Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana

International Journal of Medical Microbiology

Volumn 300, Issue 7, 2010, Pages 489-495

  Homolka, Susanne ^a   Meyer, Christian G ^b   Hillemann, Doris ^a   Owusu Dabo, Ellis ^c,d   Adjei, Ohene ^c   Horstmann, Rolf D ^b   Browne, Edmund N L ^d   Chinbuah, Amanua ^e   Osei, Ivy ^e   Gyapong, John ^e   Kubica, Tanja ^a   Ruesch Gerdes, Sabine ^a   Niemann, Stefan ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c KUMASI CENTRE FOR COLLABORATIVE RESEARCH IN TROPICAL MEDICINE   (Ghana)

^d KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^e Health Research Unit Ghana Health Service   (Ghana)

Author keywords

Isoniazid resistance; M. africanum; M. tuberculosis; Rifampicin resistance

Indexed keywords

AHPC PROTEIN; BACTERIAL PROTEIN; FABG1 INHA PROTEIN; ISONIAZID; KATG PROTEIN; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; GHANA; HUMAN; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; MYCOBACTERIUM AFRICANUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GHANA; HUMANS; ISONIAZID; MUTATION; MYCOBACTERIUM; RIFAMPIN; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS;

EID: 77957021522     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2010.04.019     Document Type: Article

References (46)

1. Afanas'ev M.V., Ikryannikova L.N., Il'ina E.N., Sidorenko S.V., Kuz'min A.V., Larionova E.E., Smirnova T.G., Chernousova L.N., Kamaev E.Y., Skorniakov S.N., Kinsht V.N., Cherednichenko A.G., Govorun V.M. Molecular characteristics of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis isolates from the Russian Federation. J. Antimicrob. Chemother. 2007, 59:1057-1064.
2. Ali A., Hasan Z., Moatter T., Tanveer M., Hasan R. M. tuberculosis Central Asian Strain 1 MDR isolates have more mutations in rpoB and katG genes compared with other genotypes. Scand. J. Infect. Dis. 2009, 41:37-44.
3. Allix-Beguec C., Harmsen D., Weniger T., Supply P., Niemann S. Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolates. J. Clin. Microbiol. 2008, 46:2692-2699.
4. Bakonyte D., Baranauskaite A., Cicenaite J., Sosnovskaja A., Stakenas P. Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania. Antimicrob. Agents Chemother. 2003, 47:2009-2011.
5. Bercion R., Kuaban C. Initial resistance to antituberculosis drugs in Yaounde, Cameroon in 1995. Int. J. Tuberc. Lung Dis. 1997, 1:110-114.
6. Billington O.J., McHugh T.D., Gillespie S.H. Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 1999, 43:1866-1869.
7. Corbett E.L., Watt C.J., Walker N., Maher D., Williams B.G., Raviglione M.C., Dye C. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch. Intern. Med. 2003, 163:1009-1021.
8. Dalla Costa E.R., Ribeiro M.O., Silva M.S., Arnold L.S., Rostirolla D.C., Cafrune P.I., Espinoza R.C., Palaci M., Telles M.A., Ritacco V., Suffys P.N., Lopes M.L., Campelo C.L., Miranda S.S., Kremer K., da Silva P.E., Fonseca L.S., Ho J.L., Kritski A.L., Rossetti M.L. Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America. BMC Microbiol. 2009, 9:39.
9. de Jong B.C., Antonio M., Awine T., Ogungbemi K., de Jong Y.P., Gagneux S., DeRiemer K., Zozio T., Rastogi N., Borgdorff M., Hill P.C., Adegbola R.A. Use of spoligotyping and large sequence polymorphisms to study the population structure of the Mycobacterium tuberculosis complex in a cohort study of consecutive smear-positive tuberculosis cases in The Gambia. J. Clin. Microbiol. 2009, 47:994-1001.
10. Deutsches Institut für Normung (DIN) Methods for the Determination of Susceptibility of Tubercle Bacilli to Chemotherapeutic Agents. Norm 58943-8 1996, Beuth Verlag, Berlin, Germany.
11. DeVito J.A., Morris S. Exploring the structure and function of the mycobacterial KatG protein using trans-dominant mutants. Antimicrob. Agents Chemother. 2003, 47:188-195.
12. Doustdar F., Khosravi A.D., Farnia P., Masjedi M.R., Velayati A.A. Molecular analysis of isoniazid resistance in different genotypes of Mycobacterium tuberculosis isolates from Iran. Microb. Drug Resist. 2008, 14:273-279.
13. Evans J., Stead M.C., Nicol M.P., Segal H. Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa. J. Antimicrob. Chemother. 2009, 63:11-16.
14. Frothingham R., Strickland P.L., Bretzel G., Ramaswamy S., Musser J.M., Williams D.L. Phenotypic and genotypic characterization of Mycobacterium africanum isolates from West Africa. J. Clin. Microbiol. 1999, 37:1921-1926.
15. Gagneux S., Long C.D., Small P.M., Van T., Schoolnik G.K., Bohannan B.J. The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 2006, 312:1944-1946.
16. Githui W.A., Jordaan A.M., Juma E.S., Kinyanjui P., Karimi F.G., Kimwomi J., Meme H., Mumbi P., Streicher E.M., Warren R., van Helden P.D., Victor T.C. Identification of MDR-TB Beijing/W and other Mycobacterium tuberculosis genotypes in Nairobi, Kenya. Int. J. Tuberc. Lung Dis. 2004, 8:352-360.
17. Haas W.H., Bretzel G., Amthor B., Schilke K., Krommes G., Ruesch-Gerdes S., Sticht-Groh V., Bremer H.J. Comparison of DNA fingerprint patterns of isolates of Mycobacterium africanum from east and west Africa. J. Clin. Microbiol. 1997, 35:663-666.
18. Haas W.H., Schilke K., Brand J., Amthor B., Weyer K., Fourie P.B., Bretzel G., Sticht-Groh V., Bremer H.J. Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa. Antimicrob. Agents Chemother. 1997, 41:1601-1603.
19. Hillemann D., Kubica T., Ruesch-Gerdes S., Niemann S. Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany. Antimicrob. Agents Chemother. 2005, 49:1229-1231.
20. Homolka S., Post E., Oberhauser B., George A.G., Westman L., Dafae F., Ruesch-Gerdes S., Niemann S. High genetic diversity among Mycobacterium tuberculosis complex strains from Sierra Leone. BMC Microbiol. 2008, 8:103.
21. Kamerbeek J., Schouls L., Kolk A., van Agterveld M., van Soolingen D., Kuijper S., Bunschoten A., Molhuizen H., Shaw R., Goyal M., van Embden J. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J. Clin. Microbiol. 1997, 35:907-914.
22. Kent P., Kubica G. A guide for level III laboratory. Public Health Mycobacteriology 1985, US Department of Health and Human Services, Centre for Disease Control, Atlanta, GA.
23. Kiepiela P., Bishop K.S., Smith A.N., Roux L., York D.F. Genomic mutations in the katG, inhA and aphC genes are useful for the prediction of isoniazid resistance in Mycobacterium tuberculosis isolates from Kwazulu Natal, South Africa. Tuberc. Lung Dis. 2000, 80:47-56.
24. Lawn S.D., Frimpong E.H., Al-Ghusein H., Acheampong J.W., Uttley A.H., Butcher P.D., Griffin G.E. Pulmonary tuberculosis in Kumasi, Ghana: presentation, drug resistance, molecular epidemiology and outcome of treatment. West Afr. J. Med. 2001, 20:92-97.
25. Lipin M.Y., Stepanshina V.N., Shemyakin I.G., Shinnick T.M. Association of specific mutations in katG, rpoB, rpsL and rrs genes with spoligotypes of multidrug-resistant Mycobacterium tuberculosis isolates in Russia. Clin. Microbiol. Infect. 2007, 13:620-626.
26. Mariam D.H., Mengistu Y., Hoffner S.E., Andersson D.I. Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2004, 48:1289-1294.
27. Meissner G., Schröder K. The so-called African mycobacteria strains from the tropical West Africa. Zentralbl. Bakteriol. Orig. 1969, 211:69-81.
28. Mokrousov I., Narvskaya O., Otten T., Limeschenko E., Steklova L., Vyshnevskiy B. High prevalence of KatG Ser315Thr substitution among isoniazid-resistant Mycobacterium tuberculosis clinical isolates from northwestern Russia, 1996 to 2001. Antimicrob. Agents Chemother. 2002, 46:1417-1424.
29. Musser J.M. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev. 1995, 8:496-514.
30. Niemann S., Kubica T., Bange F.C., Adjei O., Browne E.N., Chinbuah M.A., Diel R., Gyapong J., Horstmann R.D., Joloba M.L., Meyer C.G., Mugerwa R.D., Okwera A., Osei I., Owusu-Darbo E., Schwander S.K., Ruesch-Gerdes S. The species Mycobacterium africanum in the light of new molecular markers. J. Clin. Microbiol. 2004, 42:3958-3962.
31. Niemann S., Ruesch-Gerdes S., Joloba M.L., Whalen C.C., Guwatudde D., Ellner J.J., Eisenach K., Fumokong N., Johnson J.L., Aisu T., Mugerwa R.D., Okwera A., Schwander S.K. Mycobacterium africanum subtype II is associated with two distinct genotypes and is a major cause of human tuberculosis in Kampala, Uganda. J. Clin. Microbiol. 2002, 40:3398-3405.
32. Owusu-Dabo E., Adjei O., Meyer C.G., Horstmann R.D., Enimil A., Kruppa T.F., Bonsu F., Browne E.N., Chinbuah M.A., Osei I., Gyapong J., Berberich C., Kubica T., Niemann S., Ruesch-Gerdes S. Mycobacterium tuberculosis drug resistance, Ghana. Emerg. Infect. Dis. 2006, 12:1171-1172.
33. Park Y.K., Shin S., Ryu S., Cho S.N., Koh W.J., Kwon O.J., Shim Y.S., Lew W.J., Bai G.H. Comparison of drug resistance genotypes between Beijing and non-Beijing family strains of Mycobacterium tuberculosis in Korea. J. Microbiol. Methods 2005, 63:165-172.
34. Ramaswamy S., Musser J.M. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuberc. Lung Dis. 1998, 79:3-29.
35. Riska P.F., Jacobs W.R., Alland D. Molecular determinants of drug resistance in tuberculosis. Int. J. Tuberc. Lung Dis. 2000, 4(Suppl. 1):S4-S10.
36. Slayden R.A., Barry C.E. The genetics and biochemistry of isoniazid resistance in Mycobacterium tuberculosis. Microbes Infect. 2000, 2:659-669.
37. Taniguchi H., Aramaki H., Nikaido Y., Mizuguchi Y., Nakamura M., Koga T., Yoshida S. Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosis. FEMS Microbiol. Lett. 1996, 144:103-108.
38. Tracevska T., Jansone I., Broka L., Marga O., Baumanis V. Mutations in the rpoB and katG genes leading to drug resistance in Mycobacterium tuberculosis in Latvia. J. Clin. Microbiol. 2002, 40:3789-3792.
39. Tudo G., Gonzalez J., Obama R., Rodriguez J.M., Franco J.R., Espasa M., Simarro P.R., Escaramis G., Ascaso C., Garcia A., Jimenez De Anta M.T. Study of resistance to anti-tuberculosis drugs in five districts of Equatorial Guinea: rates, risk factors, genotyping of gene mutations and molecular epidemiology. Int. J. Tuberc. Lung Dis. 2004, 8:15-22.
40. van der Werf T.S., Groothuis D.G., van Klingeren B. High initial drug resistance in pulmonary tuberculosis in Ghana. Tubercle 1989, 70:249-255.
41. van Embden J.D., Cave M.D., Crawford J.T., Dale J.W., Eisenach K.D., Gicquel B., Hermans P., Martin C., McAdam R., Shinnick T.M. Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J. Clin. Microbiol. 1993, 31:406-409.
42. Warren R.M., Streicher E.M., van Pittius N.C., Marais B.J., van der Spuy G.D., Victor T.C., Sirgel F., Donald P.R., van Helden P.D. The clinical relevance of Mycobacterial pharmacogenetics. Tuberculosis (Edinb.) 2009, 89:199-202.
43. World Health Organization Anti-tuberculosis Drug Resistance in the World: Report no. 4 2007, World Health Organization, Geneva, Switzerland.
44. World Health Organization Global Tuberculosis Control: Surveillance, Planning, Financing 2009, World Health Organization, Geneva, Switzerland.
45. Zaczek A., Brzostek A., Ugustynowicz-Kopec E., Zwolska Z., Dziadek J. Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin. BMC Microbiol. 2009, 9:10.
46. Zhang Y., Telenti A. Genetics of drug resistance in Mycobacterium tuberculosis. Molecular Genetics of Mycobacteria 2000, 235-251. ASM Press, Washington, DC. G.F. Harfull, W.R. Jacobs (Eds.).