siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells

Journal of Toxicological Sciences

Volumn 35, Issue 4, 2010, Pages 601-604

  Hwang, Gi Wook ^a   Tobita, Mayumi ^a   Takahashi, Tsutomu ^a   Kuge, Shusuke ^a,b   Kita, Kayoko ^a,c   Naganuma, Akira ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

AICAR; AMP activated protein kinase; Methylmercury; PRKAA1 (AMPK 1)

Indexed keywords

5 AMINOIMIDAZOLE 4 CARBOXAMIDE 1 BETA DEXTRA RIBOFURANOSIDE; ADENOSINE PHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; METHYLMERCURY; UNCLASSIFIED DRUG; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; DRUG DERIVATIVE; METHYLMERCURY DERIVATIVE; PRKAA1 PROTEIN, HUMAN; RIBONUCLEOTIDE; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HEK293; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; KIDNEY CELL; PRKAA1 GENE; TOXICITY; DRUG ANTAGONISM; GENETICS; METABOLISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; HEK293 CELLS; HUMANS; METHYLMERCURY COMPOUNDS; RIBONUCLEOTIDES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 77956828882     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.601     Document Type: Article

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