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Volumn 207, Issue 1, 2010, Pages 27-34

Peripubertal aromatase inhibition in male rats has adverse long-term effects on bone strength and growth and induces prostatic hyperplasia

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; LETROZOLE; SOMATOMEDIN C; AROMATASE INHIBITOR; LUTEINIZING HORMONE; NITRILE; TRIAZOLE DERIVATIVE;

EID: 77957121856     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-10-0006     Document Type: Article
Times cited : (17)

References (34)
  • 1
    • 0032572929 scopus 로고    scopus 로고
    • Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency
    • doi:10.1056/NEJM199808273390905
    • Bilezikian JP, Morishima A, Bell J & Grumbach MM 1998 Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. New England Journal of Medicine 339 599-603. (doi:10.1056/NEJM199808273390905)
    • (1998) New England Journal of Medicine , vol.339 , pp. 599-603
    • Bilezikian, J.P.1    Morishima, A.2    Bell, J.3    Grumbach, M.M.4
  • 3
    • 58549105919 scopus 로고    scopus 로고
    • Update on the role of aromatase inhibitors in growth disorders
    • doi:10.1159/000178040
    • Dunkel L 2009 Update on the role of aromatase inhibitors in growth disorders. Hormone Research 71 (Supplement 1) 57-63. (doi:10.1159/000178040)
    • (2009) Hormone Research , vol.71 , Issue.SUPPL. 1 , pp. 57-63
    • Dunkel, L.1
  • 4
    • 4043127520 scopus 로고    scopus 로고
    • The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice
    • DOI 10.1677/joe.0.1820165
    • Eshet R, Maor G, Ben Ari T, Ben Eliezer M, Gat-Yablonski G & Phillip M 2004 The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice. Journal of Endocrinology 182 165-172. (doi:10.1677/joe.0.1820165) (Pubitemid 39076912)
    • (2004) Journal of Endocrinology , vol.182 , Issue.1 , pp. 165-172
    • Eshet, R.1    Maor, G.2    Ari, T.B.3    Eliezer, M.B.4    Gat-Yablonski, G.5    Phillip, M.6
  • 5
    • 12344298592 scopus 로고    scopus 로고
    • Role of estrogens in development of prostate cancer
    • doi:10.1016/j.jsbmb.2004.10.016
    • Harkonen P & Makela S 2004 Role of estrogens in development of prostate cancer. Journal of Steroid Biochemistry and Molecular Biology 92 297-305. (doi:10.1016/j.jsbmb.2004.10.016)
    • (2004) Journal of Steroid Biochemistry and Molecular Biology , vol.92 , pp. 297-305
    • Harkonen, P.1    Makela, S.2
  • 6
    • 28744459484 scopus 로고    scopus 로고
    • Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: A randomized controlled trial
    • doi:10.1210/jc.2005-1392
    • Hero M, Norjavaara E & Dunkel L 2005 Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial. Journal of Clinical Endocrinology and Metabolism 90 6396-6402. (doi:10.1210/jc.2005-1392)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 6396-6402
    • Hero, M.1    Norjavaara, E.2    Dunkel, L.3
  • 7
    • 33749046077 scopus 로고    scopus 로고
    • Blockade of oestrogen biosynthesis in peripubertal boys: Effects on lipid metabolism, insulin sensitivity, and body composition
    • doi:10.1530/eje.1.02226
    • Hero M, Ankarberg-Lindgren C, Taskinen MR & Dunkel L 2006a Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition. European Journal of Endocrinology 155 453-460. (doi:10.1530/eje.1.02226)
    • (2006) European Journal of Endocrinology , vol.155 , pp. 453-460
    • Hero, M.1    Ankarberg-Lindgren, C.2    Taskinen, M.R.3    Dunkel, L.4
  • 8
    • 33645982874 scopus 로고    scopus 로고
    • Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty
    • doi:10.1111/j.1365-2265.2006.02499.x
    • Hero M, Wickman S & Dunkel L 2006b Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty. Clinical Endocrinology 64 510-513. (doi:10.1111/j.1365-2265.2006.02499.x)
    • (2006) Clinical Endocrinology , vol.64 , pp. 510-513
    • Hero, M.1    Wickman, S.2    Dunkel, L.3
  • 9
    • 63349110946 scopus 로고    scopus 로고
    • Impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in pre- And peripubertal boys with idiopathic short stature
    • doi:10.1159/000208803
    • Hero M, Makitie O, Kroger H, Nousiainen E, Toiviainen-Salo S & Dunkel L 2009 Impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in pre- and peripubertal boys with idiopathic short stature. Hormone Research 71 290-297. (doi:10.1159/000208803)
    • (2009) Hormone Research , vol.71 , pp. 290-297
    • Hero, M.1    Makitie, O.2    Kroger, H.3    Nousiainen, E.4    Toiviainen-Salo, S.5    Dunkel, L.6
  • 11
    • 35348948901 scopus 로고    scopus 로고
    • Effects of aromatase inhibitors letrozole and anastrazole on bone metabolism and steroid hormone levels in intact female rats
    • DOI 10.1080/09513590701557119, PII 783196446
    • Kumru S, Yildiz AA, Yilmaz B, Sandal S & Gurates B 2007 Effects of aromatase inhibitors letrozole and anastrazole on bone metabolism and steroid hormone levels in intact female rats. Gynecological Endocrinology 23 556-561. (doi:10.1080/09513590701557119) (Pubitemid 47613729)
    • (2007) Gynecological Endocrinology , vol.23 , Issue.10 , pp. 556-561
    • Kumru, S.1    Yildiz, A.A.2    Yilmaz, B.3    Sandal, S.4    Gurates, B.5
  • 12
    • 34547138420 scopus 로고    scopus 로고
    • A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovarian syndrome
    • doi:10.1210/en.2007-0168
    • Manneras L, Cajander S, Holmang A, Seleskovic Z, Lystig T, Lonn M & Stener-Victorin E 2007 A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovarian syndrome. Endocrinology 148 3781-3791. (doi:10.1210/en.2007-0168)
    • (2007) Endocrinology , vol.148 , pp. 3781-3791
    • Manneras, L.1    Cajander, S.2    Holmang, A.3    Seleskovic, Z.4    Lystig, T.5    Lonn, M.6    Stener-Victorin, E.7
  • 13
    • 11044233901 scopus 로고    scopus 로고
    • An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys
    • Mauras N, Welch S, Rini A & Klein KO 2004 An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys. Journal of Pediatric Endocrinology and Metabolism 17 1597-1606.
    • (2004) Journal of Pediatric Endocrinology and Metabolism , vol.17 , pp. 1597-1606
    • Mauras, N.1    Welch, S.2    Rini, A.3    Klein, K.O.4
  • 14
    • 22244493958 scopus 로고    scopus 로고
    • Sperm analysis in growth hormone-deficient adolescents previously treated with an aromatase inhibitor: Comparison with normal controls
    • DOI 10.1016/j.fertnstert.2005.02.012, PII S0015028205005649
    • Mauras N, Bell J, Snow BG & Winslow KL 2005 Sperm analysis in growth hormone-deficient adolescents previously treated with an aromatase inhibitor: comparison with normal controls. Fertility and Sterility 84 239-242. (doi:10.1016/j.fertnstert.2005.02.012) (Pubitemid 40991490)
    • (2005) Fertility and Sterility , vol.84 , Issue.1 , pp. 239-242
    • Mauras, N.1    Bell, J.2    Snow, B.G.3    Winslow, K.L.4
  • 16
    • 0035015891 scopus 로고    scopus 로고
    • Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland
    • doi:10.1210/en.142.6.2458
    • McPherson SJ, Wang H, Jones ME, Pedersen J, Iismaa TP, Wreford N, Simpson ER & Risbridger GP 2001 Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142 2458-2467. (doi:10.1210/en.142.6.2458)
    • (2001) Endocrinology , vol.142 , pp. 2458-2467
    • McPherson, S.J.1    Wang, H.2    Jones, M.E.3    Pedersen, J.4    Iismaa, T.P.5    Wreford, N.6    Simpson, E.R.7    Risbridger, G.P.8
  • 17
    • 47749096762 scopus 로고    scopus 로고
    • Estrogen-regulated development and differentiation of the prostate
    • doi:10.1111/j.1432-0436.2008.00291.x
    • McPherson SJ, Ellem SJ & Risbridger GP 2008 Estrogen-regulated development and differentiation of the prostate. Differentiation 76 660-670. (doi:10.1111/j.1432-0436.2008.00291.x)
    • (2008) Differentiation , vol.76 , pp. 660-670
    • McPherson, S.J.1    Ellem, S.J.2    Risbridger, G.P.3
  • 18
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • doi:10.1210/jc.80.12.3689
    • Morishima A, Grumbach MM, Simpson ER, Fisher C & Qin K 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. Journal of Clinical Endocrinology and Metabolism 80 3689-3698. (doi:10.1210/jc.80.12.3689)
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 3689-3698
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 19
    • 0037205899 scopus 로고    scopus 로고
    • Effect of estrogen deficiency in the male: The ArKO mouse model
    • DOI 10.1016/S0303-7207(02)00090-4, PII S0303720702000904
    • Murata Y, Robertson KM, Jones ME & Simpson ER 2002 Effect of estrogen deficiency in the male: the ArKO mouse model. Molecular and Cellular Endocrinology 193 7-12. (doi:10.1016/S0303-7207(02)00090-4) (Pubitemid 34823602)
    • (2002) Molecular and Cellular Endocrinology , vol.193 , Issue.1-2 , pp. 7-12
    • Murata, Y.1    Robertson, K.M.2    Jones, M.E.E.3    Simpson, E.R.4
  • 20
    • 33645227658 scopus 로고    scopus 로고
    • The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity
    • doi:10.1677/joe.1.06508
    • Nolan LA & Levy A 2006 The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity. Journal of Endocrinology 188 387-396. (doi:10.1677/joe.1.06508)
    • (2006) Journal of Endocrinology , vol.188 , pp. 387-396
    • Nolan, L.A.1    Levy, A.2
  • 21
    • 0028080879 scopus 로고
    • Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle
    • doi:10.1210/en.135.6.2608
    • O'Donnell L, McLachlan RI, Wreford NG & Robertson DM 1994 Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle. Endocrinology 135 2608-2614. (doi:10.1210/en.135.6.2608)
    • (1994) Endocrinology , vol.135 , pp. 2608-2614
    • O'Donnell, L.1    McLachlan, R.I.2    Wreford, N.G.3    Robertson, D.M.4
  • 23
    • 33847790692 scopus 로고    scopus 로고
    • The role of estrogens in normal and abnormal development of the prostate gland
    • DOI 10.1196/annals.1386.009, Estrogens and Human Diseases
    • Prins GS, Huang L, Birch L & Pu Y 2006 The role of estrogens in normal and abnormal development of the prostate gland. Annals of the New York Academy of Sciences 1089 1-13. (doi:10.1196/annals.1386.009) (Pubitemid 47092064)
    • (2006) Annals of the New York Academy of Sciences , vol.1089 , pp. 1-13
    • Prins, G.S.1    Huang, L.2    Birch, L.3    Pu, Y.4
  • 24
    • 34247134018 scopus 로고    scopus 로고
    • Developmental estrogen exposures predispose to prostate carcinogenesis with aging
    • DOI 10.1016/j.reprotox.2006.10.001, PII S0890623806002620
    • Prins GS, Birch L, Tang WY & Ho SM 2007 Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reproductive Toxicology 23 374-382. (doi:10.1016/j.reprotox.2006.10.001) (Pubitemid 46602925)
    • (2007) Reproductive Toxicology , vol.23 , Issue.3 , pp. 374-382
    • Prins, G.S.1    Birch, L.2    Tang, W.-Y.3    Ho, S.-M.4
  • 26
    • 42949151943 scopus 로고    scopus 로고
    • Use of aromatase inhibitors in children and adolescents with disorders of growth and adolescent development
    • doi:10.1542/peds.2007-2081
    • Shulman DI, Francis GL, Palmert MR & Eugster EA 2008 Use of aromatase inhibitors in children and adolescents with disorders of growth and adolescent development. Pediatrics 121 e975-e983. (doi:10.1542/peds.2007-2081)
    • (2008) Pediatrics , vol.121
    • Shulman, D.I.1    Francis, G.L.2    Palmert, M.R.3    Eugster, E.A.4
  • 28
    • 0037291609 scopus 로고    scopus 로고
    • Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency
    • DOI 10.1677/joe.0.1760237
    • Takeda K, Toda K, Saibara T, Nakagawa M, Saika K, Onishi T, Sugiura T & Shizuta Y 2003 Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency. Journal of Endocrinology 176 237-246. (doi:10.1677/joe.0.1760237) (Pubitemid 36284816)
    • (2003) Journal of Endocrinology , vol.176 , Issue.2 , pp. 237-246
    • Takeda, K.1    Toda, K.2    Saibara, T.3    Nakagawa, M.4    Saika, K.5    Onishi, T.6    Sugiura, T.7    Shizuta, Y.8
  • 29
    • 0034048347 scopus 로고    scopus 로고
    • Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility
    • Turner KJ, Morley M, Atanassova N, Swanston ID & Sharpe RM 2000 Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility. Journal of Endocrinology 164 225-238. (doi:10.1677/joe.0.1640225) (Pubitemid 30114670)
    • (2000) Journal of Endocrinology , vol.164 , Issue.2 , pp. 225-238
    • Turner, K.J.1    Morley, M.2    Atanassova, N.3    Swanston, I.D.4    Sharpe, R.M.5
  • 30
    • 0030958817 scopus 로고    scopus 로고
    • Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats
    • DOI 10.1210/en.138.6.2301
    • Vanderschueren D, van Herck E, Nijs J, Ederveen AG, De Coster R & Bouillon R 1997 Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 138 2301-2307. (doi:10.1210/en.138.6.2301) (Pubitemid 27215229)
    • (1997) Endocrinology , vol.138 , Issue.6 , pp. 2301-2307
    • Vanderschueren, D.1    Van Herck, E.2    Nijs, J.3    Ederveen, A.G.H.4    De Coster, R.5    Bouillon, R.6
  • 32
    • 33645329097 scopus 로고    scopus 로고
    • Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: A study in the androgen receptor knockout mouse model
    • doi:10.1359/jbmr.060103
    • Venken K, De Gendt K, Boonen S, Ophoff J, Bouillon R, Swinnen JV, Verhoeven G & Vanderschueren D 2006 Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model. Journal of Bone and Mineral Research 21 576-585. (doi:10.1359/jbmr.060103)
    • (2006) Journal of Bone and Mineral Research , vol.21 , pp. 576-585
    • Venken, K.1    De Gendt, K.2    Boonen, S.3    Ophoff, J.4    Bouillon, R.5    Swinnen, J.V.6    Verhoeven, G.7    Vanderschueren, D.8
  • 33
    • 0035796007 scopus 로고    scopus 로고
    • A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: A randomised controlled trial
    • DOI 10.1016/S0140-6736(00)04895-9
    • Wickman S, Sipila I, Ankarberg-Lindgren C, Norjavaara E & Dunkel L 2001 A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. Lancet 357 1743-1748. (doi:10.1016/S0140-6736(00)04895-9) (Pubitemid 32524203)
    • (2001) Lancet , vol.357 , Issue.9270 , pp. 1743-1748
    • Wickman, S.1    Sipila, I.2    Ankarberg-Lindgren, C.3    Norjavaara, E.4    Dunkel, L.5
  • 34
    • 0042885372 scopus 로고    scopus 로고
    • Effects of suppression of estrogen action by the p450 aromatase inhibitor letrozole on bone mineral density and bone turnover in pubertal boys
    • doi:10.1210/jc.2002-021643
    • Wickman S, Kajantie E & Dunkel L 2003 Effects of suppression of estrogen action by the p450 aromatase inhibitor letrozole on bone mineral density and bone turnover in pubertal boys. Journal of Clinical Endocrinology and Metabolism 88 3785-3793. (doi:10.1210/jc.2002-021643)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , pp. 3785-3793
    • Wickman, S.1    Kajantie, E.2    Dunkel, L.3


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