Drug-induced changes in action potential duration are proportional to action potential duration in rat ventricular myocardium

General Physiology and Biophysics

Volumn 29, Issue 3, 2010, Pages 309-313

  Bárándi, László ^a   Harmati, Gábor ^a   Horváth, Balázs ^a   Szentandrássy, Norbert ^a   Magyar, János ^a   Varró, András ^b   Nánási, Péter P ^a   Bányász, Tamás ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Action potential duration; Electrical restitution; Membrane current; Reverse rate dependence; Ventricular repolarization

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; NIFEDIPINE; POTASSIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL; ARTICLE; CONTROLLED STUDY; DIASTOLE; HEART MUSCLE; HEART RATE; HEART REPOLARIZATION; HEART RIGHT VENTRICLE FUNCTION; ION CURRENT; MAGNITUDE ESTIMATION METHOD; NONHUMAN; RAT;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; DOGS; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GUINEA PIGS; HEART; HUMANS; MALE; MODELS, CARDIOVASCULAR; NIFEDIPINE; POTASSIUM CHANNEL BLOCKERS; RABBITS; RATS; RATS, WISTAR; SPECIES SPECIFICITY; TETRAETHYLAMMONIUM;

CAVIA; MAMMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 77957010985     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: 10.4149/gpb_2010_03_309     Document Type: Article

References (14)

1. Apkon M., Nerbonne J. M. (1991): Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes. J. Gen. Physiol. 97, 973-1011; doi:10.1085/jgp.97.5.973
2. Bányász T., Horváth B., Virág L., Bárándi L., Szentandrássy N., Harmati G., Magyar J., Marangoni S., Zaza A., Varró A., Nánási P. P. (2009): Reverse rate dependency is an intrinsic property of canine cardiac preparations. Cardiovasc. Res. 84, 237-244; doi:10.1093/cvr/cvp213
3. Bárándi L., Virág L., Jost N., Horváth Z., Koncz I., Papp R., Harmati G., Horváth B., Szentandrássy N., Bányász T., Magyar J., Zaza A., Varró A., Nánási P. P. (2010): Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations. Basic Res. Cardiol. 105, 315-323; doi:10.1007/s00395-009-0082-7
4. Carmeliet E. (1977): Repolarization and frequency in cardiac cells. J. Physiol. (Paris) 73, 903-923
5. Hondeghem L. M., Katzung B. G. (1977): Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta 472, 373-398
6. Josephson I. R., Sanches-Chapula J., Brown A. M. (1984): Early outward current in rat single ventricular cells. Circ. Res. 54, 157-162
7. Jurkiewicz N. K., Sanguinetti M. C. (1993): Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ. Res. 72, 75-83
8. Mitchell M. R., Powell T., Terrar D. A., Twist V. W. (1984): Strontium, nifedipine and 4-aminopyridine modify the time course of the action potential in cells from rat ventricular muscle. Br. J. Pharmacol. 81, 551-556
9. Rocchetti M., Besana A., Gurrola G.B., Possani L. D., Zaza A. (2001): Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J. Physiol. (London) 534, 721-732; doi:10.1111/j.1469-7793. 2001.00721.x
10. Shigematsu S., Kiyosue T., Sato T., Arita M. (1997): Rate-dependent prolongation of action potential duration in isolated rat ventricular myocytes. Basic Res. Cardiol. 92, 123-128; doi:10.1007/BF00788629
11. Szigligeti P., Pankucsi C., Bányász T., Varró A., Nánási P. P. (1996): Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle. J. Comp. Physiol. B 166, 150-155; doi:10.1007/BF00301179
12. Virág L., Acsai K., Hála O., Zaza A., Bitay M., Bogáts G., Papp J. G., Varró A. (2009): Self augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implication for reverse rate dependency. Br. J. Pharmacol. 156, 1076-1084; doi:10.1111/j.1476-5381.2009.00116.x
13. Yang T., Roden D. M. (1996): Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation 93, 407-411
14. Yuan W., Ginsburg K. S., Bers D. M. (1996): Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes. J. Physiol. (London) 493, 733-746