Hypoglycemic effect, biochemical and histological changes of Spondias mombin linn, and Parinari polyandra benth. seeds ethanolic extracts in alloxan-induced diabetic rats

Journal of Pharmacology and Toxicology

Volumn 6, Issue 2, 2010, Pages 101-112

  Iweala, Emeka E J ^a   Oludare, Funmilayo D ^a  

^a Covenant University ^*  (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALLOXAN; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; GLUTATHIONE; PARINARI POLYANDRA EXTRACT; PLANT EXTRACT; SPONDIAS MOMBIN EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PROTEIN;

ADIPOCYTE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENTIATION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; LIPID PEROXIDATION; LIVER HISTOLOGY; MALE; MEDICINAL PLANT; NONHUMAN; PARINARI POLYANDRA; PLANT SEED; PROTEIN BLOOD LEVEL; RAT; SOXHLET EXTRACTION; SPONDIAS MOMBIN; TRIACYLGLYCEROL BLOOD LEVEL; ALLOXAN-INDUCED DIABETES MELLITUS; ANTIDIABETIC ACTIVITY; BIOCHEMISTRY; BLOOD ANALYSIS; HISTOLOGY; HYPERGLYCEMIA; LIVER; WEIGHT CHANGE;

EID: 77957006836     PISSN: 1816496X     EISSN: 2152100X     Source Type: Journal    
DOI: 10.3923/jpt.2011.101.112     Document Type: Article

References (67)

1. Abdel-Barry, J.A., LA. Abdel-Hassan and M.H.H. Al-Hakiem, 1997. Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J. Ethnopharmacol., 58: 149-155.
2. Abolaji, O.A., A.H. Adebayo and O.S. Odesanmi, 2007. Nutritional qualities of three medicinal plant parts Xylopia aethiopica, Blighia sapida and Parinari polyandra commonly used by pregnant women in the western part of Nigeria. Pak. J. Nutr., 6: 665-668.
3. Adeneye, A.A. and E.O. Agbaje, 2008. Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of morinda lucida benth in normal and alloxan-induced diabetic rats. Afr. J. Biomed. Res., 11: 65-71.
4. Adewole, S.O. and E.A. Caxton-Martins, 2006. Morphological changes and hypoglycemic effects of Annona Muricata Linn. (Annonaceae) leaf aqueous extract on pancreatic A-cells of streptozotocin-treated diabetic rats. Afr. J. Biomed. Res., 9: 173-180.
5. Adewunmi, CO. and J.A.O. Ojewole, 2004. Safety of traditional medicines complementary and alternatives medicines in Africa. Afr. J. Trad. CAM, 1: 1-3.
6. Ajao, O., O. Shonukan and B. Femi-onadeko, 1985. Antibacterial effect of aqueous and alcohol extracts of spondias mombin and alchornea cordifolia - two local antimicrobial remedies. Pharm. Biol, 23: 67-72.
7. Alarcon-Aguilar, F.J., F. Calzada-Bermejo, E. Hernandez-Galicia, C. Ruiz-Angeles and R. Roman-Ramos, 2005. Acute and chronic hypoglycaemic effect of Ibervillea sonorae root extracts-II. J. Ethnopharmacol., 97: 447-452.
8. Aliyu, R., A.H. Adebayo, D. Gatsing and I.H. Garba, 2007. The effects of ethanolic leaf extract of Commiphora africana (Burseraceae) on rat liver and kidney functions. J. Pharmacol. ToxicoL, 2: 373-379.
9. Anuradha, C.V. and R. Selvam, 1993. Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats. J. Nutr. Biochem., 4: 212-217.
10. Ayoka, A.O., R.O. Akomolafe, E.O. Iwalewa and O.E. Ukponmwan, 2005. Studies on the anxiolytic effect of Spondias mombin L. (Anacardiaceae) extracts. Afr. J. Trad. C.A.M., 2: 153-165.
11. Babu, V., T. Gangadevi and A. Subramanium, 2002. Antihyperglycemic activity of Cassia kleinii leaf extract in glucose feed normal rats and alloxan-induced diabetic rats. Indian J. Pharmacol., 34: 409-415.
12. Bhandarkar, M. and A. Khan, 2004. Antihepatotoxic effect of Nymphaea stellatawilld against carbon tetrachloride-induced hepatic damage in albino rats. J. Ethnopharmacol., 91: 61-64.
13. Brai, B.I.C., A.A. Odetola and P.U. Agomo, 2007. Hypoglycemic and hypocholesterolemic potential of Persea americana leaf extracts. J. Med. Food., 10: 356-360.
14. Brownlee, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414: 813-820.
15. Buege, J.A. and S.D. Aust, 1978. Microsomal Lipid Peroxidation. In: Methods of Enzymology, Fleischer, S. and L. Packer (Eds.), Academic Press, New York, pp: 302-310.
16. Calixto, J.B., 2000. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicine (Phytotherapeutic agents). Braz. J. Med. Biol. Res., 33: 179-189.
17. Chaude, M.A, O.E. Onsakwe, O.J. Afonne, K.S. Gamemal, O.H. Vongtau and E. Obi, 2001. Hypoglycemic effect of the aqueous extract of Boerrhavia diffusa leaves. Indian J. Pharmacol., 33:215-216.
18. Dhandapani, S., V.R. Subramanian, S. Rajagopal and N. Namasivayam, 2002. Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats. Pharmacol. Res., 46: 251-255.
19. Disbrey, B.D. and J.H. Rack, 1970. Histological Laboratory Methods. Livingstone, Edinburgh, ISBN: 0443006946, pp: 56-128.
20. El-Demerdash, F.M., M.I. Yousef and N.I. El-Naga, 2005. Biochemical study on the hypoglycemic effects of onion and garlic in alloxon-induced diabetes rats. Food Chem. ToxicoL, 43: 57-63.
21. Ellman, G.L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82: 70-77.
22. Fayed, T., M.A. El-Missiry, H. Emara and N. El-Sayaad, 1998. Effect of Nigella sativa or fish oil supplementation in alloxan diabetic rats. J. Union. Arab. Biol., 9: 237-250.
23. Felig, P.E., J.L. Ohman and G.F. Chall, 1970. Plasma amino acid levels in diabetic ketoacidosis. Diabetes, 19: 727-734.
24. Fred-Jaiyesimi, A.A., M.R. Wilkins and K.A. Abo, 2009. Hypoglycaemic and aniylase inhibitory activities of leaves of Spondias mombin Linn. Afr. J. Med. Med. Sci., 38: 343-349.
25. Gandhipuram, P.S.K., A. Palanisamy, S.K. Durairaj and P.S. Sorimuthu, 2006. Anti diabetic activity of fruits of Terminalia chebula on streptozotocin-induced diabetic rats. J. Health Sci., 52:283-291.
26. Gondwe, M., D.R. Kamadyaapa, M.A. Tufts, A.A. Chuturgoon, J.A.O. Ojewole and C.T. Musabayane, 2008. Effects of Persea americana Mill (Lauraceae) (Avocado) ethanolic extract on blood glucose and kidney function in streptozotocin- induced diabetic rats and on kidney cell lines of the proximal (LLCPK 1) and distal tubules (MDBK). Meth. Find. Exp. Chn. Pharmacol, 30: 25-35.
27. Hossain, U.S.K. and S. Bhattacharya, 2006. Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates. Environ. Toxicol. Pharmacol, 22: 298-308.
28. Iweala, E.E.J. and C.U. Okeke, 2005. Comparative study of the hypoglycemic and biochemical effects of Catharanthus roseus and chlorpropamide on alloxan-induced diabetic rats. Biokermstri, 17: 149-156.
29. Kikkawa, R, D. Koya and M. Haneda, 2003. Progress of diabetic neuropathy. Am. J Kidney Dis, 41: 19-21.
30. Krishna, B, S. Nammi, M.K. Kota and R.V. Krishna Rao, 2004. Evaluation of hypoglycaemic and antihyperglycemic effects of Datura metel Linn seeds in normal and alloxan-induced diabetic rats. J. Ethnopharmacol, 91: 95-98.
31. Krishnakumar, K, K.T. Augustii and P.L. Vijayammal, 1999. Hypoglycaemic and anti-oxidant activity of Salacia oblonga Wall, extract in streptozotocin-induced diabetic rats. Indian J. Physiol. Pharmacol, 43: 510-514.
32. Lans, C, 2007. Ethnomedicines used in Trinidad and Tobago for reproductive problems. J. Ethnobiol. Ethnomed, 3: 13-13.
33. Lowry, O.H, N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem, 193: 265-275.
34. Lyons, T.J, 1991. Oxidized low-density lipoproteins, a role in the pathogenesis of atherosclerosis in diabetes. Diabet Med, 8: 411-419.
35. Maroo, J, V.T. Vasu and S. Gupta, 2003. Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale blume in alloxan induced diabetic rats. Phytomedicine, 10: 196-199.
36. Metz, S.A, 1984. Is phospholipase A2 a glucose sensor responsible for the phasic pattern of insulin release?. Prostaglandins, 27: 147-151.
37. Mironova, M, R. Klein, G. Virella and M. Lopes-Virella, 2000. Anti-Modified LDL antibodies, LDL-containing immune complexes and susceptibility of LDL to in vitro oxidation in patients with type 2 diabetes. Diabetes, 49: 1033-1041.
38. Momo, C.E.N, J.E. Oben, D. Tazoo and E. Dongo, 2006. Antidiabetic and hypolipeniic effects of laportea ovalifolia (urticaceae) in alloxan induced diabetic rats. Afr. J. Trad. CAM, 3: 36-43.
39. Muthulingam, M, 2010. Antidiabetic efficacy of leaf extracts of Asteracantha longifolia (Linn.) Nees. on alloxan induced diabetics in male albino wistar rats. Int. J. Pharm. Biomed. Res, 1: 28-34.
40. Nelson, D.L. and M.M. Cox, 2005. Lehninger; Principles of Biochemistry. 4th Edn, W.H. Freeman and Company, New York.
41. Nicotera, P. and S. Orrenius, 1986. Role of thiols in protection against biological reactive intermediates. Adv. Exp. Med. Biol., 197: 41-49.
42. Njoku, P.C. and M.I. Akumefula, 2007. Phytochemical and nutrient evaluation of spondias mombin leaves. Pak. J. Nutr., 6: 613-615.
43. Odetola, A.A., O. Akmloye, C. Egunjobi, W.A. Adekunle and A.O. Ayoola, 2006. Possible antidiabetic and antihyperlipidaeniic effect of fermented Parkia Biglobosa (JACQ) extract in alloxan-induced diabetic rats. Clin. Exp. Pharmacol. Physiol., 33: 808-812.
44. Okigbo, R.N. and E.C. Mmeka, 2006. An appraisal of phytomedicine in Africa. KMITL Sci. Tech. J, 6: 83-94.
45. Okolie, U.V., C.E. Okeke, J.M. Oli and I.O. Ehiemere, 2008. Hypoglycemic indices of Vernonia amygdalina on postprandial blood glucose concentration of healthy humans. Afr. J. Biotechnol., 7: 4581-4585.
46. Oladele, S.B., J.O. Ayo and A.O. Adaudi, 1995. Medicinal and physiological properties of flavonoids, coumarin derivatives and anthraquinones of plant origin. W. Afr. J. Pharmacol. Drug Res., 11: 134-144.
47. Pari, L. and S. Amarnath, 2004. Antidiabetic activity of Boerhavia diffusa L. effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol., 91: 109-113.
48. Pepato, M.T., A.M. Baviera, R.C. Vendramini, M.P. Perez, I.C. Kettelhut and I.L. Brunetti, 2003. Cissus sicyoides (Princess wine) in the long terme treatment of streptozotocin - diabetic rats. Biotchnol. Applied Biochem., 37: 15-20.
49. Piedrola, G., E. Novo, F. Escober and R. Garcia-Robles, 2001. White blood cell count and insulin resistance in patients with coronary artery disease. Ann. Endocrinol., (Paris), 62: 7-10.
50. Rajagopal, K. and K. Sasikala, 2008. Antihyperglycaemic and antihyperlipidaeniic effects of Nymphaea stellata in alloxan-induced diabetic rats. Singapore Med. J., 49: 137-141.
51. Raji, Y., M.A. Gbadegesin, O.A. Osonuga, R.A. Adisa and O.S. Akinsomisoye et al., 2006. Reproductive, haematologic and biochemical profile of male rats treated with aqueous extract of Spondias mombinharh. Int. J. Pharmacol., 2: 126-130.
52. Ravikuniar, P. and C.V. Anuradha, 1999. Effect of Fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytother. Res., 13: 197-201.
53. Ross, R.N., 1999. Mechanisms of disease: Atherosclerosis-an inflammatory disease. New Engl. J. Med, 340: 115-126.
54. Schwartz, S.L, 2006. Diabetes and dyslipidemias. Diabetes Obes. Metab, 8: 355-364.
55. Sharma, S.B, A. Nasir, K.M. Prabhu, P.S. Murthy and G. Dev, 2003. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J. Ethanopharmacol, 85: 201-206.
56. Srinivasan, M, M. Padmanabhan and P.S. Prince, 2005. Effect of aqueous Enicostemma littorale blume extract on key carbohydrate metabolic enzymes, lipid peroxides and antioxidants in alloxan-induced diabetic rats. J. Pharm. Pharmacol, 57: 497-503.
57. Szkudelski, T, 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res, 50: 537-546.
58. Tiwari, A.K. and J. Madhusudana-Rao, 2002. Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Curr. Sci, 83: 30-38.
59. Udoh, E.A, N. Iya, E. Okon and N. Mary, 2007. Red cell catalase activity in diabetics. Pak. J. Nutr, 6: 511-515.
60. Vats, V, J.K. Grover and S.S. Rathi, 2002. Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J. Ethnopharmacol, 79: 95-100.
61. Virella-Lopes, M.F. and G. Virella, 2003. The role of immune and inflammatory processes in the development of macrovascular disease in diabetes. Fron. Biosci., 8: 750-768.
62. Vlassara, H., M. Brownlee and A. Cerami, 1981. Nonenzymatic glycosylation of peripheral nerve protein in diabetes melhtus. PNAS, 78: 5190-5192.
63. Vongtau, H.O, J. Abbah, I.E. Ngazal, O.F. Kunle, B.A. Chindo and P.B. Otsapa, 2004. Anti-nociceptive and anti-inflammatory activities of the methanolic extract of Parinari polyandra stem bark in rats and mice. J. Ethnopharmacol., 90: 115-121.
64. WHO, 1999. Definition Diagnosis and Classification of Diabetes Melhtus andits Complications. Part 1: Diagnosis and Classification of Diabetes. WHO/NCD/NCS 99, 2, Geneva, pp: 1-58.
65. WHO, 2002. WHO news: Traditional medicine strategy launched. Bull. World Health Organization, 80: 610-610.
66. Wild, S., G. Roglic, A. Green, R. Sicree and H. King, 2004. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care., 27: 1047-1053.
67. Yaryura-Tobias, J.A., A. Pinto and F. Neziroglu, 2001. Anorexia nervosa, diabetes melhtus, brain atrophy and fatty liver. Int. J. Eating Disorders, 30: 350-353.