Bullous dermatosis associated with IgG antibodies specific for desmocollins

European Journal of Dermatology

Volumn 20, Issue 5, 2010, Pages 620-625

  Endo, Yuichiro ^a   Tsujioka, Kaoru ^b   Tanioka, Miki ^a   Minegaki, Yusuke ^b   Ohyama, Bungo ^c   Hashimoto, Takashi ^c   Miyachi, Yoshiki ^a   Utani, Atsushi ^a,d  

^a KYOTO UNIVERSITY   (Japan)

^b JAPANESE RED CROSS WAKAYAMA MEDICAL CENTER   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NAGASAKI UNIVERSITY   (Japan)

Author keywords

Desmocollin; IgA pemphigus; Paraneoplastic pemphigus

Indexed keywords

AUTOANTIBODY; CELL SURFACE IMMUNOGLOBULIN; DESMOCOLLIN; DESMOGLEIN 1 ANTIBODY; DESMOGLEIN 3 ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MINOCYCLINE; PREDNISOLONE;

ACANTHOLYSIS; ADULT; ANAMNESIS; ARTICLE; BLADDER; BLISTER; BULLOUS DERMATITIS; CANCER STAGING; CASE REPORT; CELL LINE; CLINICAL FEATURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; EPIDERMIS; ERYTHEMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; KERATINOCYTE; MALE; NEUTROPHIL; PARANEOPLASTIC PEMPHIGUS; PEMPHIGOID; PEMPHIGUS VULGARIS; PUSTULE; STOMACH CANCER;

ANTIBODY SPECIFICITY; COMORBIDITY; DESMOCOLLINS; DESMOGLEIN 1; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PEMPHIGUS; SKIN DISEASES, VESICULOBULLOUS; STOMACH NEOPLASMS;

EID: 77956927193     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2010.1020     Document Type: Article

References (36)

1. Chen J, Den Z, Koch PJ. Loss of desmocollin 3 in mice leads to epidermal blistering. J Cell Sci 2008; 121: 2844-9.
2. Chidgey MA, Yue KK, Gould S, et al. Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development. Dev Dyn 1997; 210: 315-27. (Pubitemid 27498152)
3. King IA, Angst BD, Hunt DM, et al. Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse. Differentiation 1997; 62: 83-96. (Pubitemid 27499486)
4. Nuber UA, Schafer S, Stehr S, et al. Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. Eur J Cell Biol 1996; 71: 1-13.
5. Theis DG, Koch PJ, Franke WW. Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia. Int J Dev Biol 1993; 37: 101-10.
6. Yasuda H, Kobayashi H, Hashimoto T, et al. Subcorneal pustular dermatosis type of IgA pemphigus: demonstration of autoantibodies to desmocollin-1 and clinical review. Br J Dermatol 2000; 143: 144-8. (Pubitemid 30485258)
7. Bolling MC, Mekkes JR, Goldschmidt WF, et al. Acquired palmoplantar keratoderma and immunobullous disease associated with antibodies to desmocollin 3. Br J Dermatol 2007; 157: 168-73.
8. Hashimoto T, Amagai M, Watanabe K, et al. A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins. J Invest Dermatol 1995; 104: 541-4.
9. Heng A, Nwaneshiudu A, Hashimoto T, et al. Intraepidermal neutrophilic IgA/IgG antidesmocollin 1 pemphigus. Br J Dermatol 2006; 154: 1018-20.
10. Hisamatsu Y, Amagai M, Garrod DR, et al. The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirus-expressed proteins, in atypical pemphigus but not in typical pemphigus. Br J Dermatol 2004; 151: 73-83. (Pubitemid 39061282)
11. Hashimoto T, Komai A, Futei Y, et al. Detection of IgA autoantibodies to desmogleins by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus. Arch Dermatol 2001; 137: 735-8. (Pubitemid 32577854)
12. Karlhofer FM, Hashimoto T, Slupetzky K, et al. 230-kDa and 190-kDa proteins in addition to desmoglein 1 as immunological targets in a subset of pemphigus foliaceus with a combined cell-surface and basement membrane zone immune staining pattern. Exp Dermatol 2003; 12: 646-54. (Pubitemid 37270727)
13. Dmochowski M, Nie Z, Kiyokawa C, et al. Human desmocollin 1a transiently expressed in COS-7 cells and NIH 3T3-3 cells is reacted by IgG4 antibodies in a pemphigus foliaceus serum. J Dermatol Sci 1999; 21: 42-8. (Pubitemid 29347110)
14. Niimi Y, Kawana S, Kusunoki T. IgA pemphigus: a case report and its characteristic clinical features compared with subcorneal pustular dermatosis. J Am Acad Dermatol 2000; 43: 546-9.
15. Petropoulou H, Politis G, Panagakis P, et al. Immunoglobulin A pemphigus associated with immunoglobulin A gammopathy and lung cancer. Journal of Dermatology 2008; 35: 341-5.
16. Hashimoto T, Kiyokawa C, Mori O, et al. Human desmocollin 1 (Dsc1) is an autoantigen for the subcorneal pustular dermatosis type of IgA pemphigus. J Invest Dermatol 1997; 109: 127-31. (Pubitemid 27337324)
17. Ishii N, Ishida-Yamamoto A, Hashimoto T. Immunolocalization of target autoantigens in IgA pemphigus. Clin Exp Dermatol 2004; 29: 62-6. (Pubitemid 38183655)
18. Hashimoto T, Yasumoto S, Nagata Y, et al. Clinical, histopathological and immunological distinction in two cases of IgA pemphigus. Clin Exp Dermatol 2002; 27: 636-40. (Pubitemid 35454219)
19. Gruss C, Zillikens D, Hashimoto T, et al. Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin. J Am Acad Dermatol 2000; 43: 923-6.
20. Hashimoto T, Ebihara T, Dmochowski M, et al. IgA antikeratinocyte surface autoantibodies from two types of intercellular IgA vesiculopustular dermatosis recognize distinct isoforms of desmocollin. Arch Dermatol Res 1996; 288: 447-52.
21. Hashimoto K, Hashimoto T, Higashiyama M, et al. Detection of anti-desmocollins I and II autoantibodies in two cases of Hallopeau type pemphigus vegetans by immunoblot analysis. J Dermatol Sci 1994; 7: 100-6.
22. Kozlowska A, Hashimoto T, Jarzabek-Chorzelska M, et al. Pemphigus herpetiformis with IgA and IgG antibodies to desmoglein 1 and IgG antibodies to desmocollin 3. J Am Acad Dermatol 2003; 48: 117-22.
23. Preisz K, Horvath A, Sardy M, et al. Exacerbation of paraneoplastic pemphigus by cyclophosphamide treatment: detection of novel autoantigens and bronchial autoantibodies. Br J Dermatol 2004; 150: 1018-24.
24. Gooptu C, Mendelsohn S, Amagai M, et al. Unique immunobullous disease in a child with a predominantly IgA response to three desmosomal proteins. Br J Dermatol 1999; 141: 882-6.
25. Taintor AR, Leiferman KM, Hashimoto T, et al. A novel case of IgA paraneoplastic pemphigus associated with chronic lymphocytic leukemia. J Am Acad Dermatol 2007; 56: S73-6.
26. Duparc A, Boivin S, Gilbert D, et al. Paraneoplastic pemphigus with pemphigus vegetans-like lesions revealing non-Hodgkin lymphoma. Eur J Dermatol 2006; 16: 698-9.
27. Anhalt GJ, Kim SC, Stanley JR, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990; 323: 1729-35.
28. Chorzelski TP, Hashimoto T, Nishikawa T, et al. Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II. J Am Acad Dermatol 1994; 31: 351-5.
29. Barnadas MA, Curell R, Alomar A, et al. Paraneoplastic pemphigus with negative direct immunofluorescence in epidermis or mucosa but positive findings in adnexal structures. J Cutan Pathol 2008.
30. Marinkovich MP, Taylor TB, Keene DR, et al. LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. J Invest Dermatol 1996; 106: 734-8.
31. Camisa C, Helm TN. Paraneoplastic pemphigus is a distinct neoplasia-induced autoimmune disease. Arch Dermatol 1993; 129: 883-5.
32. Joly P, Richard C, Gilbert D, et al. Sensitivity and specificity of clinical, histologic and immunologic features in the diagnosis of paraneoplastic pemphigus. J Am Acad Dermatol 2000; 43: 619-26.
33. Marsden MD, Collins JE, Greenwood MD, et al. Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2). Gene 1997; 186: 237-47.
34. Fairley JA, Woodley DT, Chen M, et al. A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading. J Am Acad Dermatol 2004; 51: 118-22.
35. Muller R, Heber B, Hashimoto T, et al. Autoantibodies against desmocollins in European patients with pemphigus. Clin Exp Dermatol 2009; 34: 898-903.
36. Ishii N, Ohyama B, Yamaguchi Z, et al. IgA autoantibodies against the NC16a domain of BP180 but not 120-kDa LAD-1 detected in a patient with linear IgA disease. Br J Dermatol 2008; 158: 1151-3.