Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy

Journal of Translational Medicine

Volumn 8, Issue , 2010, Pages

  Lin, Yu Chun ^a   Leu, Steve ^a   Sun, Cheuk Kwan ^a   Yen, Chia Hung ^b   Kao, Ying Hsien ^c   Chang, Li Teh ^d   Tsai, Tzu Hsien ^a   Chua, Sarah ^a   Fu, Morgan ^a   Ko, Sheung Fat ^a   Wu, Chiung Jen ^a   Lee, Fan Yen ^a   Yip, Hon Kan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d MEIHO UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CD31 ANTIGEN; CD40 ANTIGEN; CONNEXIN 43; CYTOCHROME C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 8; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; SILDENAFIL; STROMAL CELL DERIVED FACTOR 1ALPHA; PHOSPHODIESTERASE INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ADIPOSE TISSUE CELL; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE FIBROSIS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; ADIPOSE TISSUE; ANIMAL; BODY WEIGHT; CYTOLOGY; ECHOGRAPHY; IMMUNOHISTOCHEMISTRY; LEWIS RAT; MESENCHYMAL STEM CELL; METABOLISM; ORGAN SIZE; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ANIMALS; APOPTOSIS; BODY WEIGHT; CARDIOMYOPATHY, DILATED; CONNEXIN 43; CYTOCHROMES C; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELLS; ORGAN SIZE; OXIDATIVE STRESS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONES;

EID: 77956917569     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-8-88     Document Type: Article

References (37)

1. Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. Jama 1995, 273:1450-1456. 10.1001/jama.273.18.1450, 7654275.
2. Pitt B, Poole-Wilson PA, Segal R, Martinez FA, Dickstein K, Camm AJ, Konstam MA, Riegger G, Klinger GH, Neaton J, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial--the Losartan Heart Failure Survival Study ELITE II. Lancet 2000, 355:1582-1587. 10.1016/S0140-6736(00)02213-3, 10821361.
3. Solomon SD, Wang D, Finn P, Skali H, Zornoff L, McMurray JJ, Swedberg K, Yusuf S, Granger CB, Michelson EL, et al. Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation 2004, 110:2180-2183. 10.1161/01.CIR.0000144474.65922.AA, 15466644.
4. Frazier OH, Benedict CR, Radovancevic B, Bick RJ, Capek P, Springer WE, Macris MP, Delgado R, Buja LM. Improved left ventricular function after chronic left ventricular unloading. Ann Thorac Surg 1996, 62:675-681. discussion 681-672, 10.1016/S0003-4975(96)00437-7, 8783992.
5. Dandel M, Weng Y, Siniawski H, Potapov E, Lehmkuhl HB, Hetzer R. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation 2005, 112:I37-45. 10.1161/CIRCULATIONAHA.104.518167, 16159848.
6. Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, Lubsen J, Lutiger B, Metra M, Remme WJ, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 2003, 362:7-13. 10.1016/S0140-6736(03)13800-7, 12853193.
7. Di Lenarda A, Remme WJ, Charlesworth A, Cleland JG, Lutiger B, Metra M, Komajda M, Torp-Pedersen C, Scherhag A, Swedberg K, Poole-Wilson PA. Exchange of beta-blockers in heart failure patients. Experiences from the poststudy phase of COMET (the Carvedilol or Metoprolol European Trial). Eur J Heart Fail 2005, 7:640-649. 10.1016/j.ejheart.2004.09.010, 15921806.
8. Tomita S, Li RK, Weisel RD, Mickle DA, Kim EJ, Sakai T, Jia ZQ. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999, 100:II247-256.
9. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002, 106:1913-1918. 10.1161/01.CIR.0000034046.87607.1C, 12370212.
10. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, Herve P, Etievent JP, Kantelip JP. Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 2003, 108(Suppl 1):II253-258.
11. Dai W, Hale SL, Martin BJ, Kuang JQ, Dow JS, Wold LE, Kloner RA. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short-and long-term effects. Circulation 2005, 112:214-223. 10.1161/CIRCULATIONAHA.104.527937, 15998673.
12. Yip HK, Chang LT, Wu CJ, Sheu JJ, Youssef AA, Pei SN, Lee FY, Sun CK. Autologous bone marrow-derived mononuclear cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction. Circ J 2008, 72:1336-1345. 10.1253/circj.72.1336, 18654023.
13. Sun CK, Chang LT, Sheu JJ, Chiang CH, Lee FY, Wu CJ, Chua S, Fu M, Yip HK. Bone marrow-derived mononuclear cell therapy alleviates left ventricular remodeling and improves heart function in rat-dilated cardiomyopathy. Crit Care Med 2009, 37:1197-1205. 10.1097/CCM.0b013e31819c0667, 19242323.
14. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996, 8:47-52.
15. Goldenberg MM. Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction. Clin Ther 1998, 20:1033-1048. 10.1016/S0149-2918(98)80103-3, 9916601.
16. Ahn HS, Foster M, Cable M, Pitts BJ, Sybertz EJ. Ca/CaM-stimulated and cGMP-specific phosphodiesterases in vascular and non-vascular tissues. Adv Exp Med Biol 1991, 308:191-197.
17. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, Maripov A, Mirrakhimov MM, Aldashev A, Wilkins MR. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 2001, 104:424-428. 10.1161/hc2901.093117, 11468204.
18. Shekerdemian LS, Ravn HB, Penny DJ. Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. Am J Respir Crit Care Med 2002, 165:1098-1102.
19. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kawamata M, Kato T, Okochi H, Ochiya T. IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells 2008, 26:2705-2712. 10.1634/stemcells.2008-0034, 18535155.
20. Behling A, Rohde LE, Colombo FC, Goldraich LA, Stein R, Clausell N. Effects of 5'-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: a double-blind, placebo-controlled clinical trial. J Card Fail 2008, 14:189-197. 10.1016/j.cardfail.2007.11.006, 18381181.
21. Muranaka H, Marui A, Tsukashita M, Wang J, Nakano J, Ikeda T, Sakata R. Prolonged mechanical unloading preserves myocardial contractility but impairs relaxation in rat heart of dilated cardiomyopathy accompanied by myocardial stiffness and apoptosis. J Thorac Cardiovasc Surg 2010,
22. Yen CH, Leu S, Lin YC, Kao YH, Chang LT, Chua S, Fu M, Wu CJ, Sun CK, Yip HK. Sildenafil Limits Monocrotaline-Induced Pulmonary Hypertension in Rats through Suppression of Pulmonary Vascular Remodeling. J Cardiovasc Pharmacol 2010, 55:574-584. 10.1097/FJC.0b013e3181d9f5f4, 20224427.
23. Kocher AA, Schuster MD, Bonaros N, Lietz K, Xiang G, Martens TP, Kurlansky PA, Sondermeijer H, Witkowski P, Boyle A, et al. Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines. J Mol Cell Cardiol 2006, 40:455-464. 10.1016/j.yjmcc.2005.11.013, 16438981.
24. Nagaya N, Kangawa K, Itoh T, Iwase T, Murakami S, Miyahara Y, Fujii T, Uematsu M, Ohgushi H, Yamagishi M, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005, 112:1128-1135. 10.1161/CIRCULATIONAHA.104.500447, 16103243.
25. Blanco I, Gimeno E, Munoz PA, Pizarro S, Gistau C, Rodriguez-Roisin R, Roca J, Barbera JA. Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Am J Respir Crit Care Med 181:270-278. 10.1164/rccm.200907-0988OC, 19875684.
26. Schermuly RT, Kreisselmeier KP, Ghofrani HA, Yilmaz H, Butrous G, Ermert L, Ermert M, Weissmann N, Rose F, Guenther A, et al. Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med 2004, 169:39-45. 10.1164/rccm.200302-282OC, 12958054.
27. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003, 361:47-49. 10.1016/S0140-6736(03)12111-3, 12517468.
28. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005, 23:879-894. 10.1634/stemcells.2004-0342, 15888687.
29. Kee HJ, Sohn IS, Nam KI, Park JE, Qian YR, Yin Z, Ahn Y, Jeong MH, Bang YJ, Kim N, et al. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation 2006, 113:51-59. 10.1161/CIRCULATIONAHA.105.559724, 16380549.
30. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 2002, 53:31-47. 10.1016/S0008-6363(01)00434-5, 11744011.
31. Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res 2008, 58:88-111. 10.1016/j.phrs.2008.06.007, 2642482, 18620057.
32. Garrido AM, Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 2009, 302:148-158. 10.1016/j.mce.2008.11.003, 2835147, 19059306.
33. Thum T, Bauersachs J, Poole-Wilson PA, Volk HD, Anker SD. The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. J Am Coll Cardiol 2005, 46:1799-1802. 10.1016/j.jacc.2005.07.053, 16286162.
34. Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R. Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 2003, 551:491-501. 10.1113/jphysiol.2003.045104, 2343221, 12824444.
35. Suwa M, Nakano H, Kumagai S. Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. J Appl Physiol 2003, 95:960-968.
36. Kirchhoff S, Nelles E, Hagendorff A, Kruger O, Traub O, Willecke K. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol 1998, 8:299-302. 10.1016/S0960-9822(98)70114-9, 9501070.
37. Peters NS, Green CR, Poole-Wilson PA, Severs NJ. Cardiac arrhythmogenesis and the gap junction. J Mol Cell Cardiol 1995, 27:37-44. 10.1016/S0022-2828(08)80005-3, 7760358.