Clonal origin of multifocal hepatocellular carcinoma

Cancer

Volumn 116, Issue 17, 2010, Pages 4078-4085

  Hodges, Kurt B ^a,b   Cummings, Oscar W ^a   Saxena, Romil ^a   Wang, Mingsheng ^a   Zhang, Shaobo ^a   Lopez Beltran, Antonio ^c   Montironi, Rodolfo ^d   Nour, Hammam ^a   Cheng, Liang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF CÓRDOBA   (Spain)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Clonality; Liver; Loss of heterozygosity; Multifocal; TP53 mutation

Indexed keywords

FORMALDEHYDE; GENOMIC DNA; PARAFFIN; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; DNA DETERMINATION; DNA EXTRACTION; EXON; FEMALE; GENE MUTATION; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; LIVER CELL CARCINOMA; MALE; MICROSATELLITE MARKER; MOLECULAR CLONING; MULTIPLE CANCER; OUTCOME ASSESSMENT; POINT MUTATION; PRIORITY JOURNAL; TUMOR VOLUME; TWIN DISCORDANCE; X CHROMOSOME INACTIVATION; GENETICS; LIVER TUMOR; MIDDLE AGED; MUTATION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; GENES, P53; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION; X CHROMOSOME INACTIVATION;

EID: 77956858525     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25258     Document Type: Article

References (34)

1. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol. 2009;27:1485-1491.
2. El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology. 2004;127:S27-S34.
3. van der Sijp JR, van Meerbeeck JP, Maat AP, et al. Determination of the molecular relationship between multiple tumors within 1 patient is of clinical importance. J Clin Oncol. 2002;20:1105-1114.
4. Hamilton SR, Aaltonen LA. World Health Organization: Pathology and Genetics. Tumours of the Digestive Systems. Lyon, France: IARC Press; 2000.
5. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954;7:462-503.
6. Greene FL, Page DL, Fleming ID, et al, eds. American Joint Committee on Cancer Staging Manual. 6th ed. New York, NY: Springer-Verlag; 2002.
7. Cheng L, Jones TD, McCarthy RP, et al. Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma. Am J Pathol. 2005;166:1533-1539.
8. Cheng L, Gu J, Ulbright TM, et al. Precise microdissection of human bladder carcinomas reveals divergent tumor subclones in the same tumor. Cancer. 2002;94:104-110.
9. Cheng L, MacLennan GT, Zhang S, Wang M, Pan CX, Koch MO. Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder. Cancer. 2004;101:183-188.
10. Cheng L, Zhang S, Wang M, et al. Molecular genetic evidence supporting the neoplastic nature of stromal cells in 'fibrosis' after chemotherapy for testicular germ cell tumors. J Pathol. 2007;213:65-71.
11. Anzola M, Cuevas N, Lopez-Martinez M, et al. P14ARF gene alterations in human hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2004;16:19-26.
12. Wang G, Huang CH, Zhao Y, et al. Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23. Cell Res. 2000;10:311-323.
13. Cheng L, Zhang D. Molecular Genetic Pathology. New York, NY: Humana Press/Springer; 2008.
14. Hodges KB, Abdul-Karim FW, Wang M, et al. Evidence for transformation of fibroadenoma of the breast to malignant phyllodes tumor. Appl Immunohistochem Mol Morphol. 2009;17:345-350.
15. Cheng L, Gu J, Eble JN, et al. Molecular genetic evidence for different clonal origin of components of human renal angiomyolipomas. Am J Surg Pathol. 2001;25:1231-1236.
16. Gu J, Roth LM, Younger C, et al. Molecular evidence for the independent origin of extra-ovarian papillary serous tumors of low malignant potential. J Natl Cancer Inst. 2001;93:1147-1152.
17. Armstrong AB, Wang M, Eble JN, et al. TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder. Mod Pathol. 2009;22:113-118.
18. Wang X, Wang M, MacLennan GT, et al. Evidence for common clonal origin of multifocal lung cancers. J Natl Cancer Inst. 2009;101:560-570.
19. Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature. 1991;351:453-456.
20. Yano M, Hamatani K, Eguchi H, et al. Prognosis in patients with hepatocellular carcinoma correlates to mutations of p53 and/or hMSH2 genes. Eur J Cancer. 2007;43:1092-1100.
21. Li Q, Wang J, Juzi JT, et al. Clonality analysis for multicentric origin and intrahepatic metastasis in recurrent and primary hepatocellular carcinoma. J Gastrointest Surg. 2008;12:1540-1547.
22. Finkelstein SD, Marsh W, Demetris AJ, et al. Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma. Hepatology. 2003;37:871-879.
23. Nomoto S, Kinoshita T, Kato K, et al. Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. Br J Cancer. 2007;97:1260-1265.
24. Nakata T, Seki N, Miwa S, et al. Identification of genes associated with multiple nodules in hepatocellular carcinoma using cDNA microarray: multicentric occurrence or intrahepatic metastasis? Hepatogastroenterology. 2008;55:865-872.
25. Morimoto O, Nagano H, Sakon M, et al. Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas. J Hepatol. 2003;39:215-221.
26. Yamamoto T, Kajino K, Kudo M, Sasaki Y, Arakawa Y, Hino O. Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA. Hepatology. 1999;29:1446-1452.
27. Park NH, Chung YH, Youn KH, et al. Close correlation of p53 mutation to microvascular invasion in hepatocellular carcinoma. J Clin Gastroenterol. 2001;33:397-401.
28. Chen PJ, Chen DS, Lai MY, et al. Clonal origin of recurrent hepatocellular carcinomas. Gastroenterology. 1989;96:527-529.
29. Cheng L, MacLennan GT, Zhang S, et al. Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma. Clin Cancer Res. 2008;14:8087-8093.
30. Katona TM, Jones TD, Wang M, Abdul-Karim FW, Cummings OW, Cheng L. Molecular evidence for independent origin of multifocal neuroendocrine tumors of the enteropancreatic axis. Cancer Res. 2006;66:4936-4942.
31. Jones TD, Wang M, Eble JN, et al. Molecular evidence supporting field effect in urothelial carcinogenesis. Clin Cancer Res. 2005;11:6512-6519.
32. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953;6:963-968.
33. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. American Joint Committee on Cancer Staging Manual. 7th ed. New York, NY: Springer-Verlag; 2010.
34. Dvorchik I, Schwartz M, Fiel MI, Finkelstein SD, Marsh JW. Fractional allelic imbalance could allow for the development of an equitable transplant selection policy for patients with hepatocellular carcinoma. Liver Transpl. 2008;14:443-450.