A new potential anti-leukemia drug from a tropical plant

Leukemia Research

Volumn 34, Issue 11, 2010, Pages 1420-1421

  Gu, Bai Wei ^a   Mason, Philip J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti cancer; Leukemia; Natural products; New drugs; Typhonium flagelliforme

Indexed keywords

ANTILEUKEMIC AGENT; PLANT EXTRACT; TYPHONIUM FLAGELLIFORME EXTRACT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BONE MARROW TRANSPLANTATION; BREAST CANCER; CANCER CELL CULTURE; CANCER EPIDEMIOLOGY; CANCER GROWTH; CANCER HORMONE THERAPY; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RESEARCH; CANCER SURGERY; CANCER SURVIVAL; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG RESEARCH; EDITORIAL; HUMAN; LEUKEMIA; LEUKEMIA CELL; LIVER CANCER; LUNG CANCER; MEDICINAL PLANT; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; SURVIVAL RATE; SURVIVAL TIME; TYPHONIUM FLAGELLIFORME; ISOLATION AND PURIFICATION; PHYTOTHERAPY; PROCEDURES;

ANTINEOPLASTIC AGENTS; HUMANS; LEUKEMIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 77957017672     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.05.032     Document Type: Editorial

References (14)

1. Leukemia, Lymphoma, Myeloma, Facts 2009-2010. Leukemia and Lymphoma Society; 2009.
2. Hamilton G.R., Baskett T.F. In the arms of Morpheus the development of morphine for postoperative pain relief. Can J Anaesth 2000, 47(4):367-374.
3. Newman D.J., Cragg G.M., Snader K.M. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003, 66(7):1022-1037.
4. Butle M.S. The role of natural product chemistry in drug discovery. J Nat Prod 2004, 67(12):2141-2153.
5. Li J.W., Vederas J.C. Drug discovery and natural products: end of an era or an endless frontier?. Science 2009, 325(5937):161-165.
6. Butler M.S. Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep 2005, 22(2):162-195.
7. Weissman K.J., Leadlay P.F. Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol 2005, 3(12):925-936.
8. Newman D.J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. J Med Chem 2008, 51(9):2589-2599.
9. Neoh C.K. Typhonium divaricatum (rodent tuber): a promising local plant in the fight against cancer. Med J Malaysia 1992, 47(1):86-88.
10. Mohan S., Bustamam A., Ibrahim S., Al-Zubairi A.S., Aspollah M. Anticancerous effect of Typhonium flagelliforme on human t4-lymphoblastoid cell line CEM-ss. J Pharmacol Toxicol 2008, 3:449-456.
11. Lai C.S., Mas R., Nair N.K., Majid M.I.A., Mansor S.M., Navaratnam V. Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis: an evaluation by the bioactivity guided approach. J Ethnopharmacol 2008, 118(1):14-20.
12. Chan L.K., Koh W.Y., Tengku-Muhammad T.S. Comparison of cytotoxic activities between in vitro and field grown plants of Typhonium flagelliforme (Lodd.) Blume. J Plant Biol 2005, 48(1):25-31.
13. Choo C.Y., Chan K.L., Takeya K., Itokawa H. Cytotoxic activity of Typhonium flagelliforme (Araceae). Phytother Res 2001, 15(3):260-262.
14. Mohan S., Abdul A.B., Abdelwahab S.I., Al-Zubairi A.S., Sukari M.A., Abdullah R., et al. Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo. Leuk Res 2010, 34:1483-1492.