Immunohistological profile of the ras homologous B protein (RhoB) in human testes showing normal spermatogenesis, spermatogenic arrest and sertoli cell only syndrome

Pathology and Oncology Research

Volumn 16, Issue 3, 2010, Pages 427-433

  Adly, Mohamed A ^a,b   Hussein, Mahmoud Rezk Abdelwahed ^c  

^a Sohag University   (Egypt)

^b KING KHALID UNIVERSITY   (Saudi Arabia)

^c NONE

Author keywords

Fertility; Human testis; Infertility; Ras; RhoB

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; RAS HOMOLOGOUS B PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; CYTOPLASM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOLOGY; LEYDIG CELL; MALE; MALE INFERTILITY; MYOFIBROBLAST; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; SERTOLI CELL ONLY SYNDROME; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; TESTIS BIOPSY; TESTIS DISEASE;

FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; INFERTILITY, MALE; MALE; RHOB GTP-BINDING PROTEIN; SERTOLI CELL-ONLY SYNDROME; SPERMATOGENESIS; TESTIS;

EID: 77956878059     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-009-9232-3     Document Type: Article

References (26)

1. E Hu 2006 Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases Recent Patents Cardiovasc Drug Discov 1 249 263 1:CAS:528:DC%2BD28Xht1GntrbE 10.2174/157489006778777034
2. A Berken A Wittinghofer 2008 Structure and function of Rho-type molecular switches in plants Plant Physiol Biochem 46 380 393 1:CAS:528: DC%2BD1cXjs1KmsLk%3D 10.1016/j.plaphy.2007.12.008 18272378
3. JM Nowak A Grzanka A Zuryn A Stepien 2008 The Rho protein family and its role in the cellular cytoskeleton Postepy Hig Med Dosw (Online) 62 110 117
4. MH Modarressi M Cheng HA Tarnasky N Lamarche-Vane DG de Rooij Y Ruan FA van der Hoorn 2004 A novel testicular RhoGAP-domain protein induces apoptosis Biol Reprod 71 1980 1990 1:CAS:528:DC%2BD2cXhtVWgsr3F 10.1095/biolreprod.104. 032805 15306557
5. H Genth SC Dreger J Huelsenbeck I Just 2008 Clostridium difficile toxins: more than mere inhibitors of Rho proteins Int J Biochem Cell Biol 40 592 597 1:CAS:528:DC%2BD1cXivVOmtb8%3D 10.1016/j.biocel.2007.12.014 18289919
6. T Nakakuki M Ito H Iwasaki Y Kureishi R Okamoto N Moriki M Kongo S Kato N Yamada N Isaka T Nakano 2005 Rho/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cells Arterioscler Thromb Vasc Biol 25 2088 2093 1:CAS:528:DC%2BD2MXhtVCltrnJ 10.1161/01.ATV.0000183607.50230.9f 16123329
7. L Sequeira CW Dubyk TA Riesenberger CR Cooper KL van Golen 2008 Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis Clin Exp Metastasis 25 569 579 1:CAS:528:DC%2BD1cXhtVWmsLbL 10.1007/s10585-008-9173-3 18461284
8. Zhao L, Wang H, Li J, Liu Y, Ding Y (2008) Overexpression of Rho GDP-dissociation inhibitor Alpha is associated with tumor progression and poor prognosis of colorectal cancer. J Proteome Res 7(9):3994-4003
9. RW Scott MF Olson 2007 LIM kinases: function, regulation and association with human disease J Mol Med 85 555 568 1:CAS:528:DC%2BD2sXmtVGjurs%3D 10.1007/s00109-007-0165-6 17294230
10. S Ramos F Khademi BP Somesh F Rivero 2002 Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse Gene 298 147 157 1:CAS:528:DC%2BD38XotlKnu7k%3D 10.1016/S0378-1119(02)00980-0 12426103
11. GY Liu SZ Gao CR Ge X Zhang 2008 Cloning, nucleotide sequence and tissue expression profile of three novel porcine genes-RHOB, RHOG and PRAF1 Mol Biol (Mosk) 42 59 62 1:STN:280:DC%2BD1c3jt1yquw%3D%3D
12. TJ Kao CF Millette 2007 L-type voltage-operated Ca(+2) channels modulate transient Ca(+2) influx triggered by activation of Sertoli cell surface L-selectin J Cell Biochem 101 1023 1037 1:CAS:528:DC%2BD2sXnvVWjs78%3D 10.1002/jcb.21135 17477368
13. WY Lui WM Lee CY Cheng 2003 Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway Biol Reprod 68 2189 2206 1:CAS:528:DC%2BD3sXks1Ggsbg%3D 10.1095/biolreprod.102. 011379 12606349
14. WY Lui WM Lee CY Cheng 2003 Rho GTPases and spermatogenesis Biochim Biophys Acta 1593 121 129 1:CAS:528:DC%2BD3sXhtVGitbY%3D 10.1016/S0167-4889(02) 00348-8 12581856
15. WY Lui DD Mruk CY Cheng 2005 Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis J Cell Physiol 202 49 66 1:CAS:528:DC%2BD2cXhtVOlsb7J 10.1002/jcp.20098 15389538
16. H Shim H Lee D Jeoung 2006 Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK) Biotechnol Lett 28 2057 2063 1:CAS:528:DC%2BD28Xht1GmsrvI 10.1007/s10529-006-9190-8 17028776
17. T Kamai K Arai T Tsujii M Honda K Yoshida 2001 Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour BJU Int 87 227 231 1:CAS:528:DC%2BD3MXhsVWrtLw%3D 10.1046/j.1464-410x.2001.02030.x 11167647
18. MR Hussein ES Abou-Deif MA Bedaiwy TM Said MG Mustafa E Nada A Ezat A Agarwal 2005 Phenotypic characterization of the immune and mast cell infiltrates in the human testis shows normal and abnormal spermatogenesis Fertil Steril 83 1447 1453 10.1016/j.fertnstert.2004.11.062 15866583
19. MR Hussein EE Abu-Dief AT Abou El-Ghait MA Adly MH Abdelraheem 2006 Melatonin and roentgen irradiation of the testis Fertil Steril 86 750 752 1:CAS:528:DC%2BD28XhtFCqsLzL 10.1016/j.fertnstert.2006.02.094 16854416
20. MR Hussein EE Abu-Dief AT Abou El-Ghait MA Adly MH Abdelraheem 2006 Morphological evaluation of the radioprotective effects of melatonin against X-ray-induced early and acute testis damage in Albino rats: an animal model Int J Exp Pathol 87 237 250 10.1111/j.1365-2613.2006.00480.x 16709232
21. K Hirano F Matsuura K Tsukamoto Z Zhang A Matsuyama K Takaishi R Komuro T Suehiro S Yamashita Y Takai Y Matsuzawa 2000 Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease-the small G protein may play a role in cholesterol efflux FEBS Lett 484 275 279 1:CAS:528:DC%2BD3cXotVCku70%3D 10.1016/S0014-5793(00)02171-2 11078892
22. EA Freeman P Jani CE Millette 2002 Expression and potential function of Rho family small G proteins in cells of the mammalian seminiferous epithelium Cell Commun Adhes 9 189 204 1:CAS:528:DC%2BD3sXivVyms7s%3D 10.1080/ 15419060216016 12699088
23. K Nakamura A Fujita T Murata G Watanabe C Mori J Fujita N Watanabe T Ishizaki O Yoshida S Narumiya 1999 Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail FEBS Lett 445 9 13 1:CAS:528: DyaK1MXht1Ohur0%3D 10.1016/S0014-5793(99)00087-3 10069364
24. H Takahashi U Koshimizu J Miyazaki T Nakamura 2002 Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene Dev Biol 241 259 272 1:CAS:528:DC%2BD38XhsFGhtA%3D%3D 10.1006/dbio.2001.0512 11784110
25. FD Cunto S Imarisio P Camera C Boitani F Altruda L Silengo 2002 Essential role of citron kinase in cytokinesis of spermatogenic precursors J Cell Sci 115 4819 4826 10.1242/jcs.00163 12432070
26. A Togawa J Miyoshi H Ishizaki M Tanaka A Takakura H Nishioka H Yoshida T Doi A Mizoguchi N Matsuura Y Niho Y Nishimune S Nishikawa Y Takai 1999 Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha Oncogene 18 5373 5380 1:CAS:528:DyaK1MXms1OhsL4%3D 10.1038/sj.onc. 1202921 10498891