Novel mechanism of reducing tumourigenesis: Upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition

European Journal of Cancer

Volumn 46, Issue 15, 2010, Pages 2806-2820

  Habib, Samy L ^a,b   Kasinath, Balakuntalam S ^b   Arya, Ruth Rector ^b   Vexler, Sandra ^b   Velagapudi, Chakradhar ^b  

^a GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

AMPK; NF YA; OGG1; p70S6K; Rapamycin

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 8 OXOGUANOSINE DNA GLYCOSYLTRANSFERASE 1; DNA; DNA GLYCOSYLTRANSFERASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LUCIFERASE; MAMMALIAN TARGET OF RAPAMYCIN; NUCLEAR FACTOR Y; RAPAMYCIN; S6 KINASE; SERINE; THREONINE; TUBERIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CARCINOGENESIS; CELL STRAIN; CELL STRAIN 786 O; CELL STRAIN HK 2; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; FIBROBLAST; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECOMBINANT PLASMID; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DNA GLYCOSYLASES; DNA REPAIR ENZYMES; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL CELLS; HUMANS; IMMUNOBLOTTING; KIDNEY NEOPLASMS; KIDNEY TUBULES, PROXIMAL; MALE; MICE; PROTEIN KINASES; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 77957190952     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.06.117     Document Type: Article

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