메뉴 건너뛰기




Volumn 26, Issue 4, 2010, Pages 324-336

Levosimendan treatment of myocardial depression in sepsis: A case series and review of the literature;Tratamiento de la depresión miocárdica por sepsis con levosimendan. Serie de casos y revisión de la bibliografía

Author keywords

Calcium sensitizers; Heart failure; Inotropes; Levosimendan; Septic cardiomyopathy; Septic shock

Indexed keywords

AMIKACIN; ANIDULAFUNGIN; CATECHOLAMINE; CEFTAZIDIME; CEFTRIAXONE; CILASTATIN PLUS IMIPENEM; CLARITHROMYCIN; CREATININE; ERTAPENEM; LACTIC ACID; LEVOFLOXACIN; LEVOSIMENDAN; LINEZOLID; MEROPENEM; METRONIDAZOLE; MOXIFLOXACIN; NORADRENALIN; OSELTAMIVIR; PIPERACILLIN PLUS TAZOBACTAM; VANCOMYCIN; VASOACTIVE AGENT; VASOPRESSIN;

EID: 77956925701     PISSN: 01864866     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (81)
  • 1
    • 0022628578 scopus 로고
    • New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments
    • Colucci WS, Wright RF, Braunwald E. New positive inotropic agents in the treatment of congestive heart failure: mechanisms of action and recent clinical developments. N Engl J Med 1986;314:349-358. (Pubitemid 16166262)
    • (1986) New England Journal of Medicine , vol.314 , Issue.6 , pp. 349-358
    • Colucci, W.S.1    Wright, R.F.2    Braunwald, E.3
  • 2
    • 0034739460 scopus 로고    scopus 로고
    • Acute hemodynamic and clinical effects of Levosimendan in patients with severe heart failure
    • Slawsky MT, Colucci WS, Gottlieb SS. Acute hemodynamic and clinical effects of Levosimendan in patients with severe heart failure. Circulation 2000;102: 2222-2227.
    • (2000) Circulation , vol.102 , pp. 2222-2227
    • Slawsky, M.T.1    Colucci, W.S.2    Gottlieb, S.S.3
  • 3
  • 4
    • 0023180312 scopus 로고
    • Survival in congestive heart failure during treatment with drugs with positive inotropic actions
    • Packer M, Leier CV. Survival in congestive heart failure during treatment with drugs with positive inotropic actions. Circulation 1987;75:(Suppl 4):55-63.
    • (1987) Circulation , vol.75 , Issue.SUPPL. 4 , pp. 55-63
    • Packer, M.1    Leier, C.V.2
  • 5
    • 0024988171 scopus 로고
    • Effect of milrinone on ventricular arrhythmias in congestive heart failure
    • Ferrick KJ, Fein SA, Ferrick AM. Effect of milrinone on ventricular arrhythmias in congestive heart failure. Am J Cardiol 1990;66:431-434.
    • (1990) Am J Cardiol , vol.66 , pp. 431-434
    • Ferrick, K.J.1    Fein, S.A.2    Ferrick, A.M.3
  • 6
    • 0024319042 scopus 로고
    • Myocardial energetic in patients with dilated cardiomyopathy
    • Hasenfuss G, Holubarsch C, Heiss HW. Myocardial energetic in patients with dilated cardiomyopathy. Circulation 1989;80:51-64.
    • (1989) Circulation , vol.80 , pp. 51-64
    • Hasenfuss, G.1    Holubarsch, C.2    Heiss, H.W.3
  • 7
    • 0013302144 scopus 로고    scopus 로고
    • Calcium sensitivity enhancers
    • Haikala H, Pollesello P. Calcium sensitivity enhancers. Drugs 2000;3:1199-1205.
    • (2000) Drugs , vol.3 , pp. 1199-1205
    • Haikala, H.1    Pollesello, P.2
  • 8
    • 0002807086 scopus 로고
    • Intermittent dobutamine in ambulatory outpatients with chronic cardiac failure
    • Dies F, Krell MJ, Whitlow P. Intermittent dobutamine in ambulatory outpatients with chronic cardiac failure. Circulation 1986;74(Suppl 2):389.
    • (1986) Circulation , vol.74 , Issue.SUPPL. 2 , pp. 389
    • Dies, F.1    Krell, M.J.2    Whitlow, P.3
  • 9
    • 0024988171 scopus 로고
    • Effect of milrinone on ventricular arrhythmias in congestive heart failure
    • Ferrick KJ, Fein SA, Ferrick AM. Effect of milrinone on ventricular arrhythmias in congestive heart failure. Am J Cardiol 1990;66:431-434.
    • (1990) Am J Cardiol , vol.66 , pp. 431-434
    • Ferrick, K.J.1    Fein, S.A.2    Ferrick, A.M.3
  • 10
    • 0037454137 scopus 로고    scopus 로고
    • Heart failure etiology and response to milrinone in decompensated heart failure: Results from the OPTIME-CHF study
    • Felker GM, Benza RL, Chandler AB. Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study. J Am Coll Cardiol 2003;41: 997-1003.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 997-1003
    • Felker, G.M.1    Benza, R.L.2    Chandler, A.B.3
  • 11
    • 21344469500 scopus 로고    scopus 로고
    • In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications. An analysis from the acute decompensated heart failure national registry (ADHERE)
    • Abraham WT, Adams KF, Fonarow GC. In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications. An analysis from the acute decompensated heart failure national registry (ADHERE). J Am Coll Cardiol 2005;46:57-64.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 57-64
    • Abraham, W.T.1    Adams, K.F.2    Fonarow, G.C.3
  • 12
    • 0032541979 scopus 로고    scopus 로고
    • Influence of the novel inotropic agent levosimedan on isometric tension and calcium cycling in failing human myocardium
    • Hasenfuss G, Pieske B, Castell M. Influence of the novel inotropic agent levosimedan on isometric tension and calcium cycling in failing human myocardium. Circulation 1998;98:2141-2147.
    • (1998) Circulation , vol.98 , pp. 2141-2147
    • Hasenfuss, G.1    Pieske, B.2    Castell, M.3
  • 13
    • 0034666682 scopus 로고    scopus 로고
    • Levosimendan improves diastolic and systolic function in failing human myocardium
    • Janssen PM, Datz N, Zeitz O. Levosimendan improves diastolic and systolic function in failing human myocardium. Eur J Pharmacol 2000;404:191-199.
    • (2000) Eur J Pharmacol , vol.404 , pp. 191-199
    • Janssen, P.M.1    Datz, N.2    Zeitz, O.3
  • 14
    • 0030918670 scopus 로고    scopus 로고
    • Levosimendan enhances left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy
    • Pagel PS, McGough MF, Hettrick DA. Levosimendan enhances left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy. J Cardiovasc Pharmacol 1997;29:563-573.
    • (1997) J Cardiovasc Pharmacol , vol.29 , pp. 563-573
    • Pagel, P.S.1    McGough, M.F.2    Hettrick, D.A.3
  • 15
    • 12344307837 scopus 로고    scopus 로고
    • Levosimendan improves left ventricular systolic and diastolic performance at rest and during exercise after heart failure
    • Tachibana H, Cheng H, Ukai T. Levosimendan improves left ventricular systolic and diastolic performance at rest and during exercise after heart failure. Am J Physiol Heart Circ Physiol 2005; 288:H914-H922
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Tachibana, H.1    Cheng, H.2    Ukai, T.3
  • 16
    • 0029583354 scopus 로고
    • Effects of calcium sensitizers on intracellular calcium handling and myocardial energetic
    • Hasenfuss G, Pieske B, Kretschmann B, et al. Effects of calcium sensitizers on intracellular calcium handling and myocardial energetic. J Cardiovasc Pharmacol 1995;26(Suppl 1): S45-51.
    • (1995) J Cardiovasc Pharmacol , vol.26 , Issue.SUPPL. 1
    • Hasenfuss, G.1    Pieske, B.2    Kretschmann, B.3
  • 17
    • 0029613261 scopus 로고
    • Mechanisms of action of calcium-sensitizing drugs
    • Haikala H, Linden IB. Mechanisms of action of calcium-sensitizing drugs. J Cardiovasc Pharmacol 1995;26:S10-19.
    • (1995) J Cardiovasc Pharmacol , vol.26
    • Haikala, H.1    Linden, I.B.2
  • 18
    • 25144451694 scopus 로고    scopus 로고
    • Pharmacology of new agents for acute heart failure syndromes
    • Gheorghiade M, Terrlink JR, Mebazaa A. Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol 2005;96:68-73.
    • (2005) Am J Cardiol , vol.96 , pp. 68-73
    • Gheorghiade, M.1    Terrlink, J.R.2    Mebazaa, A.3
  • 19
    • 0030608872 scopus 로고    scopus 로고
    • + channel in rat arterial myocytes
    • DOI 10.1016/S0014-2999(97)01108-4, PII S0014299997011084
    • Yokoshiki H, Katsube Y, Sunagawa M, et al. Levosimendan, a novel Ca sensitizer, activates the glibenclamide sensitive K channel in rat arterial myocytes. Eu J Pharmacol 1997;333:249-259. (Pubitemid 27387398)
    • (1997) European Journal of Pharmacology , vol.333 , Issue.2-3 , pp. 249-259
    • Yokoshiki, H.1    Katsube, Y.2    Sunagawa, M.3    Sperelakis, N.4
  • 20
    • 0343049171 scopus 로고    scopus 로고
    • Comparison of the vasorelaxing effect of cormakalim and the new inodilator, Levosimendan, in human isolated portal vein
    • Pataricza J, Hohn J, Petri A, et al. Comparison of the vasorelaxing effect of cormakalim and the new inodilator, Levosimendan, in human isolated portal vein. J Pharm Pharmacol 2000;52:213-217.
    • (2000) J Pharm Pharmacol , vol.52 , pp. 213-217
    • Pataricza, J.1    Hohn, J.2    Petri, A.3
  • 21
    • 0035088001 scopus 로고    scopus 로고
    • Levosimendan increases diastolic coronary flow in isolated guinea pig heart by opening ATP-sensitive potassium channels
    • Kaheinen P, Pollesello P, Levijoki J, et al. Levosimendan increases diastolic coronary flow in isolated guinea pig heart by opening ATP-sensitive potassium channels. J Cardiovasc Pharmacol 2001;37:367-374.
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 367-374
    • Kaheinen, P.1    Pollesello, P.2    Levijoki, J.3
  • 22
    • 16344362711 scopus 로고    scopus 로고
    • Effects of intravenous Levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake
    • Michaels AD, McKeown B, Kostal M, et al. Effects of intravenous Levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake. Circulation 2005;111:1504-1509.
    • (2005) Circulation , vol.111 , pp. 1504-1509
    • Michaels, A.D.1    McKeown, B.2    Kostal, M.3
  • 23
    • 25144460454 scopus 로고    scopus 로고
    • Cardioprotection: A new paradigm in the management of acute heart failure syndromes
    • Maytin M, Colucci WS. Cardioprotection: a new paradigm in the management of acute heart failure syndromes. Am J Cardiol 2005; 96(Suppl):26G-31G.
    • (2005) Am J Cardiol , vol.96 , Issue.SUPPL.
    • Maytin, M.1    Colucci, W.S.2
  • 24
    • 0034669441 scopus 로고    scopus 로고
    • Hemodynamic and neurohumoral effects of continuous infusion of Levosimendan in patients with congestive heart failure
    • Nieminen MS, Akkila J, Hesenfuss G, et al. Hemodynamic and neurohumoral effects of continuous infusion of Levosimendan in patients with congestive heart failure. J Am Coll Cardiol 2000;36:1903-1912.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1903-1912
    • Nieminen, M.S.1    Akkila, J.2    Hesenfuss, G.3
  • 25
    • 0030226423 scopus 로고    scopus 로고
    • Basic mechanisms in heart failure: The cytokine hypothesis
    • Seta Y, Shan K, Bozkurt B, et al. Basic mechanisms in heart failure: the cytokine hypothesis. J Card Fail 1996;3:243-249.
    • (1996) J Card Fail , vol.3 , pp. 243-249
    • Seta, Y.1    Shan, K.2    Bozkurt, B.3
  • 26
    • 0032991345 scopus 로고    scopus 로고
    • New insights into the pathophysiological role for cytokines in heart failure
    • Sasayama S, Matsumori A, Kihara Y. New insights into the pathophysiological role for cytokines in heart failure. Cardiovasc Res 1999;42:557-564.
    • (1999) Cardiovasc Res , vol.42 , pp. 557-564
    • Sasayama, S.1    Matsumori, A.2    Kihara, Y.3
  • 27
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990; 323:236-241.
    • (1990) N Engl J Med , vol.323 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3
  • 28
    • 0029871896 scopus 로고    scopus 로고
    • Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
    • Torre-Amione G, Kapadia S, Benedict C, et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the studies of left ventricular dysfunction (SOLVD). J Am Coll Cardiol 1996;27:1201-1206.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 1201-1206
    • Torre-Amione, G.1    Kapadia, S.2    Benedict, C.3
  • 29
    • 0031977811 scopus 로고    scopus 로고
    • Interleukin-6 spill-over in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure
    • Tsutamoto T, Hisanaga T, Wada A, et al. Interleukin-6 spill-over in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 1998; 31:391-398.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 391-398
    • Tsutamoto, T.1    Hisanaga, T.2    Wada, A.3
  • 30
    • 0034883243 scopus 로고    scopus 로고
    • Activation of the cardiac interleukin-6 system in advanced heart failure
    • Plenz G, Song ZF, Tjan TDT, et al. Activation of the cardiac interleukin-6 system in advanced heart failure. Eur J Heart Fail 2001;3:415-421.
    • (2001) Eur J Heart Fail , vol.3 , pp. 415-421
    • Plenz, G.1    Song, Z.F.2    Tjan, T.D.T.3
  • 32
    • 23744462187 scopus 로고    scopus 로고
    • The Ca 2+ sensitizer Levosimendan improves oxidative damage, BNP and pro-inflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamine
    • Avgeropoulou C, Andeadou I, Sophia Markantonis-Kyroudis T, et al. The Ca 2+ sensitizer Levosimendan improves oxidative damage, BNP and pro-inflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamine. Eu J Heart Fail 2005;7: 82-87.
    • (2005) Eu J Heart Fail , vol.7 , pp. 82-87
    • Avgeropoulou, C.1    Andeadou, I.2    Sophia Markantonis-Kyroudis, T.3
  • 33
    • 14944360679 scopus 로고    scopus 로고
    • Levosimendan reduces plasma B type natriuretic peptide and interleukin 6, and improves central hemodynamic in severe heart failure patients
    • Kyrzopoulos S, Adamapoulos S, Parissis JT, et al. Levosimendan reduces plasma B type natriuretic peptide and interleukin 6, and improves central hemodynamic in severe heart failure patients. Int J Cardiol 2005;99:409-413.
    • (2005) Int J Cardiol , vol.99 , pp. 409-413
    • Kyrzopoulos, S.1    Adamapoulos, S.2    Parissis, J.T.3
  • 34
    • 0021194420 scopus 로고
    • Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
    • Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984;311: 819-823.
    • (1984) N Engl J Med , vol.311 , pp. 819-823
    • Cohn, J.N.1    Levine, T.B.2    Olivari, M.T.3
  • 35
    • 0028865418 scopus 로고
    • Adverse consequences of high sympathetic nervous activitiy in the failing human heart
    • Kaye DM, Lefkovits J, Jennings GL, et al. Adverse consequences of high sympathetic nervous activitiy in the failing human heart. J Am Coll Cardiol 1995; 26: 1257-1263.
    • (1995) J Am Coll Cardiol , vol.26 , pp. 1257-1263
    • Kaye, D.M.1    Lefkovits, J.2    Jennings, G.L.3
  • 36
    • 4544318680 scopus 로고    scopus 로고
    • Effect of baseline or changes in adrenergic activitiy on clinical outcomes in the beta blocker evaluation of survival trial
    • Bristow MR, Krause-Steinrauf H, Nuzzo R, et al. Effect of baseline or changes in adrenergic activitiy on clinical outcomes in the beta blocker evaluation of survival trial. Circulation 2004;110: 1437-1442.
    • (2004) Circulation , vol.110 , pp. 1437-1442
    • Bristow, M.R.1    Krause-Steinrauf, H.2    Nuzzo, R.3
  • 37
    • 0033600153 scopus 로고    scopus 로고
    • Effects of intravenous Levosimendan on plasma neurohormone levels in patients with heart failure: Relation to hemodynamic response
    • Nicklas JM, Monsur JC, Bleske BE. Effects of intravenous Levosimendan on plasma neurohormone levels in patients with heart failure: relation to hemodynamic response. Am J Cardiol 1999;83:112-115.
    • (1999) Am J Cardiol , vol.83 , pp. 112-115
    • Nicklas, J.M.1    Monsur, J.C.2    Bleske, B.E.3
  • 38
    • 0035137489 scopus 로고    scopus 로고
    • A rapid bedside test for B type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: A pilot study
    • Cheng V, Kazanagra R, Garcia A, et al. A rapid bedside test for B type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 2001;37:386-391.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 386-391
    • Cheng, V.1    Kazanagra, R.2    Garcia, A.3
  • 39
    • 28344446514 scopus 로고    scopus 로고
    • Short term effects of Levosimendan and prostaglandin E1 on hemodynamic parameters and B type natriuretic peptide levels in patients with decompensated chronic heart failure
    • Moertl D, Berger R, Huelsmann M, et al. Short term effects of Levosimendan and prostaglandin E1 on hemodynamic parameters and B type natriuretic peptide levels in patients with decompensated chronic heart failure. Eur J Heart Fail 2005;7:1156-1163.
    • (2005) Eur J Heart Fail , vol.7 , pp. 1156-1163
    • Moertl, D.1    Berger, R.2    Huelsmann, M.3
  • 40
    • 23044500417 scopus 로고    scopus 로고
    • Effects of Levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure
    • Parissis JT, Panou F, Farmakis D, et al. Effects of Levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure. Am J Cardiol 2005;96:423-426.
    • (2005) Am J Cardiol , vol.96 , pp. 423-426
    • Parissis, J.T.1    Panou, F.2    Farmakis, D.3
  • 41
    • 0031958567 scopus 로고    scopus 로고
    • Coronary vasorelaxant effect of Levosimendan, a new inodilator with calcium sensitizing properties
    • Gruhn N, Nielsen-Kudsk JE, Theilgaard S, et al. Coronary vasorelaxant effect of Levosimendan, a new inodilator with calcium sensitizing properties. J Cardiovasc Pharmacol 1998;31:741-749.
    • (1998) J Cardiovasc Pharmacol , vol.31 , pp. 741-749
    • Gruhn, N.1    Nielsen-Kudsk, J.E.2    Theilgaard, S.3
  • 42
    • 0035088001 scopus 로고    scopus 로고
    • Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels
    • Kaheinen P, Pollesello P, Levijoki J, et al. Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels. J Cardiovasc Pharmacol 2001;37:367-374.
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 367-374
    • Kaheinen, P.1    Pollesello, P.2    Levijoki, J.3
  • 43
    • 0033696857 scopus 로고    scopus 로고
    • Myocardial efficiency during Levosimendan infusion in congestive heart failure
    • Ukkonen H, Sarastre M, Akkila J, et al. Myocardial efficiency during Levosimendan infusion in congestive heart failure. Clin Pharmacol Ther 2000;68:522-531.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 522-531
    • Ukkonen, H.1    Sarastre, M.2    Akkila, J.3
  • 44
    • 0037142946 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous Levosimendan compared with dobutamine in severe low output heart failure (the LIDO study): A randomized double-blind trial
    • Follath F, Cleland JG, Just H, et al. Efficacy and safety of intravenous Levosimendan compared with dobutamine in severe low output heart failure (the LIDO study): a randomized double-blind trial. Lancet 2002;360:196-202.
    • (2002) Lancet , vol.360 , pp. 196-202
    • Follath, F.1    Cleland, J.G.2    Just, H.3
  • 46
    • 0036137181 scopus 로고    scopus 로고
    • Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure
    • DOI 10.1177/0091270002042001005
    • Kivikko M, Antila S, Eha J, et al. Pharmacodynamics and safety of a new calcium sensitizer, Levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. J Clin Pharmacol 2002;42:43-51. (Pubitemid 34038369)
    • (2002) Journal of Clinical Pharmacology , vol.42 , Issue.1 , pp. 43-51
    • Kivikko, M.1    Antila, S.2    Eha, J.3    Lehtonen, L.4    Pentikainen, P.J.5
  • 47
    • 3142584905 scopus 로고    scopus 로고
    • The effect of a calcium sensitizer or an inotrope or none in chronic low output decompensated heart failure: Results from the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO)
    • Abstract
    • Zairis MN, Apostolatos C, Anastasiadis P. The effect of a calcium sensitizer or an inotrope or none in chronic low output decompensated heart failure: results from the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO). (Abstract). J Am Coll Cardiol 2004; 43: (Suppl 1):206A-207A.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL. 1
    • Zairis, M.N.1    Apostolatos, C.2    Anastasiadis, P.3
  • 48
    • 2942619175 scopus 로고    scopus 로고
    • Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure: Results with Levosimendan in the REVIVE-1 study
    • Abstract
    • Packer M, Colucci WS, Fisher L. Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure: results with Levosimendan in the REVIVE-1 study. (Abstract). J Card Fail 2003;9:S61.
    • (2003) J Card Fail , vol.9
    • Packer, M.1    Colucci, W.S.2    Fisher, L.3
  • 50
    • 17644414685 scopus 로고    scopus 로고
    • Study design of a mortality trial with intravenous Levosimendan (the SURVIVE study) in patients with acutely decompensated heart failure
    • Abstract
    • Mebazaa A, Cohen-Solal A, Kleber F. Study design of a mortality trial with intravenous Levosimendan (the SURVIVE study) in patients with acutely decompensated heart failure. (Abstract). Critical Care 2004;8:(Suppl 1):87.
    • (2004) Critical Care , vol.8 , Issue.SUPPL. 1 , pp. 87
    • Mebazaa, A.1    Cohen-Solal, A.2    Kleber, F.3
  • 52
    • 0031976338 scopus 로고    scopus 로고
    • Effects of a new calcium sensitizer, Levosimendan, on hemodynamics, coronary blood flow and myocardial substrate utilization early after CABG
    • Lilleberg J, Nieminem MS, AkkilaJ, et al. Effects of a new calcium sensitizer, Levosimendan, on hemodynamics, coronary blood flow and myocardial substrate utilization early after CABG. Eu Heart J 1998; 19:660-668.
    • (1998) Eu Heart J , vol.19 , pp. 660-668
    • Lilleberg, J.1    Nieminem, M.S.2    Akkila, J.3
  • 53
    • 4444321791 scopus 로고    scopus 로고
    • The use of the novel calcium sensitizer Levosimendan in critically ill patients
    • Plochl W, Rajek A. The use of the novel calcium sensitizer Levosimendan in critically ill patients. Anaesth Inensive Care 2004;32:471-475.
    • (2004) Anaesth Inensive Care , vol.32 , pp. 471-475
    • Plochl, W.1    Rajek, A.2
  • 54
    • 0032771929 scopus 로고    scopus 로고
    • Levosimendan enhances cardiac performance after cardiopulmonary bypass: A prospective, randomized placebo-controlled trial
    • Nijhawan N, Nicolosi A, Montgomery MW, et al. Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial. J Cardiovasc Pharmacol 1999;34:219-228.
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 219-228
    • Nijhawan, N.1    Nicolosi, A.2    Montgomery, M.W.3
  • 55
    • 9744258720 scopus 로고    scopus 로고
    • Levosimendan in off-pump coronary artery bypass: A four times masked controlled study
    • Barisin S, Husedzinovic I, Sonicki Z, et al. Levosimendan in off-pump coronary artery bypass: a four times masked controlled study. J Cardiovasc Pharmacol 2004;44:703-708.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 703-708
    • Barisin, S.1    Husedzinovic, I.2    Sonicki, Z.3
  • 57
    • 1342267272 scopus 로고    scopus 로고
    • Successful use of Levosimendan in a patient with peripartum cardiomyopathy
    • Benlolo S, Lefoll C, Katchatouryan V, et al. Successful use of Levosimendan in a patient with peripartum cardiomyopathy. Anaesth Analg 2004;98:822-824.
    • (2004) Anaesth Analg , vol.98 , pp. 822-824
    • Benlolo, S.1    Lefoll, C.2    Katchatouryan, V.3
  • 58
    • 25144486420 scopus 로고    scopus 로고
    • Levosimendan is safe and effective in patients with severe low cardiac output heart failure and critical hypotension.
    • Abstract
    • Franco F, Monteiro P, Correia J. Levosimendan is safe and effective in patients with severe low cardiac output heart failure and critical hypotension. (Abstract) J Am Coll Cardiol 2004;43:191A.
    • (2004) J Am Coll Cardiol , vol.43
    • Franco, F.1    Monteiro, P.2    Correia, J.3
  • 59
    • 33748063334 scopus 로고    scopus 로고
    • Efficacy of Levosimendan in shock
    • Abstract
    • McLean A, Huang S, Stewart D, et al. Efficacy of Levosimendan in shock. (Abstract) Crit Care 2004;6:83.
    • (2004) Crit Care , vol.6 , pp. 83
    • McLean, A.1    Huang, S.2    Stewart, D.3
  • 60
    • 33748060890 scopus 로고    scopus 로고
    • Hemodynamic and volumetric response to Levosimendan in critical care patients
    • Abstract
    • Turani F, Aurisicchio P, D'Ercole P. Hemodynamic and volumetric response to Levosimendan in critical care patients. (Abstract) Crit Care 2004;6:84.
    • (2004) Crit Care , vol.6 , pp. 84
    • Turani, F.1    Aurisicchio, P.2    D'Ercole, P.3
  • 61
    • 0345305787 scopus 로고    scopus 로고
    • Hemodynamic effects of a continuous infusion of Levosimendan in critically ill patients with cardiogénico shock requiring catecholamines
    • Delle Karth G, Buberl A, Geppert A, et al. Hemodynamic effects of a continuous infusion of Levosimendan in critically ill patients with cardiogénico shock requiring catecholamines. Acta Anaesth Scan 2003;47:1251-1256.
    • (2003) Acta Anaesth Scan , vol.47 , pp. 1251-1256
    • Delle Karth, G.1    Buberl, A.2    Geppert, A.3
  • 62
    • 0024405217 scopus 로고
    • The cardiovascular pathophysiology of sepsis
    • Parrillo JE. The cardiovascular pathophysiology of sepsis. Ann Rev Med 1989;40:469-485.
    • (1989) Ann Rev Med , vol.40 , pp. 469-485
    • Parrillo, J.E.1
  • 64
    • 65249171458 scopus 로고    scopus 로고
    • The consequences of cardiac autonomic dysfunction in multiple organ dysfunction syndrome
    • Vincent JL (ed) Heidelberg: Springer
    • Schmidt H, Muller-Werdan U, Werdan K. The consequences of cardiac autonomic dysfunction in multiple organ dysfunction syndrome. In: Vincent JL (ed) 2008 Yearbook of Intensive Care and Emergency Medicine. Heidelberg: Springer, 2008;p:55-64.
    • (2008) 2008 Yearbook of Intensive Care and Emergency Medicine , pp. 55-64
    • Schmidt, H.1    Muller-Werdan, U.2    Werdan, K.3
  • 66
    • 0028233207 scopus 로고
    • Pseudomonas sepsis does not cause more severe cardiovascular dysfunction in patients than non-pseudomonas sepsis
    • Pilz G, McGinn P, Boekstegers P, et al. Pseudomonas sepsis does not cause more severe cardiovascular dysfunction in patients than non-pseudomonas sepsis. Circ Shock 1994;42:174-182.
    • (1994) Circ Shock , vol.42 , pp. 174-182
    • Pilz, G.1    McGinn, P.2    Boekstegers, P.3
  • 67
    • 38349086961 scopus 로고    scopus 로고
    • Classification of the cardiomyopathies: A position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
    • Elliott P, Andersson B, Arbustini E, et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group On Myocardial and Pericardial Diseases. Eur Heart J 2008;29:270-276.
    • (2008) Eur Heart J , vol.29 , pp. 270-276
    • Elliott, P.1    Andersson, B.2    Arbustini, E.3
  • 68
    • 0035174034 scopus 로고    scopus 로고
    • Effects of Levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock
    • Oldner A, Konrad D, Weitzberg E, et al. Effects of Levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 2001;29:2185-2193.
    • (2001) Crit Care Med , vol.29 , pp. 2185-2193
    • Oldner, A.1    Konrad, D.2    Weitzberg, E.3
  • 69
    • 14944370251 scopus 로고    scopus 로고
    • Inotropic options for postresuscitation myocardial dysfunction
    • Gazmuri RJ, Kolarova JD, Ayoub IM. Inotropic options for postresuscitation myocardial dysfunction. Crit Care Med 2005;33:668-669.
    • (2005) Crit Care Med , vol.33 , pp. 668-669
    • Gazmuri, R.J.1    Kolarova, J.D.2    Ayoub, I.M.3
  • 71
    • 13444266490 scopus 로고    scopus 로고
    • Successful reversal of resistant hypodynamic septic shock with Levosimendan
    • Matejovic M, Krouzecky A, Radej J, et al. Successful reversal of resistant hypodynamic septic shock with Levosimendan. Acta Anaesthesiol Scand 2005;49:127.
    • (2005) Acta Anaesthesiol Scand , vol.49 , pp. 127
    • Matejovic, M.1    Krouzecky, A.2    Radej, J.3
  • 72
    • 0029975877 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and interleukin 1-beta are responsible for depression of in vitro myocardial cell contractility induced by serum from humans with septic shock
    • Kumar A, Thota V, Dee L, et al. Tumor necrosis factor-alpha and interleukin 1-beta are responsible for depression of in vitro myocardial cell contractility induced by serum from humans with septic shock. J Exp Med 1996;183:949-958.
    • (1996) J Exp Med , vol.183 , pp. 949-958
    • Kumar, A.1    Thota, V.2    Dee, L.3
  • 73
    • 0027483722 scopus 로고
    • Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in adult mammalian heart
    • Yokoyama T, Vaca L, Rossen RD, et al. Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in adult mammalian heart. J Clin Invest 1993;92:2303-2312.
    • (1993) J Clin Invest , vol.92 , pp. 2303-2312
    • Yokoyama, T.1    Vaca, L.2    Rossen, R.D.3
  • 74
    • 18844440155 scopus 로고    scopus 로고
    • 2+and contractility on isolated adult rabbit ventricular myocytes
    • 2+ and contractility on isolated adult rabbit ventricular myocytes. Am J Physiol 1996;271(Suppl 4):H 1499-1505 g.
    • (1996) Am J Physiol , vol.271 , Issue.SUPPL. 4
    • Goldhaber, J.I.1    Kim, K.H.2    Natterson, P.D.3
  • 75
    • 33744794589 scopus 로고    scopus 로고
    • Levosimendan protects against experimental endotoxemic acute renal failure
    • Zager RA, Johnson AC, Lund S, et al. Levosimendan protects against experimental endotoxemic acute renal failure. Am J Renal Physiol 2006;290:1453-1462.
    • (2006) Am J Renal Physiol , vol.290 , pp. 1453-1462
    • Zager, R.A.1    Johnson, A.C.2    Lund, S.3
  • 76
    • 23744462187 scopus 로고    scopus 로고
    • 2+ sensitizer Levosimendan improves oxidative damage, BNP and proinflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamina
    • 2+ sensitizer Levosimendan improves oxidative damage, BNP and proinflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamina. Eur J Heart Failure 2005;7:882-887.
    • (2005) Eur J Heart Failure , vol.7 , pp. 882-887
    • Avgeropolou, C.1    Andreadou, I.2    Markantonis-Kyroudis, S.3
  • 77
    • 0027388856 scopus 로고
    • Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: Association with myocardial hyporesponsiveness to catecholamines
    • Silverman HJ, Peneranda R, Orens JB, et al. Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: Association with myocardial hyporesponsiveness to catecholamines. Crit Care Med 1993;21:31-39.
    • (1993) Crit Care Med , vol.21 , pp. 31-39
    • Silverman, H.J.1    Peneranda, R.2    Orens, J.B.3
  • 78
    • 37549020378 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.
    • (2008) Crit Care Med , vol.36 , pp. 296-327
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3
  • 79
    • 0027172674 scopus 로고
    • The search for the ideal positive inotropic agent
    • Packer M. The search for the ideal positive inotropic agent. N Eng J Med 1993;329:201-202.
    • (1993) N Eng J Med , vol.329 , pp. 201-202
    • Packer, M.1
  • 80
    • 21044443575 scopus 로고    scopus 로고
    • Effects of Levosimendan on systemic and regional hemodynamics in septic myocardial depression
    • Morelli A, De Castro S, Teboul JL, et al. Effects of Levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 2005;31:638-644.
    • (2005) Intensive Care Med , vol.31 , pp. 638-644
    • Morelli, A.1    De Castro, S.2    Teboul, J.L.3
  • 81
    • 33747456675 scopus 로고    scopus 로고
    • Effects of Levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: A pilot study
    • Morelli A, Teboul JL, Maggiore S, et al. Effects of Levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: A pilot study. Crit Care Med 2006;34:2287-2293.
    • (2006) Crit Care Med , vol.34 , pp. 2287-2293
    • Morelli, A.1    Teboul, J.L.2    Maggiore, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.