메뉴 건너뛰기




Volumn 246, Issue 3, 2010, Pages 154-162

Pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice after subchronic exposure to ethanol

Author keywords

Alcoholic pancreatitis; Apoptosis; Deer mice; ER stress; Fatty acid ethyl esters

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; CATHEPSIN B; FATTY ACID ESTER; GLUCOSE REGULATED PROTEIN 78; TRIACYLGLYCEROL LIPASE; TRYPSINOGEN ACTIVATION PEPTIDE;

EID: 77956881587     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.05.002     Document Type: Article
Times cited : (29)

References (61)
  • 1
    • 0015830528 scopus 로고
    • Inhibition by nicotinic acid of hepatic steatosis and alcohol dehydrogenase in ethanol-treated rats
    • Baker H., Luisada-Opper A., Sorrell M.F., Thomson A.D., Frank O. Inhibition by nicotinic acid of hepatic steatosis and alcohol dehydrogenase in ethanol-treated rats. Exp. Mol. Pathol. 1973, 19:106-112.
    • (1973) Exp. Mol. Pathol. , vol.19 , pp. 106-112
    • Baker, H.1    Luisada-Opper, A.2    Sorrell, M.F.3    Thomson, A.D.4    Frank, O.5
  • 2
    • 33751253098 scopus 로고    scopus 로고
    • Metabolic basis of ethanol-induced hepatic and pancreatic injury in hepatic alcohol dehydrogenase deficient deer mice
    • Bhopale K.K., Wu H., Boor P.J., Popov V.L., Ansari G.A., Kaphalia B.S. Metabolic basis of ethanol-induced hepatic and pancreatic injury in hepatic alcohol dehydrogenase deficient deer mice. Alcohol 2006, 39:179-188.
    • (2006) Alcohol , vol.39 , pp. 179-188
    • Bhopale, K.K.1    Wu, H.2    Boor, P.J.3    Popov, V.L.4    Ansari, G.A.5    Kaphalia, B.S.6
  • 3
    • 0018873918 scopus 로고
    • Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase
    • Burnett K.G., Felder M.R. Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase. Biochem. Pharmacol. 1980, 29:125-130.
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 125-130
    • Burnett, K.G.1    Felder, M.R.2
  • 4
    • 1242352563 scopus 로고    scopus 로고
    • Does acute alcoholic pancreatitis exists with preexisting chronic pancreatitis?
    • Brunner R., Xie J., Bank S. Does acute alcoholic pancreatitis exists with preexisting chronic pancreatitis?. J. Clin. Gastroenterol. 2004, 38:201-202.
    • (2004) J. Clin. Gastroenterol. , vol.38 , pp. 201-202
    • Brunner, R.1    Xie, J.2    Bank, S.3
  • 5
    • 77249150883 scopus 로고    scopus 로고
    • TGF-β enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I
    • Ciuclan L., Ehnert S., Iikavets I., et al. TGF-β enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J. Hepatol. 2010, 52:407-416.
    • (2010) J. Hepatol. , vol.52 , pp. 407-416
    • Ciuclan, L.1    Ehnert, S.2    Iikavets, I.3
  • 8
    • 0033546155 scopus 로고    scopus 로고
    • Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid
    • Deltour L., Foglio M.H., Duester G. Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J. Biol. Chem. 1999, 274:16796-16801.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16796-16801
    • Deltour, L.1    Foglio, M.H.2    Duester, G.3
  • 9
    • 0027302436 scopus 로고
    • Dehydrogenase-dependent metabolism of alcohols in gastric mucosa of deer mice lacking hepatic alcohol dehydrogenase
    • Ekstrom G., Cronholm T., Norsten-Hoog C., Ingelman-Sundberg M. Dehydrogenase-dependent metabolism of alcohols in gastric mucosa of deer mice lacking hepatic alcohol dehydrogenase. Biochem. Pharmacol. 1993, 45:1989-1994.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 1989-1994
    • Ekstrom, G.1    Cronholm, T.2    Norsten-Hoog, C.3    Ingelman-Sundberg, M.4
  • 10
    • 33644863941 scopus 로고    scopus 로고
    • Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis?
    • Fortunato F., Deng X., Gates L.K., et al. Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis?. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G232-241.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290
    • Fortunato, F.1    Deng, X.2    Gates, L.K.3
  • 11
    • 0036142305 scopus 로고    scopus 로고
    • Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats
    • Gukovskaya A.S., Mouria M., Gukovsky I., et al. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology 2002, 122:106-118.
    • (2002) Gastroenterology , vol.122 , pp. 106-118
    • Gukovskaya, A.S.1    Mouria, M.2    Gukovsky, I.3
  • 12
    • 0027278594 scopus 로고
    • Fatty acid ethyl esters increase rat pancreatic lysosomal fragility
    • Haber P.S., Wilson J.S., Apte M.V., Pirola R.C. Fatty acid ethyl esters increase rat pancreatic lysosomal fragility. J. Lab. Clin. Med. 1993, 121:759-764.
    • (1993) J. Lab. Clin. Med. , vol.121 , pp. 759-764
    • Haber, P.S.1    Wilson, J.S.2    Apte, M.V.3    Pirola, R.C.4
  • 13
    • 0033795691 scopus 로고    scopus 로고
    • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    • Halangk W., Lerch M.M., Brandt-Nedelev B., et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J. Clin. Invest. 2000, 106:773-781.
    • (2000) J. Clin. Invest. , vol.106 , pp. 773-781
    • Halangk, W.1    Lerch, M.M.2    Brandt-Nedelev, B.3
  • 15
    • 67650513305 scopus 로고    scopus 로고
    • Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation
    • Ji B., Gaiser S., Chen X., Ernst S.A., Logsdon C.D. Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation. J. Biol. Chem. 2009, 284:17488-17498.
    • (2009) J. Biol. Chem. , vol.284 , pp. 17488-17498
    • Ji, B.1    Gaiser, S.2    Chen, X.3    Ernst, S.A.4    Logsdon, C.D.5
  • 16
    • 84905614103 scopus 로고    scopus 로고
    • in press. Pancreatic Toxicology. In Encyclopedia of Environmental Health, Elsevier.
    • Kaphalia, B.S., in press. Pancreatic Toxicology. In Encyclopedia of Environmental Health, Elsevier.
    • Kaphalia, B.S.1
  • 17
    • 0035757622 scopus 로고    scopus 로고
    • Fatty acid ethyl esters and ethanol-induced pancreatitis
    • Online Pub, OL173-179
    • Kaphalia B.S., Ansari G.A. Fatty acid ethyl esters and ethanol-induced pancreatitis. Cell. Mol. Biol. (Noisy-le-grand) 2001, 47. Online Pub, OL173-179.
    • (2001) Cell. Mol. Biol. (Noisy-le-grand) , vol.47
    • Kaphalia, B.S.1    Ansari, G.A.2
  • 18
    • 0346025623 scopus 로고    scopus 로고
    • Purification and characterization of rat pancreatic fatty acid ethyl ester synthase and its structural and functional relationship to pancreatic cholesterol esterase
    • Kaphalia B.S., Ansari G.A. Purification and characterization of rat pancreatic fatty acid ethyl ester synthase and its structural and functional relationship to pancreatic cholesterol esterase. J. Biochem. Mol. Toxicol. 2003, 17:338-345.
    • (2003) J. Biochem. Mol. Toxicol. , vol.17 , pp. 338-345
    • Kaphalia, B.S.1    Ansari, G.A.2
  • 20
    • 14344256756 scopus 로고    scopus 로고
    • Fatty acid ethyl esters: markers of alcohol abuse and alcoholism
    • Kaphalia B.S., Cai P., Khan M.F., Okorodudu A.O., Ansari G.A. Fatty acid ethyl esters: markers of alcohol abuse and alcoholism. Alcohol 2004, 34:151-158.
    • (2004) Alcohol , vol.34 , pp. 151-158
    • Kaphalia, B.S.1    Cai, P.2    Khan, M.F.3    Okorodudu, A.O.4    Ansari, G.A.5
  • 21
    • 33747615232 scopus 로고    scopus 로고
    • Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum
    • Kaplowitz N., Ji C. Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. J. Gastroenterol. Hepatol. 2006, 21(Suppl 3):S7-9.
    • (2006) J. Gastroenterol. Hepatol. , vol.21 , Issue.SUPPL 3
    • Kaplowitz, N.1    Ji, C.2
  • 22
    • 0021899770 scopus 로고
    • Various causes of decreased aldehyde dehydrogenase activity in the rat liver and blood in chronic alcoholic intoxication
    • Kershengol'ts B.M., Alekseev V.G., Gavrilova E.M., Li N.G. Various causes of decreased aldehyde dehydrogenase activity in the rat liver and blood in chronic alcoholic intoxication. Vopr. Med. Khim. 1985, 31:47-51.
    • (1985) Vopr. Med. Khim. , vol.31 , pp. 47-51
    • Kershengol'ts, B.M.1    Alekseev, V.G.2    Gavrilova, E.M.3    Li, N.G.4
  • 23
    • 0029162726 scopus 로고
    • The effect of chronic alcohol administration on cerulein-induced pancreatitis
    • Korsten M.A., Haber P.S., Wilson J.S., Lieber C.S. The effect of chronic alcohol administration on cerulein-induced pancreatitis. Int. J. Pancreatol. 1995, 18:25-31.
    • (1995) Int. J. Pancreatol. , vol.18 , pp. 25-31
    • Korsten, M.A.1    Haber, P.S.2    Wilson, J.S.3    Lieber, C.S.4
  • 24
    • 34447515863 scopus 로고    scopus 로고
    • Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells
    • Kubisch C.H., Logsdon C.D. Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 292:G1804-812.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.292
    • Kubisch, C.H.1    Logsdon, C.D.2
  • 25
    • 0037077262 scopus 로고    scopus 로고
    • Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis
    • Kukor Z., Mayerle J., Kruger B., Toth M., Steed P.M., Halangk W., et al. Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. J. Biol. Chem. 2002, 277:21389-21396.
    • (2002) J. Biol. Chem. , vol.277 , pp. 21389-21396
    • Kukor, Z.1    Mayerle, J.2    Kruger, B.3    Toth, M.4    Steed, P.M.5    Halangk, W.6
  • 26
    • 0020573718 scopus 로고
    • Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol
    • Lange L.G., Sobel B.E. Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J. Clin. Invest. 1983, 72:724-731.
    • (1983) J. Clin. Invest. , vol.72 , pp. 724-731
    • Lange, L.G.1    Sobel, B.E.2
  • 28
    • 0022634648 scopus 로고
    • Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse
    • Laposata E.A., Lange L.G. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 1986, 231:497-499.
    • (1986) Science , vol.231 , pp. 497-499
    • Laposata, E.A.1    Lange, L.G.2
  • 29
    • 0030053078 scopus 로고    scopus 로고
    • Effects of prolonged ethanol intake and malnutrition on rat pancreas
    • Lopez J.M., Bombi J.A., Valderrama R., et al. Effects of prolonged ethanol intake and malnutrition on rat pancreas. Gut 1996, 38:285-292.
    • (1996) Gut , vol.38 , pp. 285-292
    • Lopez, J.M.1    Bombi, J.A.2    Valderrama, R.3
  • 31
    • 0026334432 scopus 로고
    • Ethanol-induced fatty acid ethyl ester formation in vivo and in vitro in rat lung
    • Manautou J.E., Carlson G.P. Ethanol-induced fatty acid ethyl ester formation in vivo and in vitro in rat lung. Toxicology 1991, 70:303-312.
    • (1991) Toxicology , vol.70 , pp. 303-312
    • Manautou, J.E.1    Carlson, G.P.2
  • 32
    • 0016793479 scopus 로고
    • Endogenous ethanol production and hepatic disease following jejunoileal bypass for morbid obesity
    • Mezey E., Imbembo A.L., Potter J.J., Rent K.C., Lombardo R.L., Hot P.R. Endogenous ethanol production and hepatic disease following jejunoileal bypass for morbid obesity. Am. J. Clin. Nutr. 1975, 28:1277-1283.
    • (1975) Am. J. Clin. Nutr. , vol.28 , pp. 1277-1283
    • Mezey, E.1    Imbembo, A.L.2    Potter, J.J.3    Rent, K.C.4    Lombardo, R.L.5    Hot, P.R.6
  • 33
    • 6944222632 scopus 로고    scopus 로고
    • Severe chronic pancreatitis and severe liver cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholics
    • Nakamura Y., Kobayashi Y., Ishikawa A., Maruyama K., Higuchi S. Severe chronic pancreatitis and severe liver cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholics. J. Gastroenterol. 2004, 39:879-887.
    • (2004) J. Gastroenterol. , vol.39 , pp. 879-887
    • Nakamura, Y.1    Kobayashi, Y.2    Ishikawa, A.3    Maruyama, K.4    Higuchi, S.5
  • 34
    • 0024560350 scopus 로고
    • Dehydrogenase-dependent ethanol metabolism in deer mice (Peromyscus maniculatus) lacking cytosolic alcohol dehydrogenase. Reversibility and isotope effects in vivo and in subcellular fractions
    • Norsten C., Cronholm T., Ekstrom G., Handler J.A., Thurman R.G., Ingelman-Sundberg M. Dehydrogenase-dependent ethanol metabolism in deer mice (Peromyscus maniculatus) lacking cytosolic alcohol dehydrogenase. Reversibility and isotope effects in vivo and in subcellular fractions. J. Biol. Chem. 1989, 264:5593-5597.
    • (1989) J. Biol. Chem. , vol.264 , pp. 5593-5597
    • Norsten, C.1    Cronholm, T.2    Ekstrom, G.3    Handler, J.A.4    Thurman, R.G.5    Ingelman-Sundberg, M.6
  • 35
    • 0020536806 scopus 로고
    • Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics
    • Nuutinen H., Lindros K.O., Salaspuro M. Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics. Alcohol. Clin. Exp. Res. 1983, 7:163-168.
    • (1983) Alcohol. Clin. Exp. Res. , vol.7 , pp. 163-168
    • Nuutinen, H.1    Lindros, K.O.2    Salaspuro, M.3
  • 36
    • 0021964596 scopus 로고
    • Aldehyde dehydrogenase in alcoholic subjects
    • Palmer K.R., Jenkins W.J. Aldehyde dehydrogenase in alcoholic subjects. Hepatology 1985, 5:260-263.
    • (1985) Hepatology , vol.5 , pp. 260-263
    • Palmer, K.R.1    Jenkins, W.J.2
  • 37
    • 34447635393 scopus 로고    scopus 로고
    • Pathobiology of alcoholic pancreatitis
    • Pandol S.J., Raraty M. Pathobiology of alcoholic pancreatitis. Pancreatology 2007, 7:105-114.
    • (2007) Pancreatology , vol.7 , pp. 105-114
    • Pandol, S.J.1    Raraty, M.2
  • 38
    • 0024335496 scopus 로고
    • Influence of liver disease on hepatic alcohol and aldehyde dehydrogenases
    • Panes J., Soler X., Pares A., et al. Influence of liver disease on hepatic alcohol and aldehyde dehydrogenases. Gastroenterology 1989, 97:708-714.
    • (1989) Gastroenterology , vol.97 , pp. 708-714
    • Panes, J.1    Soler, X.2    Pares, A.3
  • 39
    • 0027529054 scopus 로고
    • Determinants of ethanol and acetaldehyde metabolism in chronic alcoholics
    • Panes J., Caballeria J., Guitart R., et al. Determinants of ethanol and acetaldehyde metabolism in chronic alcoholics. Alcohol. Clin. Exp. Res. 1993, 17:48-53.
    • (1993) Alcohol. Clin. Exp. Res. , vol.17 , pp. 48-53
    • Panes, J.1    Caballeria, J.2    Guitart, R.3
  • 41
    • 0035990311 scopus 로고    scopus 로고
    • Pancreatic cholesterol esterase, ES-10, and fatty acid ethyl ester synthase III gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats
    • Pfutzer R.H., Tadic S.D., Li H.S., et al. Pancreatic cholesterol esterase, ES-10, and fatty acid ethyl ester synthase III gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats. Pancreas 2002, 25:101-106.
    • (2002) Pancreas , vol.25 , pp. 101-106
    • Pfutzer, R.H.1    Tadic, S.D.2    Li, H.S.3
  • 42
    • 0038080911 scopus 로고    scopus 로고
    • Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation
    • Reddy R.K., Mao C., Baumeister P., Austin R.C., Kaufman R.J., Lee A.S. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J. Biol. Chem. 2003, 278:20915-20924.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20915-20924
    • Reddy, R.K.1    Mao, C.2    Baumeister, P.3    Austin, R.C.4    Kaufman, R.J.5    Lee, A.S.6
  • 44
    • 0022651240 scopus 로고
    • Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation
    • Rinderknecht H. Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation. Dig. Dis. Sci. 1986, 31:314-321.
    • (1986) Dig. Dis. Sci. , vol.31 , pp. 314-321
    • Rinderknecht, H.1
  • 45
    • 33749075739 scopus 로고
    • Enzymatic pathways of ethanol metabolism
    • Plenum Press, New York, E. Majchrowicz (Ed.)
    • Rognstad R., Grunnet N. Enzymatic pathways of ethanol metabolism. Biochemistry and Pharmacology of Ethanol 1979, 65-86. Plenum Press, New York. E. Majchrowicz (Ed.).
    • (1979) Biochemistry and Pharmacology of Ethanol , pp. 65-86
    • Rognstad, R.1    Grunnet, N.2
  • 46
    • 0036285492 scopus 로고    scopus 로고
    • Animal models in alcoholic pancreatitis-what can we learn
    • Schneider A., Whitcomb D.C., Singer M.V. Animal models in alcoholic pancreatitis-what can we learn. Pancreatology 2002, 2:189-203.
    • (2002) Pancreatology , vol.2 , pp. 189-203
    • Schneider, A.1    Whitcomb, D.C.2    Singer, M.V.3
  • 47
    • 0021746696 scopus 로고
    • In vivo inhibition of liver alcohol dehydrogenase by ethanol administration
    • Sharkawi M. In vivo inhibition of liver alcohol dehydrogenase by ethanol administration. Life Sci. 1984, 35:2353-2357.
    • (1984) Life Sci. , vol.35 , pp. 2353-2357
    • Sharkawi, M.1
  • 48
    • 0021348801 scopus 로고
    • Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deer mice lacking alcohol dehydrogenase (ADH)
    • Shigeta Y., Nomura F., Iida S., Leo M.A., Felder M.R., Lieber C.S. Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deer mice lacking alcohol dehydrogenase (ADH). Biochem. Pharmacol. 1984, 33:807-814.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 807-814
    • Shigeta, Y.1    Nomura, F.2    Iida, S.3    Leo, M.A.4    Felder, M.R.5    Lieber, C.S.6
  • 49
    • 0013970252 scopus 로고
    • Substrate inhibition effects in the liver alcohol dehydrogenase reaction
    • Shore J.D., Theorell H. Substrate inhibition effects in the liver alcohol dehydrogenase reaction. Arch. Biochem. Biophys. 1966, 117:375-380.
    • (1966) Arch. Biochem. Biophys. , vol.117 , pp. 375-380
    • Shore, J.D.1    Theorell, H.2
  • 50
    • 0025286583 scopus 로고
    • Effect of prolonged ethanol intake on pancreatic lipids in the rat pancreas
    • Simsek H., Singh M. Effect of prolonged ethanol intake on pancreatic lipids in the rat pancreas. Pancreas 1990, 5:401-407.
    • (1990) Pancreas , vol.5 , pp. 401-407
    • Simsek, H.1    Singh, M.2
  • 51
    • 0025231554 scopus 로고
    • Ethanol and the pancreas. Current status
    • Singh M., Simsek H. Ethanol and the pancreas. Current status. Gastroenterology 1990, 98:1051-1062.
    • (1990) Gastroenterology , vol.98 , pp. 1051-1062
    • Singh, M.1    Simsek, H.2
  • 52
    • 0019911683 scopus 로고
    • Role of hepatic acetaldehyde dehydrogenase in alcoholism: demonstration of persistent reduction of cytosolic activity in abstaining patients
    • Thomas M., Halsall S., Peters T.J. Role of hepatic acetaldehyde dehydrogenase in alcoholism: demonstration of persistent reduction of cytosolic activity in abstaining patients. Lancet 1982, 2:1057-1058.
    • (1982) Lancet , vol.2 , pp. 1057-1058
    • Thomas, M.1    Halsall, S.2    Peters, T.J.3
  • 53
    • 33646830314 scopus 로고    scopus 로고
    • Ethanol feeding alters death signaling in the pancreas
    • Wang Y.L., Hu R., Lugea A., et al. Ethanol feeding alters death signaling in the pancreas. Pancreas 2006, 32:351-359.
    • (2006) Pancreas , vol.32 , pp. 351-359
    • Wang, Y.L.1    Hu, R.2    Lugea, A.3
  • 54
    • 0030984694 scopus 로고    scopus 로고
    • Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol
    • Werner J., Laposata M., Fernandez-del Castillo C., et al. Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 1997, 113:286-294.
    • (1997) Gastroenterology , vol.113 , pp. 286-294
    • Werner, J.1    Laposata, M.2    Fernandez-del Castillo, C.3
  • 57
    • 34247197621 scopus 로고    scopus 로고
    • Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy
    • Witt H., Apte M.V., Keim V., Wilson J.S. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 2007, 132:1557-1573.
    • (2007) Gastroenterology , vol.132 , pp. 1557-1573
    • Witt, H.1    Apte, M.V.2    Keim, V.3    Wilson, J.S.4
  • 58
    • 37749028739 scopus 로고    scopus 로고
    • Ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells: role of fatty acid ethyl esters
    • Wu H., Bhopale K.K., Ansari G.A.S., Kaphalia B.S. Ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells: role of fatty acid ethyl esters. Alcohol Alcohol. 2008, 43:1-8.
    • (2008) Alcohol Alcohol. , vol.43 , pp. 1-8
    • Wu, H.1    Bhopale, K.K.2    Ansari, G.A.S.3    Kaphalia, B.S.4
  • 59
    • 33749070988 scopus 로고    scopus 로고
    • Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: role of nonoxidative metabolism
    • Wu H., Cai P., Clemens D.L., Jerrells T.R., Ansari G.A., Kaphalia B.S. Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: role of nonoxidative metabolism. Toxicol. Appl. Pharmacol. 2006, 216:238-247.
    • (2006) Toxicol. Appl. Pharmacol. , vol.216 , pp. 238-247
    • Wu, H.1    Cai, P.2    Clemens, D.L.3    Jerrells, T.R.4    Ansari, G.A.5    Kaphalia, B.S.6
  • 60
    • 0018893468 scopus 로고
    • Underestimation of alcohol dehydrogenase as a result of various technical pitfalls of the enzyme assay
    • Zahlten R.N., Jacobson C.J., Neijtek M.E. Underestimation of alcohol dehydrogenase as a result of various technical pitfalls of the enzyme assay. Biochem. Pharmacol. 1980, 29:1973-1976.
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 1973-1976
    • Zahlten, R.N.1    Jacobson, C.J.2    Neijtek, M.E.3
  • 61
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • Zhang K., Shen X., Wu J., et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 2006, 124:587-599.
    • (2006) Cell , vol.124 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.