The cannabinoid 1 receptor antagonist AM251 produces nocifensive behavior via activation of ERK signaling pathway

Neuropharmacology

Volumn 59, Issue 6, 2010, Pages 534-541

  Katsuyama, Soh ^a   Mizoguchi, Hirokazu ^b   Komatsu, Takaaki ^a   Nagaoka, Kohshi ^b   Sakurada, Shinobu ^b   Sakurada, Tsukasa ^a  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cannabinoid 1 (CB1) receptor antagonist; Extracellular signal regulated kinase (ERK); Intrathecal (i.t.) injection; Neuronal nitric oxide synthase (nNOS); Nitric oxide (NO); Spinal cord

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CANNABINOID 1 RECEPTOR AGONIST; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CHLOROETHYL)EICOSATETRAENAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROKININ 1 RECEPTOR ANTAGONIST; NEURONAL NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BITE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; LICKING; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INJECTIONS, SPINAL; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE I; PAIN MEASUREMENT; PHOSPHORYLATION; PIPERIDINES; PYRAZOLES; RECEPTORS, CANNABINOID; SPINAL CORD;

EID: 77956941035     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.07.015     Document Type: Article

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