A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl4-cirrhotic liver

Liver International

Volumn 30, Issue 7, 2010, Pages 988-994

  Zipprich, Alexander ^a,b   Mehal, Wajahat Z ^a   Ripoll, Cristina ^a,b   Groszmann, Roberto J ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Adenosine; Cirrhosis; Hepatic artery; Liver perfusion

Indexed keywords

ADENOSINE A1 RECEPTOR; CAFFEINE; CARBON TETRACHLORIDE; METHOXAMINE; N(G) METHYLARGININE; NITRIC OXIDE; 8-(4-SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ENZYME INHIBITOR; NITRIC OXIDE SYNTHASE; THEOPHYLLINE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ARTERY RESISTANCE; ARTICLE; DOSE RESPONSE; HEPATIC ARTERY; LIVER CIRRHOSIS; LIVER PERFUSION; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; VASCULAR RESISTANCE; VASODILATATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; EXPERIMENTAL LIVER CIRRHOSIS; METABOLISM; PATHOPHYSIOLOGY; PERFUSION; PORTAL VEIN;

ADENOSINE; ANIMALS; BLOTTING, WESTERN; CAFFEINE; CARBON TETRACHLORIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEPATIC ARTERY; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PERFUSION; PORTAL VEIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; THEOPHYLLINE; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS; ADENOSINE A1 RECEPTOR ANTAGONISTS;

EID: 77957120828     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02278.x     Document Type: Article

References (25)

1. Lautt WW, Legare DJ, Ezzat WR. Quantitation of the hepatic arterial buffer response to graded changes in portal blood flow. Gastroenterology 1990, 98:1024-8.
2. Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol 1985, 249:G549-56.
3. Lautt WW, Legare DJ, d'Almeida MS. Adenosine as putative regulator of hepatic arterial flow (the buffer response). Am J Physiol 1985, 248:H331-8.
4. Mathie RT, Alexander B. The role of adenosine in the hyperaemic response of the hepatic artery to portal vein occlusion (the 'buffer response'). Br J Pharmacol 1990, 100:626-30.
5. Tabrizchi R, Bedi S. Pharmacology of adenosine receptors in the vasculature. Pharmacol Ther 2001, 91:133-47.
6. Mathie RT, Alexander B, Ralevic V, Burnstock G. Adenosine-induced dilatation of the rabbit hepatic arterial bed is mediated by A2-purinoceptors. Br J Pharmacol 1991, 103:1103-7.
7. Zipprich A, Loureiro-Silva MR, D'Silva I, Groszmann RJ. The role of hepatic arterial flow on portal venous and hepatic venous wedged pressure in the isolated perfused CCl4-cirrhotic liver. Am J Physiol Gastrointest Liver Physiol 2008, 295:G197-202.
8. Zipprich A, Loureiro-Silva MR, Jain D, D'Silva I, Groszmann RJ. Nitric oxide and vascular remodeling modulate hepatic arterial vascular resistance in the isolated perfused cirrhotic rat liver. J Hepatol 2008, 49:739-45.
9. Richter S, Mucke I, Menger MD, Vollmar B. Impact of intrinsic blood flow regulation in cirrhosis: maintenance of hepatic arterial buffer response. Am J Physiol Gastrointest Liver Physiol 2000, 279:G454-62.
10. Mucke I, Richter S, Menger MD, Vollmar B. Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers. Int J Colorectal Dis 2000, 15:335-41.
11. Kleber G, Steudel N, Behrmann C. Hepatic arterial flow volume and reserve in patients with cirrhosis: use of intra-arterial Doppler and adenosine infusion. Gastroenterology 1999, 116:906-14.
12. Bryan PT, Marshall JM. Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia. J Physiol 1999, 514((Part 1)):163-75.
13. Frobert O, Haink G, Simonsen U. Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation. J Physiol 2006, 570:375-84.
14. Gardemann A, Strulik H, Jungermann K. A portal-arterial glucose concentration gradient as a signal for an insulin-dependent net glucose uptake in perfused rat liver. FEBS Lett 1986, 202:255-9.
15. Hamilton RL, Berry MN, Williams MC, Severinghaus EM. A simple and inexpensive membrane " lung" for small organ perfusion. J Lipid Res 1974, 15:182-6.
16. Takasaki S, Hano H. Three-dimensional observations of the human hepatic artery (arterial system in the liver). J Hepatol 2001, 34:455-66.
17. Richter S, Vollmar B, Mucke I, Post S, Menger MD. Hepatic arteriolo-portal venular shunting guarantees maintenance of nutritional microvascular supply in hepatic arterial buffer response of rat livers. J Physiol 2001, 531:193-201.
18. Macedo MP, Lautt WW. Potentiation to vasodilators by nitric oxide synthase blockade in superior mesenteric but not hepatic artery. Am J Physiol 1997, 272:G507-14.
19. Fahim M, Hussain T, Mustafa SJ. Role of endothelium in adenosine receptor-mediated vasorelaxation in hypertensive rats. Fundam Clin Pharmacol 2001, 15:325-34.
20. Morimoto Y, Wettstein M, Haussinger D. Hepatocyte heterogeneity in response to extracellular adenosine. Biochem J 1993, 293((Part 2)):573-81.
21. Bryan PT, Marshall JM. Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. J Physiol 1999, 514((Pt 1)):151-62.
22. Moreau R, Lee SS, Soupison T, Roche-Sicot J, Sicot C. Abnormal tissue oxygenation in patients with cirrhosis and liver failure. J Hepatol 1988, 7:98-105.
23. Colle I, Langlet P, Barriere E. Evolution of hypoxemia in patients with severe cirrhosis. J Gastroenterol Hepatol 2002, 17:1106-9.
24. Moller S, Hillingso J, Christensen E, Henriksen JH. Arterial hypoxaemia in cirrhosis: fact or fiction? Gut 1998, 42:868-74.
25. Zipprich A, Steudel N, Behrmann C. Functional significance of hepatic arterial flow reserve in patients with cirrhosis. Hepatology 2003, 37:385-92.