Genetics of menstrual migraine: The molecular evidence

Current Pain and Headache Reports

Volumn 14, Issue 5, 2010, Pages 389-395

  Colson, Natalie ^a   Fernandez, Francesca ^a   Griffiths, Lyn ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Genetics; Hormones; Menstrual migraine; Migraine

Indexed keywords

ANDROGEN RECEPTOR; CYTOCHROME P450; ESTROGEN; ESTROGEN RECEPTOR; FOLLITROPIN RECEPTOR; PROGESTERONE RECEPTOR; RECEPTOR INTERACTING PROTEIN 140; SEROTONIN AGONIST; SEX HORMONE; STEROID HORMONE; STEROID RECEPTOR;

ENVIRONMENTAL FACTOR; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEREDITY; HORMONE ACTION; HUMAN; MENSTRUAL MIGRAINE; PHENOTYPE; REVIEW;

EVIDENCE-BASED MEDICINE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GONADAL STEROID HORMONES; HUMANS; MENSTRUAL CYCLE; MIGRAINE DISORDERS; PREMENSTRUAL SYNDROME; RISK REDUCTION BEHAVIOR;

EID: 77957122126     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-010-0129-3     Document Type: Review

References (55)

1. EG Couturier MA Bomhof AK Neven NP van Duijn 2003 Menstrual migraine in a representative Dutch population sample: prevalence, disability and treatment Cephalalgia 23 302 308 1:STN:280:DC%2BD3s3ivFaktA%3D%3D 10.1046/j.1468-2982. 2003.00516.x 12716349
2. EA MacGregor 1996 "Menstrual" migraine: towards a definition Cephalalgia 16 11 21 1:STN:280:DyaK28vitlSqsQ%3D%3D 10.1046/j.1468-2982.1996. 1601011.x 8825694
3. RB Lipton WF Stewart 1997 Prevalence and impact of migraine Neurol Clin 15 1 13 1:STN:280:DyaK2s3htFeqtw%3D%3D 10.1016/S0733-8619(05)70291-7 9058393
4. S Gupta S Mehrotra CM Villalón, et al. 2007 Potential role of female sex hormones in the pathophysiology of migraine Pharmacol Ther 113 321 340 1:CAS:528:DC%2BD2sXhtVCgtL4%3D 10.1016/j.pharmthera.2006.08.009 17069890 This review details the changes in migraine throughout the female reproductive cycle and discusses the vascular and neuronal effects of sex hormones and how they may play a role in migraine
5. EA MacGregor H Chia RC Vohrah M Wilkinson 1990 Migraine and menstruation: a pilot study Cephalalgia 10 305 310 1:STN:280:DyaK3M7ksF2rsA%3D%3D 10.1046/j.1468-2982.1990.1006305.x 2289231
6. EA MacGregor 2004 Oestrogen and attacks of migraine with and without aura Lancet Neurol 3 354 361 1:CAS:528:DC%2BD2cXltlCqt70%3D 10.1016/S1474-4422(04) 00768-9 15157850
7. Headache Classification Subcommittee of the International Headache Society 2004 The International Classification of Headache Disorders: 2nd edition Cephalalgia 24 Suppl 1 1 60
8. L Dennerstein C Morse G Burrows, et al. 1988 Menstrual migraine: a double-blind trial of percutaneous estradiol Gynecol Endocrinol 2 113 120 1:STN:280:DyaL1M%2Fks1Kltw%3D%3D 10.3109/09513598809023619 3055819
9. TA Smitherman ED Kolivas 2010 Resolution of menstrually related migraine following aggressive treatment for breast cancer Headache 50 485 488 10.1111/j.1526-4610.2009.01594.x 20039954
10. BW Somerville 1972 The role of estradiol withdrawal in the etiology of menstrual migraine Neurology 22 355 365 1:STN:280:DyaE387lsVyltw%3D%3D 5062827
11. MT Epstein JM Hockaday TD Hockaday 1975 Migraine and reporoductive hormones throughout the menstrual cycle Lancet 1 543 548 1:STN:280: DyaE2M7hsl2lsw%3D%3D 10.1016/S0140-6736(75)91558-5 47017
12. V Ulrich M Gervil KO Kyvik, et al. 1999 Evidence of a genetic factor in migraine with aura: a population-based Danish twin study Ann Neurol 45 242 246 1:STN:280:DyaK1M7kt1OgsQ%3D%3D 10.1002/1531-8249(199902)45:2<242::AID- ANA15>3.0.CO;2-1 9989627
13. M Gervil V Ulrich KO Kyvik, et al. 1999 Migraine without aura: a population-based twin study Ann Neurol 46 606 611 1:STN:280:DyaK1Mvkt1amtw%3D%3D 10.1002/1531-8249(199910)46:4<606::AID-ANA8>3.0.CO;2-O 10514097
14. M Gervil V Ulrich J Kaprio, et al. 1999 The relative role of genetic and environmental factors in migraine without aura Neurology 53 995 999 1:STN:280:DyaK1MvisVGktQ%3D%3D 10496258
15. EJ Mulder C Van Baal D Gaist, et al. 2003 Genetic and environmental influences on migraine: a twin study across six countries Twin Res 6 422 431 10.1375/136905203770326420 14624726
16. VT Martin M Behbehani 2006 Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis: part I Headache 46 3 23 10.1111/j.1526-4610.2006.00309.x 16412147 This comprehensive review details the effects of steroid hormones in brain pathways believed to be involved in migraine
17. B Stoffel-Wagner 2003 Neurosteroid biosynthesis in the human brain and its clinical implications Ann N Y Acad Sci 1007 64 78 1:CAS:528: DC%2BD2cXisFChu7k%3D 10.1196/annals.1286.007 14993041
18. NA Compagnone SH Mellon 2000 Neurosteroids: biosynthesis and function of these novel neuromodulators Front Neuroendocrinol 21 1 56 1:CAS:528: DC%2BD3cXovVaisQ%3D%3D 10.1006/frne.1999.0188 10662535
19. VT Martin M Behbehani 2006 Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis: part 2 Headache 46 365 386 10.1111/j.1526-4610.2006.00370.x 16618254 This review discusses the influence of reproductive events on migraine
20. A Varlibas AK Erdemoglu 2009 Altered trigeminal system excitability in menstrual migraine patients J Headache Pain 10 277 282 10.1007/s10194-009-0132-4 19495932 This study implicates trigeminal excitability in patients with menstrual migraine
21. VT Martin J Lee MM Behbehani 2007 Sensitization of the trigeminal sensory system during different stages of the rat estrous cycle: implications for menstrual migraine Headache 47 552 563 10.1111/j.1526-4610.2006.00685.x 17445105
22. GA Lambert C Donaldson KL Hoskin, et al. 2004 Dilatation induced by 5-HT in the middle meningeal artery of the anaesthetised cat Naunyn Schmiedebergs Arch Pharmacol 369 591 601 1:CAS:528:DC%2BD2cXks1Kmtb0%3D 10.1007/s00210-004- 0935-4 15197536
23. E Shevel 2009 Middle meningeal artery dilatation in migraine Headache 49 1541 1543 10.1111/j.1526-4610.2009.01495.x 19656222
24. M Pecins-Thompson NA Brown SG Kohama CL Bethea 1996 Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques J Neurosci 16 7021 7029 1:CAS:528:DyaK28Xntlegsbg%3D 8824338
25. M Pecins-Thompson NA Brown CL Bethea 1998 Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques Brain Res Mol Brain Res 53 120 129 1:CAS:528:DyaK1cXit1aktr4%3D 10.1016/S0169-328X(97)00286-6 9473622
26. LJ Smith JA Henderson CW Abell CL Bethea 2004 Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques Neuropsychopharmacology 29 2035 2045 1:CAS:528:DC%2BD2cXoslSkur0%3D 10.1038/sj.npp.1300510 15199371
27. EL Sabban S Maharjan R Nostramo, et al. 2010 Divergent effects of estradiol on gene expression of catecholamine biosynthetic enzymes Physiol Behav 99 163 168 1:CAS:528:DC%2BC3cXotl2l 10.1016/j.physbeh.2009.07.011 19638280
28. KY Pau DL Hess S Kohama, et al. 2000 Oestrogen upregulates noradrenaline release in the mediobasal hypothalamus and tyrosine hydroxylase gene expression in the brainstem of ovariectomized rhesus macaques J Neuroendocrinol 12 899 909 1:CAS:528:DC%2BD3cXmsVagtrw%3D 10.1046/j.1365-2826.2000.00549.x 10971815
29. GB Karkanias MA Ansonoff AM Etgen 1996 Estradiol regulation of alpha 1b-adrenoceptor mRNA in female rat hypothalamus-preoptic area J Neuroendocrinol 8 449 455 1:CAS:528:DyaK28XjvFCqt7o%3D 10.1046/j.1365-2826.1996.04716.x 8809675
30. GB Karkanias N Petitti AM Etgen 1995 Progesterone attenuation of alpha 1-adrenergic receptor stimulation of phosphoinositol hydrolysis in hypothalamus of estrogen-primed female rats Endocrinology 136 1993 1999 1:CAS:528: DyaK2MXltFKjtr8%3D 10.1210/en.136.5.1993 7720647
31. PJ Shughrue I Merchenthaler 2000 Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex Front Neuroendocrinol 21 95 101 1:CAS:528:DC%2BD3cXovVaitw%3D%3D 10.1006/frne.1999.0190 10662537
32. CN Epperson K Haga GF Mason, et al. 2002 Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study Arch Gen Psychiatry 59 851 858 1:CAS:528:DC%2BD38Xns1anuro%3D 10.1001/archpsyc.59.9.851 12215085
33. K Eikermann-Haerter E Dileköz C Kudo, et al. 2009 Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1 J Clin Invest 119 99 109 1:CAS:528:DC%2BD1MXmtFChtw%3D%3D 19104150 This animal study provides evidence for an additive effect of gene mutations and steroid hormones in migraine
34. K Eikermann-Haerter MJ Baum MD Ferrari, et al. 2009 Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice Ann Neurol 66 564 568 1:CAS:528:DC%2BD1MXhsVehtrrM 10.1002/ana.21779 19847904
35. MH Herynk SA Fuqua 2004 Estrogen receptor mutations in human disease Endocr Rev 25 869 898 1:CAS:528:DC%2BD2MXjslWnsA%3D%3D 10.1210/er.2003-0010 15583021
36. IU Agoulnik XW Tong DC Fischer, et al. 2004 A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk J Clin Endocrinol Metab 89 6340 6347 1:CAS:528: DC%2BD2cXhtFSit7rK 10.1210/jc.2004-0114 15579801
37. B Cenni D Picard 1999 Ligand-independent activation of steroid receptors: new roles for old players Trends Endocrinol Metab 10 41 46 1:CAS:528: DyaK1MXhvVylt78%3D 10.1016/S1043-2760(98)00121-0 10322393
38. JE Curran RA Lea S Rutherford, et al. 2001 Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer Int J Cancer 95 271 275 1:CAS:528:DC%2BD3MXlt1yqs74%3D 10.1002/1097-0215(20010720)95:4<271::AID-IJC1046>3.0.CO;2-D 11400122
39. NJ Colson RA Lea S Quinlan, et al. 2004 The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups Neurogenetics 5 129 133 1:CAS:528:DC%2BD2cXks1Cisbc%3D 10.1007/s10048-004-0181-4 15133719
40. NJ Colson RA Lea S Quinlan, et al. 2005 Investigation of hormone receptor genes in migraine Neurogenetics 6 17 23 1:CAS:528:DC%2BD2MXhslGnsr8%3D 10.1007/s10048-004-0205-0 15654614
41. K Krithivas SM Yurgalevitch BA Mohr, et al. 1999 Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men J Endocrinol 162 137 142 1:CAS:528: DyaK1MXkvVKqu70%3D 10.1677/joe.0.1620137 10396030
42. CJ Donaldson JP Crapanzano JC Watson, et al. 2002 PROGINS Alu insertion and human genomic diversity Mutat Res 501 137 141 1:CAS:528:DC%2BD38XisV2ksro%3D 11934445
43. SC Schuit FH de Jong L Stolk, et al. 2005 Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women Eur J Endocrinol 153 327 334 1:CAS:528:DC%2BD2MXpslOhsL8%3D 10.1530/eje.1.01973 16061840
44. AM Shearman JA Cooper PJ Kotwinski, et al. 2005 Estrogen receptor alpha gene variation and the risk of stroke Stroke 36 2281 2282 1:CAS:528: DC%2BD2MXhtVeisbnL 10.1161/01.STR.0000181088.76518.ec 16179580
45. NJ Colson RA Lea S Quinlan LR Griffiths 2006 No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility BMC Med Genet 7 12 10.1186/1471-2350-7-12 16504171
46. A Oterino J Pascual 2006 Ruiz de Alegría C, et al.: Association of migraine and ESR1 G325C polymorphism Neuroreport 17 61 64 1:CAS:528: DC%2BD2MXhtlagsLfI 10.1097/01.wnr.0000192735.85287.f4 16361951
47. MA Kaunisto M Kallela E Hämäläinen, et al. 2006 Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura Cephalalgia 26 1462 1472 1:STN:280:DC%2BD28notFGlug%3D%3D 10.1111/j.1468-2982.2006.01228.x 17116097
48. H Lee L Sininger JC Jen, et al. 2007 Association of progesterone receptor with migraine-associated vertigo Neurogenetics 8 195 200 1:CAS:528: DC%2BD2sXnsFaqu70%3D 10.1007/s10048-007-0091-3 17609999
49. • Oterino A, Toriello M, Cayón A, et al.: Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine. Headache 2008, 48:1438-1450. This study provides evidence for genetic interaction between three hormonally related genes.
50. R Corominas M Ribasés E Cuenca-León, et al. 2009 Lack of association of hormone receptor polymorphisms with migraine Eur J Neurol 16 413 415 1:STN:280:DC%2BD1M3nsVelug%3D%3D 10.1111/j.1468-1331.2008.02499.x 19175383
51. G Joshi S Pradhan B Mittal 2010 Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C-∈>∈G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population Cephalalgia 30 311 320
52. Q Yang MJ Khoury J Friedman, et al. 2005 How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol 34 1129 1137 10.1093/ije/dyi130 16043441
53. P Gorroochurn SE Hodge GA Heiman, et al. 2007 Non-replication of association studies: "pseudo-failures" to replicate? Genet Med 9 325 331 10.1097/GIM.0b013e3180676d79 17575498
54. KM Welch JL Brandes NE Berman 2006 Mismatch in how oestrogen modulates molecular and neuronal function may explain menstrual migraine Neurol Sci 27 Suppl 2 S190 S192 10.1007/s10072-006-0599-6 16688628
55. V Puri L Cui CS Liverman, et al. 2005 Ovarian steroids regulate neuropeptides in the trigeminal ganglion Neuropeptides 39 409 417 1:CAS:528:DC%2BD2MXmvVGisbk%3D 10.1016/j.npep.2005.04.002 15936815