Time course of action and pharmacokinetics of ropivacaine in adult and elderly patients following combined lumbar plexus-sciatic nerve block

International Journal of Clinical Pharmacology and Therapeutics

Volumn 48, Issue 9, 2010, Pages 608-613

  Xiao, J ^a   Cai, M H ^a   Wang, X R ^a   He, P ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Combined lumbar plexus sciatic nerve block; Pharmacokinetics; Ropivacaine

Indexed keywords

FENTANYL; MIDAZOLAM; ROPIVACAINE; AMIDE; LOCAL ANESTHETIC AGENT;

ABSENCE OF SIDE EFFECTS; ADULT; AGE; AGED; ANESTHESIA INDUCTION; ANESTHETIC RECOVERY; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LOCAL ANESTHESIA; LUMBOSACRAL PLEXUS; MALE; MAXIMUM PLASMA CONCENTRATION; NERVE BLOCK; NERVE STIMULATION; OPERATION DURATION; ORTHOPEDIC SURGERY; SCIATIC NERVE; TIME TO MAXIMUM PLASMA CONCENTRATION; MIDDLE AGED; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AMIDES; ANESTHETICS, LOCAL; FEMALE; HUMANS; LUMBOSACRAL PLEXUS; MALE; MIDDLE AGED; NERVE BLOCK; SCIATIC NERVE;

EID: 77956916755     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP48608     Document Type: Article

References (25)

1. Simon MJG, Veering BT, Stienstra R, van Kleef JW, Burm AG. The effects of age on neural blockade and hemodynamic changes after epidural anesthesia with ropivacaine. Anesth Analg. 2002; 94: 1325-1330.
2. Simon MJG, Veering BT, Stienstra R, van Kleef JW, Burm AG. Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration. Br J Anaesth. 2004; 93: 512-520. (Pubitemid 39359880)
3. Simon MJG, Veering BT, Vletter AA, Stienstra R, van Kleef JW, Burm AG. The effect of age on the systemic absorption and systemic disposition of ropivacaine after epidural administration. Anesth Analg. 2006; 102: 276-282.
4. Graf BM, Abraham I, Eberbach N, Kunst G, Stowe DF, Martin E. Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties. Anesthesiology. 2002; 96: 1427-1434.
5. Dhir S, Ganapathy S, Lindsay P, Athwal GS. Ropivacaine neurotoxicity at clinical doses in interscalene brachial plexus block. Can J Anaesth. 2007; 54: 912-916.
6. Lopez-Soriano F, Rivas F, Lajarin B. Accidental administration of epidural remifentanil and intravenous ropivacaine. Farm Hosp. 2007; 31: 131-132.
7. Al-Nasser B. Toxic effects of epidural analgesia with ropivacaine 0.2% in a diabetic patient. J Clin Anesth. 2004; 16: 220-223.
8. Gnaho A, Eyrieux S, Gentili M. Cardiac arrest during an ultrasound-guided sciatic nerve block combined with nerve stimulation. Reg Anesth Pain Med. 2009; 34: 278.
9. Awad IT, Duggan EM. Posterior lumbar plexus block: anatomy, approaches, and techniques. Reg Anesth Pain Med. 2005; 30: 143-149.
10. Dilger JA. Lower extremity nerve blocks. Anesthesiol Clin North America. 2000; 18: 319-340.
11. Rifai N, Hsin O, Hope T, Sakamoto M. Simultaneous measurement of plasma ropivacaine and bupivacaine concentrations by HPLC with UV detection. Ther Drug Monit. 2001; 23: 182-186.
12. Vanterpool S, Steele SM, Nielsen KC, Tucker M, Klein SM. Combined lumbar-plexus and sciaticnerve blocks: an analysis of plasma ropivacaine concentrations. Reg Anesth Pain Med. 2006; 31: 417-421.
13. de Leeuw MA, Bet PM, Wilhelm AJ, Vos RM, Hoeksema M, de Lange JJ, Zuurmond WW, Perez RS. Total plasma concentrations of bupivacaine, levobupivacaine and ropivacaine after combined psoas compartment-sciatic nerve block. Eur J Anaesthesiol. 2009; 26: 1083-1085.
14. Markham A, Faulds D. Ropivacaine: a review of its pharmacology and therapeutic use in regional anaesthesia. Drugs. 1996; 52: 429-449. (Pubitemid 26293866)
15. Veering BT, Burm AG, Vletter AA, van den Heuvel RP, Onkenhout W, Spierdijk J. The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration. Clin Pharmacokinet. 1992; 22: 75-84.
16. Simon MJ, Veering BT, Stienstra R, van Kleef JW, Williams SG, McGuire GM, Burm AG. The systemic absorption and disposition of levobupivacaine 0.5% after epidural administration in surgical patients: a stable-isotope study. Eur J Anaesthesiol. 2004; 21: 460-470. (Pubitemid 38849720)
17. Tucker GT, Mather LE. Pharmacology of local anaesthetic agents. Pharmacokinetics of local anaesthetic agents. Br J Anaesth. 1975; 47: 213-224.
18. Xu HW, Zhang L, Cao W, Zhang X, Zhang WS. Clinical efficacy and pharmacokinetics of different concentrations of ropivacaine with the same dosage on blocking lumbar plexus with sciatic nerves. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009; 40: 495-498.
19. Rosenberg P, Veering B, Urmey W. Maximum recommended doses of local anesthetics: Amultifactorial concept. Reg Anesth Pain Med. 2004; 6: 564-575.
20. McClellan KJ, Faulds D. Ropivacaine: an update of its use in regional anaesthesia. Drugs. 2000; 60: 1065-1093.
21. Knudsen K, Beckman Suurkula M, Blomberg S, Sjovall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusion of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth. 1997; 78: 507-514.
22. Wulf H, Worthmann F, Behnke H, Bohle A S. Pharmacokinetics and pharmacodynamics of ropivacaine 2 mg/ml, 5 mg/ml, or 7.5mg/ml after ileoinguinal blockade for ileoinguinal hernia repair in adults. Anesth Analg. 1999; 89: 1471-1474.
23. Burm AG, Stienstra R, Brouwer RP, Emanuelsson BM, van Kleef JW. Epidural infusion of ropivacaine for postoperative analgesia after major orthopaedic surgery. Anesthesiology. 2000; 93: 395-403.
24. Corso OH, Morris RG, Hewett PJ, Karatassas A. Safety of 96-hour incision-site continuous infusion of ropivacaine for postoperative analgesia after bowel cancer resection. Ther Drug Monit. 2007; 29: 57-63.
25. Bianconi M, Ferraro L, Ricci R, Zanoli G, Antonelli T, Giulia B, Guberti A, Massari L. The pharmacokinetics and efficacy of ropivacaine continuous wound instillation after spine fusion surgery. Anesth Analg. 2004; 98: 166-172.