Alternative splicing of genes during neuronal differentiation of NT2 pluripotential human embryonal carcinoma cells

FEBS Letters

Volumn 584, Issue 18, 2010, Pages 4041-4047

  Wakamatsu, Ai ^a   Imai, Jun ichi ^b   Watanabe, Shinya ^b   Isogai, Takao ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c Reverse Proteomics Research Institute   (Japan)

Author keywords

Alternative splicing; Expression profile; MRNA diversity; Multiple protein coding transcript; Neuronal differentiation; Transcription factor

Indexed keywords

DNA; MESSENGER RNA; RETINOIC ACID; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA MICROARRAY; EMBRYONAL CARCINOMA STEM CELL; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NERVE CELL DIFFERENTIATION; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; TUMOR CELL LINE;

ALTERNATIVE SPLICING; CELL LINE, TUMOR; GENE EXPRESSION; HUMANS; NEUROGENESIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLURIPOTENT STEM CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRETINOIN;

EID: 77956898279     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.08.024     Document Type: Article

References (30)

1. Lander E.S., et al. Initial sequencing and analysis of the human genome. Nature 2001, 409:860-921.
2. Wang E.T., et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008, 456:470-476.
3. Stamm S. Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome. Hum. Mol. Genet. 2002, 11:2409-2416.
4. Li Q., et al. Neuronal regulation of alternative pre-mRNA splicing. Nat. Rev. Neurosci. 2007, 8:819-831.
5. Boutz P.L., et al. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev. 2007, 21:1636-1652.
6. Ule J., et al. Nova regulates brain-specific splicing to shape the synapse. Nat. Genet. 2005, 37:844-852.
7. Licatalosi D.D., et al. HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature 2008, 456:464-469.
8. Ota T., et al. Complete sequencing and characterization of 21, 243 full-length human cDNAs. Nat. Genet. 2004, 36:40-45.
9. Otsuki T., et al. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005, 12:117-126.
10. Kimura K., et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 2006, 16:55-65.
11. Wakamatsu A., et al. Identification and functional analyses of 11, 769 full-length human cDNAs focused on alternative splicing. DNA Res. 2009, 16:371-383.
12. Andrews P.W. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 1984, 103:285-293.
13. Miura A., et al. Differential responses of normal human coronary artery endothelial cells against multiple cytokines comparatively assessed by gene expression profiles. FEBS Lett. 2006, 580:6871-6879.
14. Tollervey D. Molecular biology: RNA lost in translation. Nature 2006, 440:425-426.
15. Houldsworth J., et al. Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells. Cell Growth Differ. 2002, 13:257-264.
16. Balmer J.E., Blomhoff R. Gene expression regulation by retinoic acid. J. Lipid Res. 2002, 43:1773-1808.
17. Levy E., et al. Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein. Eur. J. Biochem. 1987, 166:71-77.
18. Rossignol M., et al. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. Genomics 2000, 70:211-222.
19. Dehmelt L., Halpain S. The MAP2/Tau family of microtubule-associated proteins. Genome Biol. 2005, 6:204.
20. Pavel M.E., et al. Adrenomedullin is a novel marker of tumor progression in neuroendocrine carcinomas. Horm. Metab. Res. 2006, 38:112-118.
21. Landry J.R., et al. Complex controls: the role of alternative promoters in mammalian genomes. Trends Genet. 2003, 19:640-648.
22. Zhang T., et al. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Genome Res. 2004, 14:79-89.
23. Hirano M., et al. EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J. Cell Biol. 2008, 182:1217-1230.
24. Yamamoto S., et al. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell. 2008, 15:23-36.
25. Sato N., et al. Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2. J. Biol. Chem. 2001, 276:2108-2114.
26. Laitem C., et al. Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51. Oncogene 2009, 28:2087-2099.
27. Kim J., et al. Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). Genomics 2000, 64:114-118.
28. Kohda T., et al. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells 2001, 6:237-247.
29. Atlasi Y., et al. OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. Stem Cells 2008, 26:3068-3074.
30. Geretti E., Klagsbrun M. Neuropilins: novel targets for anti-angiogenesis therapies. Cell. Adh Migr. 2007, 1:56-61.