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Volumn 14, Issue 5, 2010, Pages 1221-1228

Development of an efficient synthesis of two CRF antagonists for the treatment of neurological disorders

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL STUDY; EFFICIENT SYNTHESIS; NEUROLOGICAL DISORDERS; PALLADIUM-CATALYZED CYANATION; ZINC ACETATE;

EID: 77956931055     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op1001512     Document Type: Article
Times cited : (17)

References (49)
  • 15
    • 77956915500 scopus 로고    scopus 로고
    • For an example of a Suzuki coupling using a 5-chloropyrazinone under microwave irradiation see
    • For an example of a Suzuki coupling using a 5-chloropyrazinone under microwave irradiation see
  • 29
    • 77956902255 scopus 로고    scopus 로고
    • For reviews of the vicarious nucleophilic substitution reaction see
    • For reviews of the vicarious nucleophilic substitution reaction see
  • 33
    • 77956934778 scopus 로고    scopus 로고
    • For a strategy to install a difluoromethyl group on the nitrogen atom of a 2-pyridinone see
    • For a strategy to install a difluoromethyl group on the nitrogen atom of a 2-pyridinone see
  • 35
    • 77956928778 scopus 로고    scopus 로고
    • The heat of reaction =+436.9 kJ/mol; T adiabatic = +242.6 K
    • The heat of reaction =-436.9 kJ/mol; T adiabatic = +242.6 K.
  • 38
    • 77956919776 scopus 로고    scopus 로고
    • 2 reductions see
    • 2 reductions see
  • 42
    • 77956919222 scopus 로고    scopus 로고
    • For an example of zinc acetate improving the conversion of a palladium-catalyzed cyanation see
    • For an example of zinc acetate improving the conversion of a palladium-catalyzed cyanation see
  • 46
    • 77956931889 scopus 로고    scopus 로고
    • For an example of additive effects on cyanide solubility see
    • For an example of additive effects on cyanide solubility see
  • 48
    • 77956912402 scopus 로고    scopus 로고
    • The stability of P-3 relative to that of N-2 and N-4 is unclear because it is a transient polymorph only obtained during the N-1 to N-3 conversion
    • The stability of P-3 relative to that of N-2 and N-4 is unclear because it is a transient polymorph only obtained during the N-1 to N-3 conversion.
  • 49
    • 77956901714 scopus 로고    scopus 로고
    • The level of residual zinc was <10 ppm, and the level of residual NMP was <0.02 wt %.
    • The level of residual zinc was <10 ppm, and the level of residual NMP was <0.02 wt %.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.