Genetic repositories for the study of major psychiatric conditions: What do we know about ethnic minorities' genetic vulnerability

Molecular Psychiatry

Volumn 15, Issue 10, 2010, Pages 970-975

  Oquendo, M A ^a   Canino, G ^b   Lehner, T ^c   Licinio, J ^d  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d Australian National University   (Australia)

Author keywords

diversity; DNA; race

Indexed keywords

AFRICAN AMERICAN; ASIAN AMERICAN; ETHNIC GROUP; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; GENOTYPE; HISPANIC; HUMAN; MENTAL DISEASE; PHENOTYPE; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW;

ETHNIC GROUPS; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MENTAL DISORDERS; NATIONAL INSTITUTE OF MENTAL HEALTH (U.S.); UNITED STATES;

EID: 77957147510     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2010.11     Document Type: Review

References (42)

1. Kendler KS. Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 2001; 58: 1005-1014.
2. Uhl GR, Grow RW. The burden of complex genetics in brain disorders. Arch Gen Psychiatry 2004; 61: 223-229.
3. Regier DA, Narrow WE, Kuhl EA, Kupfer DJ. The conceptual development of DSM-V. Am J Psychiatry 2009; 166: 645-650.
4. Abdolmaleky HM, Thiagalingam S, Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J Pharmacogenomics 2005; 5: 149-160.
5. Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N et al. Assessing the impact of population stratification on genetic association studies. Nat Genet 2004; 36: 388-393.
6. Talkowski ME, Bamne M, Mansour H, Nimgaonkar VL. Dopamine genes and schizophrenia: case closed or evidence pending? Schizophr Bull 2007; 33: 1071-1081.
7. Lundorf MD, Buttenschon HN, Foldager L, Blackwood DH, Muir WJ, Murray V et al. Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2005; 135B: 94-101.
8. Schumacher J, Kaneva R, Jamra RA, Diaz GO, Ohlraun S, Milanova V et al. Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24. Am J Hum Genet 2005; 77: 1102-1111.
9. Lerer B, Macciardi F, Segman RH, Adolfsson R, Blackwood D, Blairy S et al. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Mol Psychiatry 2001; 6: 579-585.
10. Oquendo MA, Ellis SP, Greenwald S, Malone KM, Weissman MM, Mann JJ. Ethnic and sex differences in suicide rates relative to major depression in the United States. Am J Psychiatry 2001; 158: 1652-1658.
11. Kirkbride JB, Fearon P, Morgan C, Dazzan P, Morgan K, Tarrant J et al. Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Arch Gen Psychiatry 2006; 63: 250-258.
12. Scirica CV, Celedon JC. Genetics of asthma: potential implications for reducing asthma disparities. Chest 2007; 132(5 Suppl): 770S-781S.
13. Ducci F, Roy A, Shen PH, Yuan Q, Yuan NP, Hodgkinson CA et al. Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry 2009; 166: 1031-1040.
14. Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with asthma: genetic insights. Proc Am Thorac Soc 2007; 4: 58-68.
15. Kinney DK, Teixeira P, Hsu D, Napoleon SC, Crowley DJ, Miller A et al. Relation of schizophrenia prevalence to latitude, climate, fish consumption, infant mortality, and skin color: a role for prenatal vitamin D deficiency and infections? Schizophr Bull 2009; 35: 582-595.
16. Alderete E, Vega WA, Kolody B, guilar-Gaxiola S. Effects of time in the United States and Indian ethnicity on DSM-III-R psychiatric disorders among Mexican Americans in California. J Nerv Ment Dis 2000; 188: 90-100.
17. Alegria M, Canino G, Stinson FS, Grant BF. Nativity and DSM-IV psychiatric disorders among Puerto Ricans, Cuban Americans, and non-Latino Whites in the United States: results from the National Epidemiologic survey on Alcohol and related conditions. J Clin Psychiatry 2006; 67: 56-65.
18. US Census Bureau. Annual estimates of the resident population by sex, race, and hispanic origin for the United States: April 1 2000 to July 1 2008 (NC-EST2008-03). US Census Bureau, Population Division 2009 May 13 [cited 15 July 2009]; available from: www.census.gov/popest/national/asrh/NC-EST2008-srh. html.
19. Escamilla M, Hare E, Dassori AM, Peralta JM, Ontiveros A, Nicolini H et al. A schizophrenia gene locus on chromosome 17q21 in a new set of families of Mexican and Central American ancestry: evidence from the NIMH Genetics of schizophrenia in Latino populations study. Am J Psychiatry 2009; 166: 442-449.
20. Mellman TA, Alim T, Brown DD, Gorodetsky E, Buzas B, Lawson WB et al. Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population. Depress Anxiety 2009; 26: 993-997.
21. Dong C, Wong ML, Licinio J. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Mol Psychiatry 2009; 14: 1105-1118.
22. Talkowski ME, McClain L, Allen T, Bradford LD, Calkins M, Edwards N et al. Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 560-569.
23. Sullivan PF, Lin D, Tzeng JY, van den OE, Perkins D, Stroup TS et al. Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry 2008; 13: 570-584.
24. Shavers VL, Lynch CF, Burmeister LF. Racial differences in factors that influence the willingness to participate in medical research studies. Ann Epidemiol 2002; 12: 248-256.
25. Wendler D, Kington R, Madans J, Van WG, Christ-Schmidt H, Pratt LA et al. Are racial and ethnic minorities less willing to participate in health research? PLoS Med 2006; 3: e19.
26. Pentz RD, Billot L, Wendler D. Research on stored biological samples: views of African American and White American cancer patients. Am J Med Genet A 2006; 140: 733-739.
27. Chen DT, Rosenstein DL, Muthappan P, Hilsenbeck SG, Miller FG, Emanuel EJ et al. Research with stored biological samples: what do research participants want? Arch Intern Med 2005; 165: 652-655.
28. Coors ME, Raymond KM. Substance use disorder genetic research: investigators and participants grapple with the ethical issues. Psychiatr Genet 2009; 19: 83-90.
29. Rathore SS, Krumholz HM. Race, ethnic group, and clinical research. BMJ 2003; 327: 763-764.
30. Choudhry S, Seibold MA, Borrell LN, Tang H, Serebrisky D, Chapela R et al. Dissecting complex diseases in complex populations: asthma in Latino Americans. Proc Am Thorac Soc 2007; 4: 226-233.
31. Wang S, Ray N, Rojas W, Parra MV, Bedoya G, Gallo C et al. Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet 2008; 4: e1000037.
32. Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosley T et al. Admixture mapping for hypertension loci with genome-scan markers. Nat Genet 2005; 37: 177-181.
33. Adeyemo A, Rotimi C. Genetic variants associated with complex human diseases show wide variation across multiple populations. Public Health Genomics 2009; 13: 72-79.
34. Licinio J, Dong C, Wong ML. Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry 2009; 66: 488-497.
35. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 2008; 320: 539-543.
36. Agarwal DP, Goedde HW. Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 1992; 2: 48-62.
37. Alegria M, Mulvaney-Day N, Woo M, Torres M, Gao S, Oddo V. Correlates of past-year mental health service use among Latinos: results from the National Latino and Asian American Study. Am J Public Health 2007; 97: 76-83.
38. Hussain-Gambles M, Atkin K, Leese B. Why ethnic minority groups are under-represented in clinical trials: a review of the literature. Health Soc Care Community 2004; 12: 382-388.
39. Institute of Medicine. In the Nation's Compelling Interest: Ensuring Diversity In The Health Care Workforce. Institute of Medicine, National Academy of Sciences: Washington DC, 2004.
40. National Institute of Health [NIH]. US Department of health and human services public health service. Application for Public Health Service Grant PHS 398. 2004 Available from http://grants.nih.gov/grants/funding/phs398/phs398. html.
41. National Research Council [NRC]. Assessment of NIH minority research and training programs: phase 3. National Research Council. 2005 Available from: http://books.nap.edu/openbook. php?record-id=11329&page=R1.
42. National Sciences Foundation. Minority postdoctoral research fellowships and supporting activities. Program solicitation NSF 00-139. 2000 Available from: http://www.nsf.gov/pubs/2001/nsf00139/nsf00139.html.