Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats

Pharmacological Research

Volumn 62, Issue 5, 2010, Pages 400-407

  Elmarakby, Ahmed A ^a   Faulkner, Jessica ^a   Posey, Sam P ^a   Sullivan, Jennifer C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

8 Isoprostane; COX2; Hemeoxygenase 1; Hypertension; MCP 1; Proteinuria

Indexed keywords

8 ISOPROSTANE; C REACTIVE PROTEIN; CYCLOOXYGENASE 2; HEME OXYGENASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PORPHYRIN DERIVATIVE; PROTOPORPHYRIN COBALT; STANNOUS MESOPORPHYRIN; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HYPERTENSION; HYPOTHESIS; MALE; MEAN ARTERIAL PRESSURE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; URINARY EXCRETION; WISTAR KYOTO RAT;

ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; CATALASE; ENZYME INDUCTION; HEME OXYGENASE-1; HYPERTENSION; INFLAMMATION; KIDNEY; MALE; METALLOPORPHYRINS; OXIDATIVE STRESS; PROTOPORPHYRINS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 77956941393     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.07.005     Document Type: Article

References (39)

1. Wang R., Shamloul R., Wang X., Meng Q., Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension 2006, 48:685-692.
2. Keyhani S., Scobie J.V., Hebert P.L., McLaughlin M.A. Gender disparities in blood pressure control and cardiovascular care in a national sample of ambulatory care visits. Hypertension 2008, 51:1149-1155.
3. Elks C.M., Mariappan N., Haque M., Guggilam A., Majid D.S., Francis J. Chronic nf-{kappa}b blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in shr. Am J Physiol Renal Physiol 2009, 296:F298-F305.
4. Choi B.S., Yang H.J., Ahn K.O., Lim S.W., Kim S.H., Kim J.Y., et al. Renoprotective effects of rosiglitazone in stroke-prone spontaneously hypertensive rats. Kidney Blood Press Res 2007, 30:212-223.
5. Biswas S.K., de Faria J.B. Which comes first: renal inflammation or oxidative stress in spontaneously hypertensive rats?. Free Radic Res 2007, 41:216-224.
6. Miyagawa K., Ohashi M., Yamashita S., Kojima M., Sato K., Ueda R., et al. Increased oxidative stress impairs endothelial modulation of contractions in arteries from spontaneously hypertensive rats. J Hypertens 2007, 25:415-421.
7. Turkseven S., Kruger A., Mingone C.J., Kaminski P., Inaba M., Rodella L.F., et al. Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes. Am J Physiol Heart Circ Physiol 2005, 289:H701-707.
8. Barbagallo I., Tibullo D., Di Rosa M., Giallongo C., Palumbo G.A., Raciti G., et al. A cytoprotective role for the heme oxygenase-1/co pathway during neural differentiation of human mesenchymal stem cells. J Neurosci Res 2008, 86:1927-1935.
9. Morimoto K., Ohta K., Yachie A., Yang Y., Shimizu M., Goto C., et al. Cytoprotective role of heme oxygenase (ho)-1 in human kidney with various renal diseases. Kidney Int 2001, 60:1858-1866.
10. Botros F.T., Schwartzman M.L., Stier C.T., Goodman A.I., Abraham N.G. Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. Kidney Int 2005, 2745-2755.
11. Abraham N.G., Kushida T., McClung J., Weiss M., Quan S., Lafaro R., et al. Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ Res 2003, 93:507-514.
12. Stocker R., McDonagh A.F., Glazer A.N., Ames B.N. Antioxidant activities of bile pigments: biliverdin and bilirubin. Methods Enzymol 1990, 186:301-309.
13. Vera T., Kelsen S., Yanes L.L., Reckelhoff J.F., Stec D.E. Ho-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin ii hypertensive mice. Am J Physiol Regul Integr Comp Physiol 2007, 292:R1472-1478.
14. Yang L., Quan S., Nasjletti A., Laniado-Schwartzman M., Abraham N.G. Heme oxygenase-1 gene expression modulates angiotensin ii-induced increase in blood pressure. Hypertension 2004, 43:1221-1226.
15. Olszanecki R., Rezzani R., Omura S., Stec D.E., Rodella L., Botros F.T., et al. Genetic suppression of ho-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway. Am J Physiol Renal Physiol 2007, 292:F148-157.
16. Wiesel P., Patel A.P., Carvajal I.M., Wang Z.Y., Pellacani A., Maemura K., et al. Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res 2001, 88:1088-1094.
17. Tian N., Moore R.S., Phillips W.E., Lin L., Braddy S., Pryor J.S., et al. Nadph oxidase contributes to renal damage and dysfunction in dahl salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol 2008, 295:R1858-1865.
18. Tian N., Moore R.S., Braddy S., Rose R.A., Gu J.W., Hughson M.D., et al. Interactions between oxidative stress and inflammation in salt-sensitive hypertension. Am J Physiol Heart Circ Physiol 2007, 293:H3388-3395.
19. Elmarakby A.A., Imig J.D. Obesity is the major contributor to vascular dysfunction and inflammation in high fat diet hypertensive rats. Clin Sci (Lond) 2009.
20. Sullivan J.C., Sasser J.M., Pollock J.S. Sexual dimorphism in oxidant status in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 2007, 292:R764-768.
21. Sasser J.M., Sullivan J.C., Elmarakby A.A., Kemp B.E., Pollock D.M., Pollock J.S. Reduced nos3 phosphorylation mediates reduced no/cgmp signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats. Hypertension 2004, 43:1080-1085.
22. Ndisang J.F., Wu L., Zhao W., Wang R. Induction of heme oxygenase-1 and stimulation of cgmp production by hemin in aortic tissues from hypertensive rats. Blood 2003, 101:3893-3900.
23. Abraham N.G., Botros F.T., Rezzani R., Rodella L., Bianchi R., Goodman A.I. Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in shr. Cell Mol Biol (Noisy-le-grand) 2002, 48:895-902.
24. Cao J., Drummond G., Inoue K., Sodhi K., Li X.Y., Omura S. Upregulation of heme oxygenase-1 combined with increased adiponectin lowers blood pressure in diabetic spontaneously hypertensive rats through a reduction in endothelial cell dysfunction, apoptosis and oxidative stress. Int J Mol Sci 2008, 9:2388-2406.
25. Ndisang J.F., Lane N., Syed N., Jadhav A. Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 2010, 151:549-560.
26. Ahmad M., Turkseven S., Mingone C.J., Gupte S.A., Wolin M.S., Abraham N.G. Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats. Cell Mol Biol (Noisy-le-grand) 2005, 51:371-376.
27. Zhou H., Liu H., Porvasnik S.L., Terada N., Agarwal A., Cheng Y., et al. Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension. Lab Invest 2006, 86:62-71.
28. Akamatsu Y., Haga M., Tyagi S., Yamashita K., Graca-Souza A.V., Ollinger R., et al. Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J 2004, 18:771-772.
29. Ndisang J.F., Zhao W., Wang R. Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 2002, 40:315-321.
30. Sabaawy H.E., Zhang F., Nguyen X., ElHosseiny A., Nasjletti A., Schwartzman M., et al. Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension 2001, 38:210-215.
31. Rao F., Wessel J., Wen G., Zhang L., Rana B.K., Kennedy B.P., et al. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Hypertension 2007, 49:1015-1031.
32. Peixoto E.B., Pessoa B.S., Biswas S.K., Lopes de Faria J.B. Antioxidant sod mimetic prevents nadph oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and hypertension. Am J Nephrol 2009, 29:309-318.
33. Abraham N.G., Kappas A. Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med 2005, 39:1-25.
34. Datla S.R., Dusting G.J., Mori T.A., Taylor C.J., Croft K.D., Jiang F. Induction of heme oxygenase-1 in vivo suppresses nadph oxidase derived oxidative stress. Hypertension 2007, 50:636-642.
35. Feletou M., Vanhoutte P.M. Endothelial dysfunction: a multifaceted disorder (the wiggers award lecture). Am J Physiol Heart Circ Physiol 2006, 291:H985-1002.
36. Jadhav A., Torlakovic E., Ndisang J.F. Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats. Am J Physiol Renal Physiol 2009, 296:F521-534.
37. Paravicini T.M., Touyz R.M. Nadph oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 2008, 31(Suppl. 2):S170-S180.
38. Tracz M.J., Juncos J.P., Croatt A.J., Ackerman A.W., Grande J.P., Knutson K.L., et al. Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia. Kidney Int 2007, 72:1073-1080.
39. Patrono C., Ciabattoni G., Pugliese F., Pierucci A., Blair I.A., FitzGerald G.A. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 1986, 77:590-594.