Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition

Acta Biomaterialia

Volumn 6, Issue 9, 2010, Pages 3611-3620

  Barroca, N ^a   Daniel Da Silva, A L ^a   Vilarinho, P M ^a   Fernandes, M H V ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

Bioactive glass; Crystallinity; Poly(L lactic) acid; Porosity; Thermally induced phase separation

Indexed keywords

BIOACTIVE GLASS; MAGNESIA; MOLECULAR WEIGHT; PHASE SEPARATION; PORE SIZE; SCAFFOLDS (BIOLOGY); SILICA; SURFACE ACTIVE AGENTS; TISSUE;

BIOGLASSES; CRISTALLINITY; HIGH MOLECULAR WEIGHT; MGO-SIO; POLY-L-LACTIC ACIDS; POLYMERIC SCAFFOLD; POROUS STRUCTURES; THERMALLY INDUCED PHASE SEPARATION; THERMALLY-INDUCED PHASE SEPARATION; TISSUE ENGINEERING APPLICATIONS;

SOLUBILITY;

CALCIUM SILICATE; GLASS; MAGNESIUM OXIDE; PHOSPHORUS PENTOXIDE; POLYLACTIC ACID; SILICON DIOXIDE; BIOGLASS; BIOMATERIAL; CERAMICS; ION; LACTIC ACID; POLYMER;

ARTICLE; CRYSTALLIZATION; IN VITRO STUDY; MOLECULAR WEIGHT; MORPHOLOGY; POROSITY; PRIORITY JOURNAL; SOLUBILITY; CERAMICS; CHEMISTRY; COMPRESSIVE STRENGTH; DIFFERENTIAL SCANNING CALORIMETRY; INFRARED SPECTROSCOPY; PARTICLE SIZE; RADIATION SCATTERING; SCANNING ELECTRON MICROSCOPY; TEMPERATURE; TIME; TISSUE SCAFFOLD; YOUNG MODULUS;

BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CERAMICS; COMPRESSIVE STRENGTH; CRYSTALLIZATION; ELASTIC MODULUS; IONS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; PARTICLE SIZE; POLYMERS; POROSITY; SCATTERING, RADIATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; TIME FACTORS; TISSUE SCAFFOLDS;

EID: 77956770177     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.03.032     Document Type: Article

References (41)

1. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006;27:3413-31.
2. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-43.
3. Zhang K, Wang Y, Hillmyer MA, Francis LF. Processing and properties of porous poly (L-lactide)/bioactive glass composites. Biomaterials 2004;25:2489-500.
4. ® composite scaffolds for bone tissue engineering: I. Preparation and in vitro characterization. Biomaterials 2004;25:4185-94.
5. ® particles for tissue engineering applications. J Mater Sci Mater Med 2003;14:443-50.
6. Lu HH, Tang A, Oh SC, Spalazzi JP, Dionisio K. Compositional effects on the formation of a calcium phosphate layer and the response of osteoblast-like cells on polymer-bioactive glass composites. Biomaterials 2005;26:6323-34.
7. Lopes P, Corbellini M, Ferreira BL, Almeida N, Fredel M, Fernandes MH, et al. New PMMA-co-EHA glass-filled composites for biomedical applications: mechanical properties and bioactivity. Acta Biomater 2009;5:356-62.
8. 2-MgO glass. Mater Sci Eng C 2008;28:572-7.
9. Bosetti M, Cannas M. The effect of bioactive glasses on bone marrow stromal cells differentiation. Biomaterials 2005;26:3873-9.
10. Jell G, Stevens MM. Gene activation by bioactive glasses. J Mater Sci Mater Med 2006;17:997-1002.
11. Charles-Harris M, del Valle S, Hentges E, Bleuet P, Lacroix D, Planell JA. Mechanical and structural characterisation of completely degradable polylactic acid/calcium phosphate glass scaffolds. Biomaterials 2007;28:4429-38.
12. Nam YS, Park TG. Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. Biomaterials 1999;20:1783-90.
13. Kim HD, Bae EH, Kwon IC, Pal RR, Nam JD, Lee DS. Effect of PEG-PLLA diblock copolymer on macroporous PLLA scaffolds by thermally induced phase separation. Biomaterials 2004;25:2319-29.
14. Cao Y, Davidson MR, O'Connor AJ, Stevens GW, Cooper-White JJ. Architecture control of three-dimensional polymeric scaffolds for soft tissue engineering: I. Establishment and validation of numerical models. J Biomed Mater Res A 2004;71 A: 81-9.
15. Hua FJ, Kim GE, Lee JD, Son YK, Lee DS. Macroporous poly (L-lactide) scaffold 1. Preparation of a macroporous scaffold by liquid-liquid phase separation of a PLLA-dioxane-water system. J Biomed Mater Res 2003;63:161-7.
16. Carfi Pavia F, La Carrubba V, Piccarolo S, Brucato V. Polymeric scaffolds prepared via thermally induced phase separation: tuning of structure and morphology. J Biomed Mater Res A 2008;86 A: 459-66.
17. Hua FJ, Nam JD, Lee DS. Preparation of a macroporous poly (L-lactide) scaffold by liquid-liquid phase separation of a PLLA/1, 4-dioxane/water ternary system in the presence of NaCl. Macromol Rapid Commun 2001;22:1053-7.
18. Gong Y, Ma Z, Gao C, Wang W, Shen J. Specially elaborated thermally induced phase separation to fabricate poly (L-lactic acid) scaffolds with ultra large pores and good interconnectivity. J Appl Polym Sci 2006;101:3336-42.
19. He L, Zhang Y, Zeng X, Quan D, Liao S, Zeng Y, et al. Fabrication and characterization of poly (L-lactic acid) 3D nanofibrous scaffolds with controlled architecture by liquid-liquid phase separation from a ternary polymer-solvent system. Polymer 2009;50:4128-38.
20. Zhou WY, Lee SH, Wang M, Cheung WL, Ip WY. Selective laser sintering of porous tissue from poly (L-lactide)/carbonated hydroxyapatite nanocomposite microspheres. J Mater Sci Mater Med 2008;19:2535-40.
21. van de Witte P, Dijkstra PJ, van den Berg JWA, Feijen J. Phase separation processes in polymer solutions in relation to membrane formation. J Membr Sci 1996;117:1-31.
22. Kokubo T, Takadama H. How useful is SBF predicting in vivo bone bioactivity. Biomaterials 2006;27:2907-15.
23. Mano JF, Ribelles JLG, Alves NM, Sanchez MS. Glass transition dynamics and structural relaxation of PLLA studied by DSC: influence of crystallinity. Polymer 2005;46:8258-65.
24. Mano JF, Wang Y, Viana JC, Denchev Z, Oliveira MJ. Cold crystallization of PLLA studied by simultaneous SAXS and WAXS. Macromol Mater Eng 2004;289:910-5.
25. Kesenci K, Fambri L, Migliaresi C, Piskin E. Preparation and properties of poly-(L-lactide)/hydroxyapatite composites. J Biomater Sci Polym Ed 2000;11(6):617-32.
26. Yan S, Yin J, Yang J, Chen X. Structural characteristics and thermal properties of plasticized poly (L-lactide)-silica nanocomposites synthesized by sol-gel method. Mater Lett 2007;61:2683-6.
27. Joshi CVS, Joshi MJ. FTIR spectroscopic, thermal and growth morphological studies of calcium hydrogen phosphate dihydrate crystals. Cryst Res Technol 2003;38:817-21.
28. Elliott JC. Structure and chemistry of the apatites and other calcium orthophosphates. New York: Elsevier Science; 1994.
29. Zhang R, Ma PX. Porous poly (L-lactic acid)/apatite composites created by biomimetic process. J Biomed Mater Res 1999;45:285-93.
30. Budyanto L, Goh YQ, Ooi CP. Fabrication of porous poly (L-lactide) (PLLA) scaffolds for tissue engineering using liquid-liquid phase separation and freeze extraction. J Mater Sci Mater Med 2009;20:105-11.
31. Tu C, Cai Q, Yang J, Wan Y, Bei J. The fabrication and characterization of poly (lactic acid) scaffolds for tissue engineering by improved solid-liquid phase separation. Polym Adv Technol 2003;14:565-73.
32. Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004;25:4749-57.
33. Song SW, Torkelson JM. Coarsening effects on the formation of microporous membranes produced via thermally induced phase separation of polystyrenecyclohexanol solutions. J Membr Sci 1995;98:209-22.
34. Simon V. Corrosion of alkali calcium phosphate bioglasses. Eur Cells Mater 2006;11(2):12.
35. Adamson AW, Gast AP. Physical chemistry of surfaces. 6th ed. New York: Wiley; 1997.
36. Ratner BD, Hoffman AS, Schoen FJ, Lemons JE. Biomaterials science, an introduction to materials in medicine. New York: Academic Press; 1996.
37. 2Oglass system. Biomaterials 2004;25:491-9. (Pubitemid 37329701)
38. 31P MAS NMR study. J Non-Cryst Solids 2000;265:221-9.
39. Oliveira JM, Correia RN, Fernandes MH. Effects of Si speciation on the in vitro bioactivity of glasses. Biomaterials 2002;23:371-9.
40. Krikorian V, Pochan DJ. Unusual crystallization behavior of organoclay reinforced poly (L-lactic acid) nanocomposites. Macromolecules 2004;37:6480-91.
41. 2 sol-gel glasses with a three-dimensionally ordered macroporous structure. Chem Mater 2001;13:1374-82.