Site-specific investigation of the steady-state kinetics and dynamics of the multistep binding of bile acid molecules to a lipid carrier protein

Chemistry - A European Journal

Volumn 16, Issue 37, 2010, Pages 11300-11310

  Cogliati, Clelia ^a,b   Ragona, Laura ^a   D'Onofrio, Mariapina ^b   Günther, Ulrich ^c   Whittaker, Sara ^c   Ludwig, Christian ^c   Tomaselli, Simona ^a   Assfalg, Michael ^b   Molinari, Henriette ^b  

^a CNR   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Binding mechanisms; Line shape analysis; Lipids; Molecular recognition; NMR spectroscopy

Indexed keywords

BILE ACID; BILE SALTS; BINDING CAVITY; BINDING MECHANISMS; BOUND STATE; CONFORMATIONAL SELECTION; KINETIC ANALYSIS; LIGAND BINDING; LIGAND-PROTEIN BINDING; LINE-SHAPE ANALYSIS; LIPID CARRIERS; MULTI-SITE; MULTI-STEP; MULTI-STEP MECHANISM; NMR SPECTROSCOPY; PROTEIN DYNAMICS; RECOGNITION PROCESS; SITE-SPECIFIC; STEADY-STATE KINETICS; TIME-SCALES; UPTAKE MECHANISM;

ACIDS; BIOCHEMISTRY; BODY FLUIDS; CONFORMATIONS; LIGANDS; LIPIDS; MACROMOLECULES; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

DYNAMICS;

BILE ACID; CARRIER PROTEIN;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMPUTER PROGRAM; KINETICS; NUCLEAR MAGNETIC RESONANCE;

BILE ACIDS AND SALTS; CARRIER PROTEINS; KINETICS; MODELS, CHEMICAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SOFTWARE;

EID: 77957188861     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201000498     Document Type: Article

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