Protective effect of urantide against myocardial ischemia-reperfusion injury

Chinese Pharmacological Bulletin

Volumn 26, Issue 5, 2010, Pages 661-666

  Yao, Hua ^a   Zhang, Jun Yan ^a   Chen, Zhi Wu ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Inducible nitric oxide synthase; Ischemic preconditioning; Malondialdehyde; Myocardial ischemia reperfusion injury; Nitric oxide; Urantide

Indexed keywords

EVANS BLUE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; URANTIDE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DOWN REGULATION; ELECTROCARDIOGRAM; ENZYME ACTIVITY; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID PEROXIDATION; MODEL; NONHUMAN; PERFUSION; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; ST SEGMENT; ST SEGMENT ELEVATION; WESTERN BLOTTING;

EID: 77956808317     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Bern H A, Lederis K. A reference preparation for the study of aclive substances in the caudal neurosecretory system of teleosts [J]. J Endocrinol, 1969,45(1):Suppl:xi-xii.
2. Ames R S, Sarau H M, Chambers J K, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 [J]. Nature, 1999,401(6750):282-6.
3. Zhu X M, Du G H. Progress in the study of biological activities of urotensin II [J]. Chin Pharmacol Bull, 2006,22(6):651-4.
4. Camarda V, Song W, Marzola E, et al. Urantide mimics urotensin - II induced calcium release in cells expressing recombinant UT receptors [J]. Eur J Pharmacol, 2004,498,(1-3):83-6 (Pubitemid 39208064)
5. Patacehini R, Santieioli P, Giuliani S, et al. Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta [J]. Br J Pharmacol, 2003,140(7):1155-8. (Pubitemid 38117417)
6. Yao H, Chen Z W. Protective role of urantide on myocardiaL ischemia injury[J]. Acta Pharm Sin, 2008;43(2):2-8
7. Wang T L, Chang H, Hung C R, et al. Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction [J].Cardiovasc Res, 1998,40:557-63 (Pubitemid 28557297)
8. Green D E, Lester R L, Zifgier D M. Studies on the mechanism of oxidation phosphorylation [J]. Biochem Biophys Acta, 1957,23:516-24.
9. + Channels in rat hearts [J]. Am J Physiol Heart Circ Physiol, 2006,290(5):H1808-17.
10. Ping P, Takano H, Zhang J, et al. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning [J]. Circ Res, 1999,84:587-604 (Pubitemid 29138595)
11. Goligorsky M S, Brodsky S V, Noiri E. Nitric oxide in acute renal failure: NOS vs. NOS[J]. Kidney Int, 2002,61:855-61
12. Chatterjee P K, Patel N S, Sivarajah A, et al. GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury [J]. Kidney Int, 2003,63(3):853-65. (Pubitemid 36315563)
13. Qi W N, Chaiyakit P, Cai Y, et al. NF-kappa-B p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle [J]. Microsurgery, 2004,24:316-23. (Pubitemid 38988582)
14. Harbrecht BG, Wu B, Watkins S C, et al. Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury [J]. Shock, 1995,4:332-7.
15. Bousette N, Hu F, ohlstein E H, et al. Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation [J]. J Mol Cell Cardiol, 2006,41(2):285-95. (Pubitemid 44080219)
16. Zhou P, Wu S Y, Yu C F, et al. Effects of urotensin on isolated rat hearts under normal perfusion and ischemia -reperfusion [J]. Acta Physionl Sin, 2003,55(4):442-8. (Pubitemid 37101603)