Variation in colonization, ADP-ribosylating and vacuolating cytotoxin, and pulmonary disease severity among Mycoplasma pneumoniae strains

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 6, 2010, Pages 797-804

  Techasaensiri, Chonnamet ^a   Tagliabue, Claudia ^b   Cagle, Marianna ^c   Iranpour, Pooya ^a   Katz, Kathy ^c   Kannan, Thirumalai R ^c   Coalson, Jacqueline J ^c   Baseman, Joel B ^c   Hardy, R Doug ^d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Divisions of Adult and Pediatric Infectious Diseases   (United States)

Author keywords

ADP ribosylating; Asthma; Mycoplasma pneumoniae; Pneumonia; Toxin

Indexed keywords

ADENOSINE DIPHOSPHATE; CHEMOKINE; CYTOKINE; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 5; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; VACUOLATING TOXIN; BACTERIAL PROTEIN; BACTERIAL TOXIN; CARDS TOXIN, MYCOPLASMA PNEUMONIAE; CYTOTOXIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CULTURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; INOCULATION; LUNG LAVAGE; MOUSE; MYCOPLASMA PNEUMONIAE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT INFECTION; ANIMAL; BACTERIAL COUNT; BAGG ALBINO MOUSE; CHEMISTRY; CLASSIFICATION; DISEASE MODEL; GROWTH, DEVELOPMENT AND AGING; HOSPITALIZATION; LUNG DISEASE; METABOLISM; MICROBIOLOGY; MYCOPLASMA PNEUMONIA; PATHOGENICITY;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BRONCHOALVEOLAR LAVAGE FLUID; COLONY COUNT, MICROBIAL; CYTOTOXINS; DISEASE MODELS, ANIMAL; FEMALE; LUNG DISEASES; MICE; MICE, INBRED BALB C; MYCOPLASMA PNEUMONIAE; PNEUMONIA, MYCOPLASMA; SEVERITY OF ILLNESS INDEX;

EID: 77957040139     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201001-0080OC     Document Type: Article

References (37)

1. Esposito S, Cavagna R, Bosis S, Droghetti R, Faelli N, Principi N. Emerging role of Mycoplasma pneumoniae in children with acute pharyngitis. Eur J Clin Microbiol Infect Dis 2002;21:607-610. (Pubitemid 35025020)
2. Waites KB, Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev 2004;17:697-728.
3. Block S, Hedrick J, Hammerschlag MR, Cassell GH, Craft JC. Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate. Pediatr Infect Dis J 1995;14:471-477.
4. Michelow IC, Olsen K, Lozano J, Rollins NK, Duffy LB, Ziegler T, Kauppila J, Leinonen M, McCracken GH Jr. Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics 2004;113:701-707.
5. Wubbel L, Muniz L, Ahmed A, Trujillo M, Carubelli C, McCoig C, Abramo T, Leinonen M, McCracken GH Jr. Etiology and treatment of community-acquired pneumonia in ambulatory children. Pediatr Infect Dis J 1999;18:98-104.
6. Gupta SK, Sarosi GA. The role of atypical pathogens in community-acquired pneumonia. Med Clin North Am 2001;85:1349-1365, vii.
7. Principi N, Esposito S. Emerging role of Mycoplasma pneumoniae and Chlamydia pneumoniae in paediatric respiratory-tract infections. Lancet Infect Dis 2001;1:334-344. (Pubitemid 33586614)
8. McIntosh K. Community-acquired pneumonia in children. N Engl J Med 2002;346:429-437.
9. Principi N, Esposito S, Blasi F, Allegra L; Mowgli study group. Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections. Clin Infect Dis 2001;32:1281-1289.
10. Kraft M. The role of bacterial infections in asthma. Clin Chest Med 2000;21:301-313.
11. Esposito S, Droghetti R, Bosis S, Claut L, Marchisio P, Principi N. Cytokine secretion in children with acute Mycoplasma pneumoniae infection and wheeze. Pediatr Pulmonol 2002;34:122-127. (Pubitemid 34809523)
12. Freymuth F, Vabret A, Brouard J, Toutain F, Verdon R, Petitjean J, Gouarin S, Duhamel JF, Guillois B. Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children. J Clin Virol 1999;13:131-139.
13. Daian CM, Wolff AH, Bielory L. The role of atypical organisms in asthma. Allergy Asthma Proc 2000;21:107-111.
14. Montalbano MM, Lemanske RF Jr. Infections and asthma in children. Curr Opin Pediatr 2002;14:334-337.
15. Esposito S, Blasi F, Arosio C, Fioravanti L, Fagetti L, Droghetti R, Tarsia P, Allegra L, Principi N. Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing. Eur Respir J 2000;16:1142-1146.
16. Baseman JB. The cytadhesins of Mycoplasma pneumoniae and M. genitalium. Subcell Biochem 1993;20:243-259.
17. Collier AM, Clyde WA. Relationships between Mycoplasma pneumoniae and human respiratory epithelium. Infect Immun 1971;3:694-701.
18. Baseman JB, Reddy SP, Dallo SF. Interplay between mycoplasma surface proteins, airway cells, and the protean manifestations of mycoplasma-mediated human infections. Am J Respir Crit Care Med 1996;154:S137-S144.
19. Krause DC. Mycoplasma pneumoniae cytadherence: organization and assembly of the attachment organelle. Trends Microbiol 1998;6:15-18.
20. Somerson NL, Walls BE, Chanock RM. Hemolysin of Mycoplasma pneumoniae: tentative identification as a peroxide. Science 1965;150:226-228.
21. Cherry JD, Taylor-Robinson D. Peroxide production by mycoplasmas in chicken tracheal organ cultures. Nature 1970;228:1099-1100.
22. Chiba H, Pattanajitvilai S, Mitsuzawa H, Kuroki Y, Evans A, Voelker DR. Pulmonary surfactant proteins A and D recognize lipid ligands on Mycoplasma pneumoniae and markedly augment the innate immune response to the organism. Chest 2003;123:426S.
23. Kannan TR, Baseman JB. ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens. Proc Natl Acad Sci USA 2006;103:6724-6729.
24. Su CJ, Chavoya A, Dallo SF, Baseman JB. Sequence divergency of the cytadhesin gene of Mycoplasma pneumoniae. Infect Immun 1990;58:2669-2674.
25. Broaders SA, Hooper WC, Phillips DJ, Talkington DF. Mycoplasma pneumoniae subtype-independent induction of proinflammatory cytokines in THP-1 cells. Microb Pathog 2006;40:286-292.
26. Dumke R, Catrein I, Herrmann R, Jacobs E. Preference, adaptation and survival of Mycoplasma pneumoniae subtypes in an animal model. Int J Med Microbiol 2004;294:149-155.
27. Hardy RD, Jafri HS, Olsen K, Wordemann M, Hatfield J, Rogers BB, Patel P, Duffy L, Cassell G, McCracken GH, Ramilo O. Elevated cytokine and chemokine levels and prolonged pulmonary airflow resistance in a murine Mycoplasma pneumoniae pneumonia model: a microbiologic, histologic, immunologic, and respiratory plethysmographic profile. Infect Immun 2001;69:3869-3876.
28. Fonseca-Aten M, Ríos AM, Mejías A, Chávez-Bueno S, Katz K, Gómez AM, McCracken GH Jr, Hardy RD. Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice. Am J Respir Cell Mol Biol 2005;32:201-210.
29. Tagliabue C, Salvatore CM, Techasaensiri C, Mejias A, Torres JP, Katz K, Gomez AM, Esposito S, Principi N, Hardy RD, et al. The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection. J Infect Dis 2008;198:1180-1188.
30. Cimolai N, Taylor GP, Mah D, Morrison BJ. Definition and application of a histopathological scoring scheme for an animal model of acute Mycoplasma pneumoniae pulmonary infection. Microbiol Immunol 1992;36:465-478.
31. Hewlett EL. Toxins. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases, 5th ed. Vol. 1. Philadelphia, PA: Churchill Livingstone; 2000. pp. 21-29.
32. Salvatore CM, Fonseca-Aten M, Katz-Gaynor K, Gomez AM, Hardy RD. Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia. Infect Immun 2008;76:732-738.
33. Woolard MD, Hardy RD, Simecka JW. IL-4-independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease. J Allergy Clin Immunol 2004;114:645-649.
34. Woolard MD, Hudig D, Tabor L, Ivey JA, Simecka JW. NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp. Infect Immun 2005;73:6742-6751.
35. Salvatore CM, Fonseca-Aten M, Katz-Gaynor K, Gomez AM, Mejias A, Somers C, Chavez-Bueno S, McCracken GH, Hardy RD. Respiratory tract infection with Mycoplasma pneumoniae in interleukin-12 knockout mice results in improved bacterial clearance and reduced pulmonary inflammation. Infect Immun 2007;75:236-242.
36. Chu HW, Honour JM, Rawlinson CA, Harbeck RJ, Martin RJ. Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice. Infect Immun 2003;71:1520-1526.
37. Hardy RD, Coalson JJ, Peters J, Chaparro A, Techasaensiri C, Cantwell AM, Kannan TR, Baseman JB, Dube PH. Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin. PLoS ONE 2009;4:e7562.