Emerging role of Mycoplasma pneumoniae and Chlamydia pneumoniae in paediatric respiratory-tract infections

Lancet Infectious Diseases

Volumn 1, Issue 5, 2001, Pages 334-344

  Principi, Nicola ^a   Esposito, Susanna ^b  

^a Italy Is Chair Paediatr Univ of   (Italy)

^b Is Director Lab Paediatr Dept U   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; MACROLIDE;

ABNORMAL RESPIRATORY SOUND; ADOLESCENT; BACTERIAL INFECTION; BACTERIAL PNEUMONIA; CHILD; CHLAMYDOPHILA PNEUMONIAE; COMMUNICABLE DISEASE; DRUG EFFECT; HUMAN; INFANT; ITALY; MICROBIOLOGY; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; PRESCHOOL CHILD; RESPIRATORY TRACT INFECTION; REVIEW;

ADOLESCENT; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; COMMUNITY-ACQUIRED INFECTIONS; HUMANS; INFANT; ITALY; MACROLIDES; MYCOPLASMA PNEUMONIAE; PNEUMONIA, BACTERIAL; PNEUMONIA, MYCOPLASMA; RESPIRATORY SOUNDS; RESPIRATORY TRACT INFECTIONS;

EID: 0035748752     PISSN: 14733099     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1473-3099(01)00147-5     Document Type: Review

References (84)

1. Fermald G.W., Collier A.M., Clyde W.A. Respiratory infections due to Mycoplasma pneumoniae in infants and children. Pediatrics. 55:1975;327-335.
2. Cassel G.H., Cole B.C. Mycoplasmas as agents of human disease. N Engl J Med. 304:1981;80-89.
3. Mok J.Y.Q., Waugh P.R., Simpson H. Mycoplasma pneumoniae infection. Arch Dis Child. 54:1979;506-511.
4. Sabato A.R., Martin A.J., Marmion B.P., Kok T.W., Cooper D.M. Mycoplasma pneumoniae: acute illness, antibiotics, and subsequent pulmonary function. Arch Dis Child. 59:1984;1034-1037.
5. Grayston J.T. Chlamydia pneumoniae (TWAR) infections in children. Pediatr Infect Dis J. 13:1994;675-685.
6. Hammerschlag M.R. The role of Chlamydia in upper respiratory tract infections. Curr Infect Dis Resp. 2:2000;115-120.
7. Esposito S, Blasi F, Droghetti R, et al. Emerging role of atypical bacteria in children with acute pharyngitis. Proceedings of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; 2001 Dec 16-19; Chicago (IL).
8. Principi N., Esposito S., Blasi F., Allegra L. Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections. Clin Infect Dis. 32:2001;1281-1289.
9. Esposito S., Blasi F., Arosio C., et al. Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infection in children with wheezing. Eur Resp J. 16:2000;1142-1146.
10. File T.M., Tan J.S., Plouffe J.F. The role of atypical pathogens: Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila in respiratory infection. Infect Dis Clin North Am. 12:1998;569-592.
11. Hammerschlag M.R. Mycoplasma pneumoniae infections. Curr Opin Infect Dis. 14:2001;181-186.
12. Blasi F., Cosentini R., Tarsia P. Chlamydia pneumoniae respiratory infections. Curr Opin Infect Dis. 13:2000;161-164.
13. Foy H.M., Cooney M.K., McMahan R., Grayston J.T. Viral and mycoplasmal pneumonia in a prepaid medical care group during an eight year period. Am J Epidemiol. 97:1973;93-102.
14. Foy H.M., Kenny G.E., McMahan R., Mansy A.M., Grayston J.T. Mycoplasma pneumoniae pneumonia in an urban area. Five years of surveillance. JAMA. 214:1970;1666-1672.
15. Thom D.H., Grayston J.T. Infections with Chlamydia pneumoniae strain TWAR. Clin Chest Med. 12:1991;245-256.
16. Mordhorst C.H., Wang S.P., Myhra W., Grayston J.T. Chlamydia pneumoniae, strain TWAR, infections in Denmark 1975-1987. Bowie W.R., Caldwell H.D., Jones R.P., et al. Chlamydial infections. 1990;418-421 Cambridge University Press, Cambridge, England.
17. Dominguez A., Minguell S., Torres J., Serrano A., Vidal J., Salleras L. Community outbreak of acute respiratory infection by Mycoplasma pneumoniae. Eur J Epidemiol. 12:1996;131-134.
18. Feikin D.R., Moroney J.F., Talkington D.F., et al. An outbreak of acute respiratory disease caused by Mycoplasma pneumoniae and adenovirus at federal service training academy: new implications from an old scenario. Clin Infect Dis. 29:1999;1545-1550.
19. Centers for Disease Control and Prevention. Outbreak of community-acquired pneumonia caused by Mycoplasma pneumoniae-Colorado, 2000. JAMA 2001; 285: 2073-2074.
20. Foy H.M., Kenny G.E., McMahan R., Kaiser G., Grayston J.T. Mycoplasma pneumoniae in the community. Am J Epidemiol. 93:1971;55-67.
21. Dorigo-Zetsma J.W., Wilbrink B., van der Nat H., Bartelds A.I.M., Heijnen M.L.A., Dankert J. Results of molecular detection of Mycoplasma pneumoniae among patients with acute respiratory infection and in their household contacts reveals children as human reservoir. J Infect Dis. 183:2001;675-678.
22. Blasi F., Cosentini R., Denti F., Allegra L. Two family outbreaks of Chlamydia pneumoniae infection. Eur Respir J. 7:1994;102-124.
23. Falck G., Gnarpe J., Gnarpe H. Prevalence of Chlamydia pneumoniae in healthy children and in children with respiratory tract infections. Pediatr Infect Dis J. 16:1997;549-554.
24. Normann E., Gnarpe J., Gnarpe H., Wettergren B. Chlamydia pneumoniae in children attending day-care centers in Gävle, Sweden. Pediatr Infect Dis J. 17:1998;474-478.
25. Mordhorst C.H., Wang S.P., Grayston J.T. Outbreak of Chlamydia pneumoniae infection in four farm families. Eur J Clin Microbiol. 11:1992;617-620.
26. Harris J.S., Kolokathis A., Campbell M., Cassell G., Hammerschlag M. Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children. Pediatr Infect Dis J. 17:1998;865-871.
27. Block S., Hedrick J., Hammerschlag M.R., Cassell G.H., Craft J.C. Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs erythromycin ethylsuccinate. Pediatr Infect Dis J. 14:1995;471-477.
28. Gnarpe J., Lundbäck A., Sundelöf B., Gnarpe H. Prevalence of Mycoplasma pneumoniae in subjectively healthy individuals. Scand J Infect Dis. 24:1992;161-164.
29. Hyman C.L., Roblin P.M., Gaydos C.A., Quinn T.C., Schachter J., Hammerschlag M.R. Prevalence of asymptomatic nasopharyngeal carriage of C pneumoniae in subjectively healthy adults: assessment by polymerase chain reaction-enzyme immunoassay and culture. Clin Infect Dis. 20:1995;1174-1178.
30. Hammerschlag M.R. Asymptomatic respiratory infection with Chlamydia pneumoniae. What does it mean? Chest. 119:2001;1303-1305.
31. Emre U., Roblin P.M., Gelling M., Dumornay W., Rao M., Hammerschlag M.R. The association of Chlamydia pneumoniae infection and reactive airway disease in children. Arch Pediatr Adolesc Med. 148:1994;727-732.
32. Kutlin A., Roblin P.M., Hammerschlag M.R. Antibody response to Chlamydia pneumoniae infection in children with respiratory illness. J Infect Dis. 177:1998;720-724.
33. Normann E., Gnarpe J., Gnarpe H., Wettergren B. Chlamydia pneumoniae in children with acute respiratory tract infections. Acta Paediatr. 87:1998;23-27.
34. Räty R., Kleemola M. Detection of Mycoplasma pneumoniae by polymerase chain reaction in middle ear fluids from infants with acute otitis media. Pediatr Infect Dis J. 19:2000;666-667.
35. Block S.L., Hammerschlag M.R., Hedrick J., et al. Chlamydia pneumoniae in acute otitis media. Pediatr Infect Dis J. 16:1997;858-862.
36. Storgaard M., Østergaard L., Jensen J.S., et al. Chlamydia pneumoniae in children with otitis media. Clin Infect Dis. 25:1997;1090-1093.
37. Falck G., Engstrand I., Gnarpe J., Gnarpe H. Association of Chlamydia pneumoniae with otitis media in children. Scand J Infect Dis. 30:1998;377-380.
38. Goo Y.A., Hori M.K., Voorhies J.H., Kuo C.C., Campbell L.A. Failure to detect Chlamydia pneumoniae in ear fluids from children with otitis media. Pediatr Infect Dis J. 14:1995;1000-1001.
39. Rosenblut A., Santolaya M.E., Gonzalez P., et al. Bacterial and viral etiology of acute otitis media in Chilean children. Pediatr Infect Dis J. 20:2001;501-507.
40. Engstrand I., Augustsson I., Bergemalm P.O., Falck G., Gnarpe J., Gnarpe H. Demonstration of Chlamydia pneumoniae in the adenoid from children with and without secretory otitis media using immunohistochemistry and PCR. Scand J Infect Dis. 33:2001;132-136.
41. Layani-Milon M.P., Gras I., Valette M., Luciani J., Stagnara J., Aymard M., Lina B. Incidence of upper respiratory tract Mycoplasma pneumoniae infections among outpatients in Rhone-Alpes, France, during five successive winter periods. J Clin Microbiol. 36:1999;1721-1726.
42. Hammerschlag M.R. Atypical pneumonias in children. Adv Pediatr Infect Dis. 10:1995;1-39.
43. Kim C.K., Chung C.Y., Kim J.S., Kim W.S., Park Y., Koh Y.Y. Late abnormal findings on high-resolution computed tomography after Mycoplasma pneumonia. Pediatrics. 105:2000;372-378.
44. Wubbel L., Muniz L., Ahmed A., et al. Etiology and treatment of community-acquired pneumonia in ambulatory children. Pediatr Infect Dis J. 18:1999;98-104.
45. Esposito S., Blasi F., Bellini F., Allegra L., Principi N. the Mowgli Study Group. Characteristics of Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with pneumonia. Eur Respir J. 17:2001;241-245.
46. Esposito S., Principi N. Asthma in children: are Chlamydia or Mycoplasma involved? Paediatr Drugs. 3:2001;159-168.
47. Gil J.C., Cedillo R.L., Mayagoitia B.G., Paz M.D. Isolation of Mycoplasma pneumoniae from asthmatic patients. Ann Allergy. 70:1993;23-25.
48. Kraft M., Cassell G.H., Henson J.E., et al. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am J Respir Crit Care Med. 158:1998;998-1001.
49. Cunningham A.F., Johnston S.L., Julious S.A., Lampe F.C., Ward M.E. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children. Eur Respir J. 11:1998;345-349.
50. Wubbel L., Jafri H.S., Olsen K., et al. Mycoplasma pneumoniae pneumonia in a mouse model. J Infect Dis. 178:1998;1526-1529.
51. Schemer-Avni Y., Lieberman D. Chlamydia pneumoniae-induced ciliostasis in ciliated bronchial epithelial cells. J Infect Dis. 171:1995;1274-1278.
52. Emre U., Sokolovskaya N., Roblin P.M., Schachter J., Hammerschlag M.R. Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease. J Infect Dis. 172:1995;265-267.
53. Martin R.J., Chu H.W., Honour J.M., Harbeck R.J. Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model. Am J Respir Cell Mol Biol. 24:2001;577-582.
54. Hardy R.D., Jafri H.S., Olsen K., et al. Elevated cytokine and chemokine levels and prolonged pulmonary airflow resistance in a murine Mycoplasma pneumoniae pneumonia model: a microbiologic, histologic, immunologic, and respiratory plethysmographic profile. Infect Immun. 69:2001;3869-3876.
55. Koh Y.Y., Park Y., Lee H.J., Kim C.K. Levels of interleukin-2, interferon-γ, and interleukin-4 in bronchoalveolar lavage fluid from patients with Mycoplasma pneumonia: implication of tendency toward increased immunoglobulin E production. Pediatrics. 107:2001;e39.
56. Halme S., Latvala J., Karttunen R., Palatsi I., Saikku P., Surcel H.M. Cell-mediated immune response during primary Chlamydia pneumoniae infection. Infect Immun. 68:2000;7156-7158.
57. Gaydos C.A. Growth in vascular cells and cytokine production by Chlamydia pneumoniae. J Infect Dis. 181:(suppl 3):2000;S473-S478.
58. Radisie M., Torn A., Gutierrez P., Defranchi H.A., Pardo P. Severe acute lung injury caused by Mycoplasma pneumoniae: potential role for steroid pulses in treatment. Clin Infect Dis. 31:2000;1507-1511.
59. ten Brinke A., van Dissel J.T., Sterk P.J., Zwindermann A.H., Rabe K.F., Bel E.H. Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. J Allergy Clin Immunol. 107:2001;449-454.
60. Hagiwara K., Ouchi K., Tashiro N., Azuma M., Kobayashi K. An epidemic of a pertussis-like illness caused by Chlamydia pneumoniae. Pediatr Infect Dis J. 18:1999;271-275.
61. Miller S.T., Hammerschlag M.R., Chirgwin K., Rao S.P., Roblin P., Gelling M., Stilerman T., Schachter J., Cassell G. Role of Chlamydia pneumoniae in acute chest syndrome of sickle cell disease. J Pediatr. 118:1991;30-33.
62. Clyde W.A. Clinical overview of typical Mycoplasma pneumoniae infections. Clin Infect Dis. 17:((suppl)):1993;32-36.
63. Foy H.M. Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients. Clin Infect Dis. 17:((suppl)):1993;37-46.
64. Heinemann M., Kem W.V., Bunjes D., Marre R., Essig A. Severe Chlamydia pneumoniae infection in patients with neutropenia: case reports and literature review. Clin Infect Dis. 31:2000;181-184.
65. Cosentini R., Esposito S., Blasi F., et al. Incidence of Chlamydia pneumoniae infection in vertically HIV-1 infected children. Eur J Clin Microbiol Infect Dis. 17:1998;720-723.
66. Emre U., Bernius M., Roblin P.M., et al. Chlamydia pneumoniae infection in patients with cystic fibrosis. Clin Infect Dis. 22:1996;819-823.
67. Plouffe J.F. Importance of atypical pathogens of community-acquired pneumonia. Clin Infect Dis. 31:(suppl 2):2000;S35-S39.
68. Toikka P., Juven T., Virkki R., Leinonen M., Merstola J., Ruuskanen O. Streptococcus pneumoniae and Mycoplasma pneumoniae coinfection in community acquired pneumonia. Arch Dis Child. 83:2000;413-414.
69. Waris M.E., Toikka P., Saarinen T., et al. Diagnosis of Mycoplasma pneumoniae pneumonia in children. J Clin Microbiol. 36:1998;3155-3159.
70. Dowell S.F., Peeling R.W., Boman J., et al. C pneumoniae Workshop Participants. Standardizing Chlamydia pneumoniae assay: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada). Clin Infect Dis. 33:2001;492-503.
71. Read T.D., Brunham R.C., Shen C., et al. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucl Acids Res. 28:2000;1397-1406.
72. Apfalter P., Blasi F., Boman J., et al. Multicenter comparison trial of DNA extraction methods and PCR assays for detection of Chlamydia pneumoniae in endarterectomy specimens. J Clin Microbiol. 39:2001;519-524.
73. Ieven M., Ursi D., Van Bever H., Quint W., Niesters H.G.M., Goossens H. Detection of Mycoplasma pneumoniae by two polymerase chain reactions and role of M pneumoniae in acute respiratory tract infections in pediatric patients. J Infect Dis. 173:1996;1445-1452.
74. Abele-Horn M., Busch U., Nitzschiko H., et al. Molecular approaches to diagnosis of pulmonary diseases due to Mycoplasma pneumoniae. J Clin Microbiol. 36:1998;548-551.
75. Blasi F., Boman J., Esposito G., et al. Chlamydia pneumoniae DNA detection in peripheral blood mononuclear cells is predictive of vascular infection. J Infect Dis. 180:1999;2074-2076.
76. Sprauer M.A., Cochi S.L., Zell E.R., et al. Prevention of secondary transmission of pertussis in households with early use of erythromycin. Am J Dis Child. 146:1992;177-181.
77. Taylor-Robinson D., Bebear C. Antibiotic susceptibilities of mycoplasmas and treatment of mycoplasmal infections. J Antimicrob Chemother. 40:1997;622-630.
78. Roblin P.M., Montalban G., Hammerschlag M.R. Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. Antimicrob Agents Chemother. 38:1994;1588-1589.
79. Roblin P.M., Hammerschlag M.R. Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia. Antimicrob Agents Chemother. 42:1998;194-196.
80. Hammerschlag M.R. Chlamydia pneumoniae and the lung. Eur Respir J. 16:2000;1001-1007.
81. Gendrel D., Raymond J., Moulin F., et al. Etiology and response to antibiotic therapy of community-acquired pneumonia in French children. Eur J Clin Microbiol Infect Dis. 16:1997;388-391.
82. Principi N., Esposito S. Comparative tolerability of erythromycin and newer macrolide antibacterials in paediatric patients. Drug Safety. 20:1999;25-41.
83. Klausner J.D., Passaro D., Rosenberg J., et al. Enhanced control of an outbreak of Mycoplasma pneumoniae pneumonia with azithromycin prophylaxis. J Infect Dis. 177:1998;161-166.
84. Hyde T.B., Gilbert M., Schwartz S.B., et al. Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia. J Infect Dis. 183:2001;907-912.