1383, 2006.
26. de la Torre A, Garcia-Berrocal MI, Arias F, Marino A, Valcarcel F, Magallon R, Regueiro CA, Romero J, Zapata I, de la Fuente C, Fernandez-Lizarbe E, Vergara G, Belinchon B, Veiras M, Moleron R, Millan I: Preoperative chemoradiotherapy for rectal cancer: randomized trial comparing oral uracil and tegafur and oral leucovorin vs. intravenous 5- fluorouracil and leucovorin. Int J Radiat Oncol Biol Phys, 70: 102-110, 2008. (Pubitemid 350251034)
27. Kim DY, Jung KH, Kim TH, Kim DW, Chang HJ, Jeong JY, Kim YH, Son SH, Yun T, Hong CW, Sohn DK, Lim SB, Choi HS, Jeong SY, Park JG: Comparison of 5-fluorouracil/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys, 67: 378-384, 2007. (Pubitemid 46108315)
28. Kwok H, Bissett IP, Hill GL: Preoperative staging of rectal cancer. Int J Colorectal Dis, 15: 9-20, 2000.
29. Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J: Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging - a meta-analysis. Radiology, 232: 773-783, 2004.
30. Kantorova I, Lipska L, Belohlavek O, Visokai V, Trubac M, Schneiderova M: Routine (18)F-FDG PET preoperative staging of colorectal cancer: comparison with conventional staging and its impact on treatment decision making. J Nucl Med, 44: 1784-1788, 2003.
31. Bonnen M, Crane C, Vauthey JN, Skibber J, Delclos ME, Rodriguez-Bigas M, Hoff PM, Lin E, Eng C, Wong A, Janjan NA, Feig BW: Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients. Int J Radiat Oncol Biol Phys, 60: 1098-1105, 2004.
32. Habr-Gama A, Perez RO, Nadalin W, Sabbaga J, Ribeiro U, Jr, Silva e Sousa AH, Jr., Campos FG, Kiss DR, Gama-Rodrigues J: Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg, 240: 711-717; discussion 717-718, 2004.