Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation

European Journal of Endocrinology

Volumn 163, Issue 4, 2010, Pages 609-616

  Diz Lois, Maria Teresa ^a   Garcia Buela, Jesús ^a   Suarez, Francisco ^a   Sangiao Alvarellos, Susana ^a,b   Vidal, Ovidio ^a   Cordido, Fernando ^a,b  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIVER CIRRHOSIS; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; BLOOD; GLUCOSE TOLERANCE TEST; MIDDLE AGED; PHYSIOLOGY; POSTPRANDIAL STATE; YOUNG ADULT;

ADULT; AGED; FASTING; FEMALE; GHRELIN; GLUCOSE TOLERANCE TEST; HUMANS; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; YOUNG ADULT;

EID: 77957107899     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-10-0508     Document Type: Article

References (48)

1. Selberg O, Bottcher J, Tusch G, Pichlmayr R, Henkel E & Muller MJ. Identification of high- and low-risk patients before liver transplantation: a prospective cohort study of nutritional and metabolic parameters in 150 patients. Hepatology 1997 25 652-657. (doi:10.1002/hep.510250327)
2. Matos C, Porayko MK, Francisco-Ziller N & DiCecco S. Nutrition and chronic liver disease. Journal of Clinical Gastroenterology 2002 35 391-397. (doi:10.1097/00004836-200211000-00007)
3. Lautz HU, Selberg O, Korber J, Burger M & Muller MJ. Proteincalorie malnutrition in liver cirrhosis. Clinical Investigator 1992 70 478-486.
4. Merli M, Riggio O, Dally L & PINC (Policentrica Italiana Nutrizione Cirrosi). Does malnutrition affect survival in cirrhosis? Hepatology 1996 23 1041-1046. (doi:10.1002/hep.510230516)
5. Cordido F, Penalva A, Dieguez C & Casanueva FF. Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity. Journal of Clinical Endocrinology and Metabolism 1993 76 819-823. (doi:10.1210/jc.76.4.819)
6. Alvarez-Castro P, Isidro ML, Garcia-Buela J, Leal-Cerro A, Broglio F, Tassone F, Ghigo E, Dieguez C, Casanueva FF & Cordido F. Marked GH secretion after ghrelin alone or combined with GH-releasing hormone (GHRH) in obese patients. Clinical Endocrinology 2004 61 250-255. (doi:10.1111/j.1365-2265.2004. 02092.x)
7. van der Lely AJ, Tschop M, Heiman ML & Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Reviews 2004 25 426-457. (doi:10.1210/er.2002-0029) (Pubitemid 38780667)
8. Tschop M, Smiley DL & Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000 407 908-913. (doi:10.1038/35038090)
9. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA & Bloom SR. Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism 2001 86 5992. (doi:10.1210/jc.86.12.5992)
10. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP & Purnell JQ. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New England Journal of Medicine 2002 346 1623-1630. (doi:10.1056/NEJMoa012908)
11. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E & Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001 50 707-709. (doi:10.2337/diabetes.50.4.707)
12. Muccioli G, Tschop M, Papotti M, Deghenghi R, Heiman M & Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. European Journal of Pharmacology 2002 440 235-254. (doi:10.1016/S0014-2999(02)01432-2) (Pubitemid 34458027)
13. Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, Heiman ML, Lehnert P, Fichter M & Tschop M. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. European Journal of Endocrinology 2001 145 669-673. (doi:10.1530/eje.0.1450669)
14. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K & Matsukura S. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. Journal of Clinical Endocrinology and Metabolism 2002 87 240-244. (doi:10.1210/jc.87.1.240)
15. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE & Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001 50 1714-1719. (doi:10.2337/diabetes.50.8.1714) (Pubitemid 33641587)
16. Kojima M & Kangawa K. Ghrelin: structure and function. Physiological Reviews 2005 85 495-522. (doi:10.1152/physrev.00012.2004)
17. Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N & Takano K. Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. Journal of Clinical Endocrinology and Metabolism 2004 89 5707-5712. (doi:10.1210/jc.2004-0353)
18. Marchesini G, Bianchi G, Lucidi P, Villanova N, Zoli M & De Feo P. Plasma ghrelin concentrations, food intake, and anorexia in liver failure. Journal of Clinical Endocrinology and Metabolism 2004 89 2136-2141. (doi:10.1210/jc.2003-031771)
19. Kalaitzakis E, Bosaeus I, Ohman L & Bjornsson E. Altered postprandial glucose, insulin, leptin, and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditure. American Journal of Clinical Nutrition 2007 85 808-815. (Pubitemid 46393514)
20. Ataseven H, Bahcecioglu IH, Kuzu N, Yalniz M, Celebi S, Erensoy A & Ustundag B. The levels of ghrelin, leptin, TNF-alpha, and IL-6 in liver cirrhosis and hepatocellular carcinoma due to HBV and HDV infection. Mediators of Inflammation 2006 2006 78380. (doi:10.1155/MI/2006/78380)
21. Takahashi H, Kato A, Onodera K & Suzuki K. Fasting plasma ghrelin levels reflect malnutrition state in patients with liver cirrhosis. Hepatology Research 2006 34 117-123. (doi:10.1016/j.hepres.2005.03.019)
22. Breidert M, Zimmermann TF, Schneider R, Ehninger G & Brabant G. Ghrelin/leptin-imbalance in patients with primary biliary cirrhosis. Experimental and Clinical Endocrinology and Diabetes 2004 112 123-126. (doi:10.1055/s-2004-817819) (Pubitemid 38445490)
23. Tacke F, Brabant G, Kruck E, Horn R, Schoffski P, Hecker H, Manns MP & Trautwein C. Ghrelin in chronic liver disease. Journal of Hepatology 2003 38 447-454. (doi:10.1016/S0168-8278(02)00438-5)
24. Diz-Lois MT, Garcia-Buela J, Suarez F, Sangiao-Alvarellos S, Vidal O & Cordido F. Fasting and postprandial plasma ghrelin levels are decreased in patients with liver failure previous to liver transplantation. Endocrine 2009 35 467-476. (doi:10.1007/s12020-009-9170-6)
25. Granado M, Martin AI, Lopez-Menduina M, Lopez-Calderon A & Villanua MA. GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia. American Journal of Physiology. Endocrinology and Metabolism 2008 294 E131-E141. (doi:10.1152/ajpendo.00308.2007)
26. Iseri SO, Sener G, Saglam B, Ercan F, Gedik N & Yegen BC. Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats. Regulatory Peptides 2008 146 73-79. (doi:10.1016/j.regpep.2007.08.014)
27. Kasimay O, Iseri SO, Barlas A, Bangir D, Yegen C, Arbak S & Yegen BC. Ghrelin ameliorates pancreaticobiliary inflammation and associated remote organ injury in rats. Hepatology Research 2006 36 11-19. (doi:10.1016/j.hepres.2006. 06.009)
28. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 412-419. (doi:10.1007/BF00280883)
29. Marchesini G, Pagotto U, Bugianesi E, De Iasio R, Manini R, Vanni E, Pasquali R, Melchionda N & Rizzetto M. Low ghrelin concentrations in nonalcoholic fatty liver disease are related to insulin resistance. Journal of Clinical Endocrinology and Metabolism 2003 88 5674-5679. (doi:10.1210/jc.2003- 031094)
30. Haqq AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH & Purnell JQ. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. Journal of Clinical Endocrinology and Metabolism 2003 88 174-178. (doi:10.1210/jc.2002-021052)
31. Murdolo G, Lucidi P, Di Loreto C, Parlanti N, De Cicco A, Fatone C, Fanelli CG, Bolli GB, Santeusanio F & De Feo P. Insulin is required for prandial ghrelin suppression in humans. Diabetes 2003 52 2923-2927. (doi:10.2337/diabetes.52.12.2923)
32. Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV & Sherwin RS. The influence of insulin on circulating ghrelin. American Journal of Physiology. Endocrinology and Metabolism 2003 284 E313-E316.
33. Blom WA, Stafleu A, de Graaf C, Kok FJ, Schaafsma G & Hendriks HF. Ghrelin response to carbohydrate-enriched breakfast is related to insulin. American Journal of Clinical Nutrition 2005 81 367-375. (Pubitemid 43073337)
34. Caixas A, Bashore C, Nash W, Pi-Sunyer F & Laferrere B. Insulin, unlike food intake, does not suppress ghrelin in human subjects. Journal of Clinical Endocrinology and Metabolism 2002 87 1902. (doi:10.1210/jc.87.4.1902)
35. Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M & Luger A. Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo-controlled crossover clamp study. Diabetes 2003 52 16-20. (doi:10.2337/diabetes.52.1.16)
36. Nass R, Farhy LS, Liu J, Prudom CE, Johnson ML, Veldhuis P, Pezzoli SS, Oliveri MC, Gaylinn BD, Geysen HM & Thorner MO. Evidence for acyl-ghrelin modulation of growth hormone release in the fed state. Journal of Clinical Endocrinology and Metabolism 2008 93 1988-1994. (doi:10.1210/jc.2007-2234)
37. van der Toorn FM, Janssen JA, de Herder WW, Broglio F, Ghigo E & van der Lely AJ. Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly. European Journal of Endocrinology 2002 147 195-199. (doi:10.1530/eje.0.1470195)
38. Barkan AL, Dimaraki EV, Jessup SK, Symons KV, Ermolenko M & Jaffe CA. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. Journal of Clinical Endocrinology and Metabolism 2003882180-2184. (doi:10.1210/jc.2002-021169)
39. Jarkovska Z, Rosicka M, Marek J, Hana V, Weiss V, Justova V, Lacinova Z, Haluzik M & Krsek M. Plasma levels of total and active ghrelin in acromegaly and growth hormone deficiency. Physiological Research 2006 55 175-181.
40. Isidro ML, Nemina R, Garcia-Buela J, Sangiao-Alvarellos S & Cordido F. Effect of oral glucose on acylated and total ghrelin secretion in acromegalic patients. Neuro Endocrinology Letters 2007 28 596-603.
41. Cappiello V, Ronchi C, Morpurgo PS, Epaminonda P, Arosio M, Beck-Peccoz P & Spada A. Circulating ghrelin levels in basal conditions and during glucose tolerance test in acromegalic patients. European Journal of Endocrinology 2002 147 189-194. (doi:10.1530/eje.0.1470189)
42. Freda PU, Reyes CM, Conwell IM, Sundeen RE & Wardlaw SL. Serum ghrelin levels in acromegaly: effects of surgical and long-acting octreotide therapy. Journal of Clinical Endocrinology and Metabolism 2003 88 2037-2044. (doi:10.1210/jc.2002-021683)
43. Kozakowski J, Rabijewski M & Zgliczynski W. Decrease in serum ghrelin levels in patients with acromegaly normalize after successful surgical treatment. Endokrynologia Polska 2005 56 862-870.
44. Vestergaard ET, Dall R, Lange KH, Kjaer M, Christiansen JS & Jorgensen JO. The ghrelin response to exercise before and after growth hormone administration. Journal of Clinical Endocrinology and Metabolism 2007 92 297-303. (doi:10.1210/jc.2006-1435) (Pubitemid 46067547)
45. Otto B, Tschop M, Heldwein W, Pfeiffer AF & Diederich S. Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. European Journal of Endocrinology 2004 151 113-117. (doi:10.1530/eje.0.1510113)
46. Badaoui A, De Saeger C, Duchemin J, Gihousse D, de Timary P & Starkel P. Alcohol dependence is associated with reduced plasma and fundic ghrelin levels. European Journal of Clinical Investigation 2008 38 397-403. (doi:10.1111/j.1365-2362.2008.01947.x)
47. Moreno M, Chaves JF, Sancho-Bru P, Ramalho F, Ramalho LN, Mansego ML, Ivorra C, Dominguez M, Conde L, Millan C, Mari M, Colmenero J, Lozano JJ, Jares P, Vidal J, Forns X, Arroyo V, Caballeria J, Gines P & Bataller R. Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology 2010 51 974-985. (doi:10.1002/hep.23421)
48. Kalaitzakis E, Sadik R, Holst JJ, Ohman L & Bjornsson E. Gut transit is associated with gastrointestinal symptoms and gut hormone profile in patients with cirrhosis. Clinical Gastroenterology and Hepatology 2009 7 346-352. (doi:10.1016/j.cgh.2008.11.022)