Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia

Journal of Neuroscience

Volumn 18, Issue 1, 1998, Pages 451-457

  Richardson, Jennelle Durnett ^a,d   Aanonsen, Lin ^b   Hargreaves, Kenneth M ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MACALESTER COLLEGE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Endogenous cannabinoid; Glutamate; Hyperalgesia; NMDA; Nociceptive threshold; Spinal cord; SR 141716A; Tonic

Indexed keywords

CANNABINOID; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; RIMONABANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; EVOKED RESPONSE; HYPERALGESIA; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; ONCOGENE C FOS; PAIN THRESHOLD; PRIORITY JOURNAL; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 0031974179     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-01-00451.1998     Document Type: Article

References (5)

1. Aanonsen LM, Wilcox GL (1987) Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. J Pharmacol Exp Ther 243:9-19.
2. Besson J-M, Chaouch A (1987) Peripheral and spinal mechanisms of nociception. Pharmacol Rev 67:67-186.
3. 2+ current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism. Br J Pharmacol 106:231-232.
4. Chavez-Noriega LE, Stevens CF (1994) Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices. J Neurosci 14:310-317.
5. 9-tetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther 277:586-594.