메뉴 건너뛰기




Volumn 40, Issue 9, 2010, Pages 611-618

The current status of targeted therapy for non-small cell lung cancer

Author keywords

epidermal growth factor receptor; erlotinib; gefitinib; non small cell lung cancer; targeted therapy; vascular endothelial growth factor

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; AFLIBERCEPT; ANTIBIOTIC AGENT; AXITINIB; BEVACIZUMAB; CARBOPLATIN; CEDIRANIB; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FIGITUMUMAB; GEFITINIB; MINOCYCLINE; MOTESANIB; N [4 (3 CHLORO 4 FLUOROANILINO) 7 (TETRAHYDRO 3 FURYLOXY) 6 QUINAZOLINYL] 4 DIMETHYLAMINO 2 BUTENAMIDE; NAVELBINE; PACLITAXEL; PANITUMUMAB; PAZOPANIB; PEMETREXED; PF 299804; SORAFENIB; STEROID; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

EID: 77956801719     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2009.02141.x     Document Type: Review
Times cited : (20)

References (46)
  • 1
    • 70349302892 scopus 로고    scopus 로고
    • AIHW (Australian Institute of Health and Welfare) and AACR (Australasian Association of Cancer Registries). Cancer series no. 46. Cat. no. CAN 42
    • AIHW (Australian Institute of Health and Welfare) and AACR (Australasian Association of Cancer Registries). Cancer in Australia: An Overview, 2008. Cancer series no. 46. Cat. no. CAN 42.
    • Cancer in Australia: An Overview, 2008.
  • 3
    • 77956853756 scopus 로고    scopus 로고
    • The quantification of drug-caused mortality and morbidity in Australia
    • Ridolfo B, Stevenson C. The quantification of drug-caused mortality and morbidity in Australia, 1998. AIHW Cat. No. PHE 29.
    • (1998) AIHW Cat. No. PHE 29
    • Ridolfo, B.1    Stevenson, C.2
  • 4
    • 0028843552 scopus 로고
    • Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
    • Non-small Cell Lung Cancer Collaborative Group
    • Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 1995 311 : 899 909.
    • (1995) BMJ , vol.311 , pp. 899-909
  • 6
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N, Shepherd FA, Fossella FV, Pereira JR, De Marinis F, von Pawel J et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004 22 : 1589 97.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-97
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3    Pereira, J.R.4    De Marinis, F.5    Von Pawel, J.6
  • 7
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
    • Shepherd FA, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000 18 : 2095 103.
    • (2000) J Clin Oncol , vol.18 , pp. 2095-103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3    Mattson, K.4    Gralla, R.5    O'Rourke, M.6
  • 8
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008 358 : 1160 74.
    • (2008) N Engl J Med , vol.358 , pp. 1160-74
    • Ciardiello, F.1    Tortora, G.2
  • 9
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial)
    • Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial). J Clin Oncol 2003 21 : 2237 46.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-46
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3    Tamura, T.4    Nakagawa, K.5    Douillard, J.Y.6
  • 10
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, Lynch TJ Jr., Prager D, Belani CP et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003 290 : 2149 58.
    • (2003) JAMA , vol.290 , pp. 2149-58
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3    Lynch Jr., T.J.4    Prager, D.5    Belani, C.P.6
  • 11
    • 4344646459 scopus 로고    scopus 로고
    • Determinants of tumor response and survival with erlotinib in patients with non - Small-cell lung cancer
    • Perez-Soler R, Chachoua A, Hammond LA, Rowinsky EK, Huberman M, Karp D et al. Determinants of tumor response and survival with erlotinib in patients with non - small-cell lung cancer. J Clin Oncol 2004 22 : 3238 47.
    • (2004) J Clin Oncol , vol.22 , pp. 3238-47
    • Perez-Soler, R.1    Chachoua, A.2    Hammond, L.A.3    Rowinsky, E.K.4    Huberman, M.5    Karp, D.6
  • 13
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005 366 : 1527 37.
    • (2005) Lancet , vol.366 , pp. 1527-37
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Rodrigues Pereira, J.4    Ciuleanu, T.5    Von Pawel, J.6
  • 14
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • Kim ES, Hirsh V, Mok T, Socinski MA, Gervais R, Wu YL et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 2008 372 : 1809 18.
    • (2008) Lancet , vol.372 , pp. 1809-18
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3    Socinski, M.A.4    Gervais, R.5    Wu, Y.L.6
  • 15
    • 34248140107 scopus 로고    scopus 로고
    • Phase III study of Erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The tarceva lung cancer investigation trial
    • Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F et al. Phase III study of Erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the tarceva lung cancer investigation trial. J Clin Oncol 2007 25 : 1545 52.
    • (2007) J Clin Oncol , vol.25 , pp. 1545-52
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3    Kaukel, E.4    Roubec, J.5    De Rosa, F.6
  • 16
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in Advanced non-small-cell lung cancer: A phase III trial - INTACT 1
    • Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V et al. Gefitinib in combination with gemcitabine and cisplatin in Advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004 22 : 777 84.
    • (2004) J Clin Oncol , vol.22 , pp. 777-84
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3    Scagliotti, G.4    Rosell, R.5    Miller, V.6
  • 17
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2. J Clin Oncol 2004 22 : 785 94.
    • (2004) J Clin Oncol , vol.22 , pp. 785-94
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3    Natale, R.B.4    Miller, V.5    Manegold, C.6
  • 18
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005 23 : 5892 99.
    • (2005) J Clin Oncol , vol.23 , pp. 5892-99
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3    Fehrenbacher, L.4    Johnson, B.E.5    Sandler, A.6
  • 19
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009 373 : 1525 31.
    • (2009) Lancet , vol.373 , pp. 1525-31
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3    Von Pawel, J.4    Krzakowski, M.5    Ramlau, R.6
  • 20
    • 39849111354 scopus 로고    scopus 로고
    • A randomized multicenter phase III study of cetuximab (Erbitux[R]) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC): BMS 099
    • Suppl
    • Lynch T, Patel T, Dreisbach L, McCleod M, Heim WJ, Robert H et al. A randomized multicenter phase III study of cetuximab (Erbitux[R]) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC): BMS 099. J Thorac Oncol 2007 2 (Suppl 8 S340 1.
    • (2007) J Thorac Oncol , vol.2 , Issue.8
    • Lynch, T.1    Patel, T.2    Dreisbach, L.3    McCleod, M.4    Heim, W.J.5    Robert, H.6
  • 22
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F, Hirsch FR, Rossi E, Bartolini S, Ceresoli GL, Bemis L et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005 97 : 643 55.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-55
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3    Bartolini, S.4    Ceresoli, G.L.5    Bemis, L.6
  • 23
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004 350 : 2129 39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-39
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 24
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004 304 : 1497 500.
    • (2004) Science , vol.304 , pp. 1497-500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 25
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I et al. EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004 101 : 13306 11.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-11
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6
  • 26
    • 69349088824 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials
    • Jackman DM, Miller VA, Cioffredi L-A, Yeap BY, Janne PA, Riely GJ et al. Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials. Clin Cancer Res 2009 15 : 5267 73.
    • (2009) Clin Cancer Res , vol.15 , pp. 5267-73
    • Jackman, D.M.1    Miller, V.A.2    Cioffredi, L.-A.3    Yeap, B.Y.4    Janne, P.A.5    Riely, G.J.6
  • 28
    • 34347393745 scopus 로고    scopus 로고
    • Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: A multicohort cross-institutional study
    • Taguchi F, Solomon B, Gregorc V, Roder H, Gray R, Kasahara K et al. Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study. J Natl Cancer Inst 2007 99 : 838 46.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 838-46
    • Taguchi, F.1    Solomon, B.2    Gregorc, V.3    Roder, H.4    Gray, R.5    Kasahara, K.6
  • 29
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005 2 : e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 30
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007 316 : 1039 43.
    • (2007) Science , vol.316 , pp. 1039-43
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 31
    • 35548969264 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: An evolving paradigm in clinical management
    • Lynch TJ Jr., Kim ES, Eaby B, Garey J, West DP, Lacouture ME. Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management. Oncologist 2007 12 : 610 21.
    • (2007) Oncologist , vol.12 , pp. 610-21
    • Lynch Jr., T.J.1    Kim, E.S.2    Eaby, B.3    Garey, J.4    West, D.P.5    Lacouture, M.E.6
  • 32
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000 100 : 57 70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 33
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971 285 : 1182 6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-6
    • Folkman, J.1
  • 34
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004 22 : 2184 91.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-91
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.J.5    Jablons, D.M.6
  • 35
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006 355 : 2542 50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-50
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 36
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of Eastern Cooperative Oncology Group Trial 4599
    • Ramalingam SS, Dahlberg SE, Langer CJ, Gray R, Belani CP, Brahmer JR et al. Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599. J Clin Oncol 2008 26 : 60 5.
    • (2008) J Clin Oncol , vol.26 , pp. 60-5
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3    Gray, R.4    Belani, C.P.5    Brahmer, J.R.6
  • 37
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009 27 : 1227 34.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-34
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6
  • 38
    • 70349474058 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL)
    • Suppl. abstract 8010). (
    • De Boer R, Arrieta Ó, Gottfried M, Blackhall FH, Raats J, Yang CH et al. Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): a randomized, double-blind phase III trial (ZEAL). J Clin Oncol 2009 27 (Suppl. S15 (abstract 8010).
    • (2009) J Clin Oncol , vol.27
    • De Boer, R.1    Arrieta, Ó.2    Gottfried, M.3    Blackhall, F.H.4    Raats, J.5    Yang, C.H.6
  • 39
    • 69349097838 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC)
    • Suppl. abstract CRA8003). (
    • Herbst RS, Sun Y, Korfee S, Germonpré P, Saijo N, Zhou C et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): a randomized, double-blind phase III trial (ZODIAC). J Clin Oncol 2009 27 (Suppl. S18 (abstract CRA8003).
    • (2009) J Clin Oncol , vol.27
    • Herbst, R.S.1    Sun, Y.2    Korfee, S.3    Germonpré, P.4    Saijo, N.5    Zhou, C.6
  • 40
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • JCO.2009.22.0541
    • Blumenschein GR Jr., Gatzemeier U, Fossella F, Stewart DJ, Cupit L, Cihon F et al. Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 2009 27 : 4274 80. JCO.2009.22.0541.
    • (2009) J Clin Oncol , vol.27 , pp. 4274-80
    • Blumenschein Jr., G.R.1    Gatzemeier, U.2    Fossella, F.3    Stewart, D.J.4    Cupit, L.5    Cihon, F.6
  • 41
  • 42
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009 27 : 2516 22.
    • (2009) J Clin Oncol , vol.27 , pp. 2516-22
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3    Haluska, P.4    Garland, L.5    Cardenal, F.6
  • 43
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007 448 : 561 6.
    • (2007) Nature , vol.448 , pp. 561-6
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3    Takada, S.4    Yamashita, Y.5    Ishikawa, S.6
  • 44
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • JCO.2009.22.6993
    • Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009 27 : 4247 53. JCO.2009.22.6993.
    • (2009) J Clin Oncol , vol.27 , pp. 4247-53
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3    Digumarthy, S.R.4    Costa, D.B.5    Heist, R.S.6
  • 45
    • 70350140489 scopus 로고    scopus 로고
    • Clinical activity observed in a phase i dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
    • Suppl. abstract 3509). (
    • Kwak EL, Camidge DR, Clark J, Shapiro GI, Maki RG, Ratain MJ et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol 2009 27 (Suppl. S15 (abstract 3509).
    • (2009) J Clin Oncol , vol.27
    • Kwak, E.L.1    Camidge, D.R.2    Clark, J.3    Shapiro, G.I.4    Maki, R.G.5    Ratain, M.J.6
  • 46
    • 67651246671 scopus 로고    scopus 로고
    • Phase i study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
    • Suppl. abstract 9000). (
    • Flaherty K, Puzanov I, Sosman J, Kim K, Ribas A, McArthur G et al. Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J Clin Oncol 2009 27 (Suppl. S15 (abstract 9000).
    • (2009) J Clin Oncol , vol.27
    • Flaherty, K.1    Puzanov, I.2    Sosman, J.3    Kim, K.4    Ribas, A.5    McArthur, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.