Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice

Annals of Neurology

Volumn 66, Issue 4, 2009, Pages 564-568

  Eikermann Haerter, Katharina ^a   Baum, Michael J ^b   Ferrari, Michel D ^c   Van Den Maagdenberg, Arn M J M ^a,c   Moskowitz, Michael A ^a   Ayata, Cenk ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Boston University   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; TESTOSTERONE;

ANDROGEN THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACNA1A GENE; DEPOLARIZATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FAMILIAL HEMIPLEGIC MIGRAINE; GENE; GENE MUTATION; GLIA; MALE; MIGRAINE WITH AURA; MOUSE; MUTANT; NONHUMAN; ORCHIECTOMY; OVARIECTOMY; PHENOTYPE; PRIORITY JOURNAL; SPREADING CORTICAL DEPRESSION;

ANIMALS; CALCIUM CHANNELS; GENE KNOCK-IN TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; MIGRAINE WITH AURA; ORCHIECTOMY; POINT MUTATION; SPREADING CORTICAL DEPRESSION; TESTOSTERONE;

EID: 70449364097     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21779     Document Type: Article

References (30)

1. Thomsen LL, Eriksen MK, Roemer SF, et al. A populationbased study of familial hemiplegic migraine suggests revised diagnostic criteria. Brain 2002;125:1379-1391
2. Ophoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996; 87:543-552.
3. Tottene A, Fellin T, Pagnutti S, et al. Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A 2002;99:13284-13289.
4. van den Maagdenberg AM, Pietrobon D, Pizzorusso T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004;41: 701-710. (Pubitemid 38326833)
5. Tottene A, Conti R, Fabbro A, et al. Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009; 61:762-773.
6. Hadjikhani N, Sanchez Del Rio M, Wu O, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 2001;98:4687-4692. (Pubitemid 32295037)
7. Eikermann-Haerter K, Dilekoz E, Kudo C, et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest 2009;119:99-109.
8. Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002;8:136-142. (Pubitemid 34155124)
9. MacGregor EA. Oestrogen and attacks of migraine with and without aura. Lancet Neurol 2004;3:354-361. (Pubitemid 38648856)
10. Woolley CS, Weiland NG, McEwen BS, Schwartzkroin PA. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci 1997;17: 1848-1859.
11. Rasmussen BK, Jensen R, Schroll M, Olesen J. Epidemiology of headache in a general population - a prevalence study. J Clin Epidemiol 1991;44:1147-1157.
12. Thomsen LL, Kirchmann M, Bjornsson A, et al. The genetic spectrum of a population-based sample of familial hemiplegic migraine. Brain 2007;130:346-356. (Pubitemid 46181089)
13. Brennan KC, Romero Reyes M, Lopez Valdes HE, et al. Reduced threshold for cortical spreading depression in female mice. Ann Neurol 2007;61:603-606.
14. Moehlig RC. Methyl testosterone for migraine of women; report of sixty cases. J Mich State Med Soc 1955;54:577-579; passim.
15. Calton GJ, Burnett JW. Danazol and migraine. N Engl J Med 1984;310:721-722.
16. Jonsson B, Von Reis G, Sahlgren E. [Testosterone therapy of headache.]. Acta Psychiatr Neurol Scand Suppl 1951;74: 102-105.
17. Nelson JF, Latham KR, Finch CE. Plasma testosterone levels in C57BL/6J male mice: effects of age and disease. Acta Endocrinol (Copenh) 1975;80:744-752.
18. Lichten EM, Bennett RS, Whitty AJ, Daoud Y. Efficacy of danazol in the control of hormonal migraine. J Reprod Med 1991;36:419-424.
19. Vincent FM. Migraine responsive to danazol. Neurology 1985; 35:618.
20. Thakur MK, Sharma PK. Transcription of estrogen receptor alpha and beta in mouse cerebral cortex: effect of age, sex, 17beta-estradiol and testosterone. Neurochem Int 2007;50: 314-321.
21. Smith SS. Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect. Brain Res 1989; 503:354-357.
22. Sato K, Matsuki N, Ohno Y, Nakazawa K. Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha. J Neurochem 2003;86:1498-1505. (Pubitemid 37174266)
23. Arango O, Bielsa O, Pascual-Calvet J, et al. [Disappearance of migraine crises in two patients with male infertility treated with human chorionic gonadotropin/human menopausal gonadotrophin]. Rev Neurol 1996;24:977-979.
24. Pringsheim T, Gooren L. Migraine prevalence in male to female transsexuals on hormone therapy. Neurology 2004;63: 593-594. (Pubitemid 39031411)
25. Nudler SI, Pagani MR, Urbano FJ, et al. Testosterone modulates Ca(v2.2) calcium channels' functional expression at rat levator ani neuromuscular junction. Neuroscience 2005;134: 817-826.
26. Pouliot WA, Handa RJ, Beck SG. Androgen modulates N-methyl-D-aspartate- mediated depolarization in CA1 hippocampal pyramidal cells. Synapse 1996;23:10-19. (Pubitemid 26138643)
27. Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol 2006;5:148-157.
28. Herzog AG, Seibel MM, Schomer DL, et al. Reproductive endocrine disorders in men with partial seizures of temporal lobe origin. Arch Neurol 1986;43:347-350. (Pubitemid 16106952)
29. Reddy DS. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17betaestradiol. Neuroscience 2004;129:195-207.
30. Kudo C, Nozari A, Moskowitz MA, Ayata C. The impact of anesthetics and hyperoxia on cortical spreading depression. Exp Neurol 2008;212:201-206.