Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo

Leukemia Research

Volumn 34, Issue 11, 2010, Pages 1483-1492

  Mohan, Syam ^a   Abdul, Ahmad Bustamam ^a   Abdelwahab, Siddig Ibrahim ^a   Al Zubairi, Adel S ^a,b   Aspollah Sukari, Mohamed ^a   Abdullah, Rasedee ^a   Taha, Manal Mohamed Elhassan ^a   Beng, Ng Kuan ^a   Isa, Nurbaity Mohd ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b SANA A UNIVERSITY   (Yemen)

Author keywords

Apoptosis; BALB c mice; Cytotoxicity; Typhonium flagelliforme; WEHI 3 leukemia cells

Indexed keywords

ACETIC ACID ETHYL ESTER; CYTOTOXIC AGENT; DICHLOROMETHANE; DIMETHYL SULFOXIDE; HEXANE; METHANOL; OLIVE OIL; PLANT EXTRACT; TYPHONIUM FLAGELLIFORME EXTRACT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARACEAE; ARTICLE; BAGG ALBINO MOUSE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG MECHANISM; DRUG TOLERABILITY; FLUORESCENCE MICROSCOPY; GRANULOCYTE; HISTOPATHOLOGY; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LEUKOCYTE COUNT; LIVER STRUCTURE; MALE; MONOCYTE; MOUSE; MURINE LEUKEMIA; MYELOMONOCYTIC LEUKEMIA; NONHUMAN; PERIPHERAL CIRCULATION; PLANT LEAF; PLANT TUBER; PRIORITY JOURNAL; SINGLE DRUG DOSE; SPLEEN BIOPSY; SPLEEN WEIGHT; TREATMENT DURATION; TYPHONIUM FLAGELLIFORME; ANIMAL; DRUG EFFECTS; IC50; ISOLATION AND PURIFICATION; LEUKEMIA; MEDICINAL PLANT; PATHOLOGY; SPLEEN; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; INHIBITORY CONCENTRATION 50; LEUKEMIA; METHYLENE CHLORIDE; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; PLANTS, MEDICINAL; SPLEEN;

EID: 77957016582     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.04.023     Document Type: Article

References (33)

1. Lee S.J., Kim K.H., Park J.S., Jung J.W., Kim Y.H., Kim S.K., et al. Comparative analysis of cell surface proteins in chronic and acute leukemia cell lines. Biochem Biophys Res Commun 2007, 357:620-626.
2. Lim G.C.C. Overview of cancer in Malaysia. Jpn J Clin Oncol 2002, 32:S37-S42.
3. Rates S.M.K. Plants as source of drugs. Toxicon 2001, 39:603-613.
4. Neoh C.K. Typhonium divaricatum (rodent tuber): a promising local plant in the fight against cancer. Med J Malaysia 1992, 47:86.
5. Lai C.S., Mas R., Nair N.K., Majid M.I.A., Mansor S.M., Navaratnam V. Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis: an evaluation by the bioactivity guided approach. J Ethnopharmacol 2008, 118:14-20.
6. Syam M., Ahmad B., Siddig I., Adel S.A., Mohamed A. Anticancerous effect of Typhonium flagelliforme on human T4 lymphoblastoid cell line CEMss. J Pharmacol Toxicol 2008, 3:449-456.
7. Chan L.K., Koh W.Y., Tengku-Muhammad T.S. Comparison of cytotoxic activities between in vitro and field grown plants of Typhonium flagelliforme (Lodd.) Blume. J Plant Biol 2005, 48:25-31.
8. Lai C.S., Mas R.H., Nair N.K., Mansor S.M., Navaratnam V. Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae). J Ethnopharmacol 2010, 127:486-494.
9. Choo C.Y., Chan K.L., Takeya K., Itokawa H. Cytotoxic activity of Typhonium flagelliforme (Araceae). Phytother Res 2001, 15:260-262.
10. Lam K.S. New aspects of natural products in drug discovery. Trends Microbiol 2007, 15:279-289.
11. Issa A.Y., Volate S.R., Wargovich M.J. The role of phytochemicals in inhibition of cancer and inflammation: new directions and perspectives. J Food Compost Anal 2006, 19:405-419.
12. Gullo V.P., Hughes D.E. Exploiting new approaches for natural product drug discovery in the biotechnology industry. Drug Discov Today: Technol 2005, 2:281-286.
13. Dahanukar S.A., Kulkarni R.A., Rege N.N. Pharmacology of medicinal plants and natural products. Indian J Pharmacol 2000, 32:81-118.
14. Marks D.C., Belov L., Davey M.W., Davey R.A., Kidman A.D. The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells. Leuk Res 1992, 16:1165-1173.
15. Phillips R.M., Jaffar M., Maitland D.J., Loadman P.M., Shnyder S.D., Steans G., et al. Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs. Biochem Pharmacol 2004, 68:2107-2116.
16. Steenkamp V., Gouws M.C. Cytotoxicity of six South African medicinal plant extracts used in the treatment of cancer. S Afr J Bot 2006, 72:630-633.
17. Douer D., Tallman M.S. Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies. J Clin Oncol 2005, 23:2396.
18. Lim H.K., Moon J.Y., Kim H., Cho M., Cho S.K. Induction of apoptosis in U937 human leukaemia cells by the hexane fraction of an extract of immature Citrus grandis Osbeck fruits. Food Chem 2009, 114:1245-1250.
19. Hodek P., Kížková J., Burdová K., Šulc M., Kizek R., Hudecek J., et al. Chemopreventive compounds-view from the other side. Chem Biol Interact 2009, 180:1-9.
20. Warner N.L., Moore M.A., Metcalf D. A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content. J Natl Cancer Inst 1969, 43:963.
21. Yu F.S., Wu C.C., Chen C.T., Huang S.P., Yang J.S., Hsu Y.M., et al. Diallyl sulfide inhibits murine WEHI-3 leukemia cells in BALB/c mice in vitro and in vivo. Hum Exp Toxicol 2009, 10.1177/0960327109350670.
22. He Q., Na X. The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo. Leuk Res 2001, 25:455-461.
23. Lin J.P., Yang J.S., Lu C.C., Chiang J.H., Wu C.L., Lin J.J., et al. Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo. Leuk Res 2009, 33:823-828.
24. Chung J.G., Yang J.S., Huang L.J., Lee F.Y., Teng C.M., Tsai S.C., et al. Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics 2007, 7:3305-3317.
25. Li J., Sartorelli A.C. Synergistic induction of the differentiation of WEHI-3B D+ myelomonocytic leukemia cells by retinoic acid and granulocyte colony-stimulating factor. Leuk Res 1992, 16:571-576.
26. Tsou M.F., Peng C.T., Shih M.C., Yang J.S., Lu C.C., Chiang J.H., et al. Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo. Leuk Res 2009, 33:1505-1511.
27. de Both N.J., Klootwijk E., Verhoef N.J., Schalekamp M., Harrison P.R., Stoof T.J. The influence of Rauscher leukemia virus (R-MuLV) on the differentiation of red blood cells in BALB/c mice. Leuk Res 1979, 3:227-238.
28. Rojas R., Roman J., Herrera C., Alvarez M.A., Ramirez R., Torres A. BALB/C mice injected with LSTRA leukemic cell line are cured by in vivo treatment with IL-2+ GM-CSF. Leuk Res 2003, 27:351-357.
29. Anderson E.R., Xiong H., Gendelman HE Animal model systems of HIV-diseases. In vivo models of HIV disease and control 2005, Springer publication, pp. 19-25.
30. Haseman J.K., Lockhart A. The relationship between use of the maximum tolerated dose and study sensitivity for detecting rodent carcinogenicity. Fundam Appl Toxicol 1994, 22:382-391.
31. Gad S.C., Philip W. Maximum Tolerated Dose (MTD). Encyclopedia of Toxicology 2005, Elsevier, New York, pp. 21-2.
32. Yu C.S., Lai K.C., Yang J.S., Chiang J.H., Lu C.C., Wu C.L., et al. Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response. Phytother Res 2009, 10.1002/ptr.2841.
33. Vaughan M.R., Pippin J.W., Griffin S., Krofft R., Fleet M., Haseley L., et al. ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro and in vivo. Kidney Int 2005, 68:133-144.